Abstract:assessments and regulatory advice and may indicate that current levels of MPB in formulations are acceptable for young children. Background and aims An essential step in drug dosing optimalisation is prospective validation of newly proposed dosing regimens. Based on a recently published population pharmacokinetic (PK) model, a neonatal amikacin dosing regimen was developed. The aim of the current study was to prospectively validate this model-derived dosing regimen. Methods Routine amikacin therapeutic drug mo… Show more
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