O-018 New Evidence for Structural Brain Differences in Pediatric Crohnʼs Disease

Mrakotsky, Christine; Anand, Rajsavi; Watson, Christopher M.; Vu, Catherine; Matos, A. Alves de; Friel, Shelby; Rivkin, Michael J.; Snapper, Scott B.

doi:10.1097/01.mib.0000480115.50061.db

Cited by 6 publications

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“…These observations may imply a role for the CNS in chronic symptom generation and perception in IBD. Multiple factors such as systemic inflammatory response [ 130 , 131 ], fatigue [ 132 , 133 ], abdominal pain [ 134 ], psychological comorbidities [ 135 ], and medication use [ 136 , 137 , 138 ], may be linked with brain structural and functional abnormalities in IBD. Alterations in brain structure have been reported in CD patients with extraintestinal inflammation (EIM) relative to CD patients without EIM in the insula (pain processing) and the right ACC (emotion and impulse control), which may be attributed to systemic inflammation [ 131 ].…”

Section: The Effect Of Intestinal and Systemic Inflammation On Thementioning

confidence: 99%

The Gut–Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation

Moran

Thapaliya

2021

Nutrients

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Malnutrition represents a major problem in the clinical management of the inflammatory bowel disease (IBD). Presently, our understanding of the cross-link between eating behavior and intestinal inflammation is still in its infancy. Crohn’s disease patients with active disease exhibit strong hedonic desires for food and emotional eating patterns possibly to ameliorate feelings of low mood, anxiety, and depression. Impulsivity traits seen in IBD patients may predispose them to palatable food intake as an immediate reward rather than concerns for future health. The upregulation of enteroendocrine cells (EEC) peptide response to food intake has been described in ileal inflammation, which may lead to alterations in gut–brain signaling with implications for appetite and eating behavior. In summary, a complex interplay of gut peptides, psychological, cognitive factors, disease-related symptoms, and inflammatory burden may ultimately govern eating behavior in intestinal inflammation.

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Section: The Effect Of Intestinal and Systemic Inflammation On Thementioning

confidence: 99%

The Gut–Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation

Moran

Thapaliya

2021

Nutrients

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“…Individuals with intestinal disorders are often affected by cognitive and mood disorders. For example, MRI brain imaging of children (10-14 years old) with Crohn's disease showed thinning of the posterior and middle frontal gyri, poorer cognitive and verbal memory and impaired performance (Berrill et al, 2013;Gareau, 2016;Mrakotsky et al, 2016). There has also been found a correlation between colonic inflammation and deficits in the CA1 region of the hippocampus (Novotný et al, 2019).…”

Section: Gi Tract Inflammation and Cognitionmentioning

confidence: 99%

Neuro-hormonal Regulation Is a Better Indicator of Human Cognitive Abilities Than Brain Anatomy: The Need for a New Paradigm

et al. 2020

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Human intelligence has been theorized since the ancient Greeks. Plato and Aristotle incorporated theories of human intelligence into their metaphysical and cosmological theories which informed the social and medical sciences for centuries. With the advent of the 20th century, human intelligence became increasingly standardized based on Intelligence Quotients (IQ). Moreover, multiple theories of human intelligence were posited on morphological features of the human brain, focusing on cranial volume and size of the pre-frontal cortex which was suggestive of superior human cognitive abilities. This article argues that fixation with anatomical features of the brain was tended to ignore the importance of neuro-hormonal regulation which is a more appropriate indicator of human cognitive abilities. The article challenges the correlation between brain size and human cognitive abilities while offering an alternate theory of human cognitive abilities which emphasizes the roles of neurotransmitters, neurotrophins, and enteric gut microbiome (EGM) regulation.

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Microbial Technology for Neurological Disorders

Dasgupta

2023

Industrial Microbiology and Biotechnology

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O-018 New Evidence for Structural Brain Differences in Pediatric Crohnʼs Disease

Cited by 6 publications

References 0 publications

The Gut–Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation

The Gut–Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation

Neuro-hormonal Regulation Is a Better Indicator of Human Cognitive Abilities Than Brain Anatomy: The Need for a New Paradigm

Microbial Technology for Neurological Disorders

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