Nα-Acetyltransferases 10 and 15 are Required for the Correct Initiation of Endosperm Cellularization in Arabidopsis

Chen, Hongyu; Li, Shuqin; Li, Lü; Wu, Weiying; Ke, Xiaolong; Zou, Wenxuan; Jie, Zhao

doi:10.1093/pcp/pcy135

Cited by 16 publications

(13 citation statements)

References 83 publications

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“…NAA15 function has been linked to cell survival, tumor progression, and retinal development [15,16]. In addition, Naa10catalyzed N-terminal acetylation has been reported to be essential for development in many species [11,[17][18][19][20][21][22], and although NatA is not essential in S. cerevisiae, depletion of Naa10 or Naa15 has strong effects, including slow growth and decreased survival when exposed to various stresses [23,24]. NAA10 mutations were found to be associated with several human diseases characterized by severe phenotypes, including global developmental defects [11].…”

Section: Introductionmentioning

confidence: 99%

Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

Kweon

Lee

Dörfel

et al. 2021

eLife

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Amino-terminal acetylation is catalyzed by a set of N-terminal acetyltransferases (NATs). The NatA complex (including X-linked Naa10 and Naa15) is the major acetyltransferase, with 40-50% of all mammalian proteins being potential substrates. However, the overall role of amino-terminal acetylation on a whole-organism level is poorly understood, particularly in mammals. Male mice lacking Naa10 show no globally apparent in vivo amino-terminal acetylation impairment and do not exhibit complete embryonic lethality. Rather Naa10 nulls display increased neonatal lethality, and the majority of surviving undersized mutants exhibit a combination of hydrocephaly, cardiac defects, homeotic anterior transformation, piebaldism and urogenital anomalies. Naa12 is a previously unannotated Naa10-like paralogue with NAT activity that genetically compensates for Naa10. Mice deficient for Naa12 have no apparent phenotype, whereas mice deficient for Naa10 and Naa12 display embryonic lethality. The discovery of Naa12 adds to the currently known machinery involved in amino-terminal acetylation in mice.

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Section: Introductionmentioning

confidence: 99%

Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

Kweon

Lee

Dörfel

et al. 2021

eLife

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“…Whereas mos4 reverses the dwarf phenotype of snc1 , this double-mutant phenotype is itself reversed with concurrent partial loss-of-function of the n-acetyltransferase EMBRYO DEFECTIVE 2573 (EMB2573; a homolog of gene candidate Potri.001G177801), restoring the dwarf morphology. Knockout of EMB2573 also confers a wide range of defects including in embryo differentiation, notably in the shoot apical meristem (SAM), as indicated by abolished expression of the SAM marker SHOOT MERISTEMLESS (Chen et al ., 2018). MOS4 and EMB2573 are believed to regulate degradation of SNC1 in addition to other genes involved in related SA-signaling roles (Xu et al ., 2015).…”

Section: Discussionmentioning

confidence: 99%

GWAS identifies candidate regulators of in planta regeneration in Populus trichocarpa

Nagle

Yuan

Kaur

et al. 2022

Preprint

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Plant regeneration is an element of natural and horticultural plant propagation, and a key step in the production of transgenic plants. However, regeneration capacity varies widely among genotypes and species, the molecular basis of which is largely unknown. To shed light on the causes of variation in natural regeneration capacity, we undertook a GWAS of shoot regeneration from dormant cut stems in Populus trichocarpa. Using estimates of callus and shoot regeneration provided by a novel computer vision system, and using a variety of GWAS pipelines and statistical approaches, our analyses revealed over 200 candidate genes. The candidates each explained small fractions of the total genetic variance and many appeared to be members of genetic regulatory networks, showing regeneration to be a highly polygenic trait. The top candidates included regulators of cell adhesion, stress signaling, and hormone signaling pathways, as well as other diverse functions. These candidates provide new insights into the biological complexity of plant regeneration, and may serve as new reagents for improving regeneration and transformation of recalcitrant genotypes and species.

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“…This modification is dynamically regulated by acyltransferases and deacetylases, although non-enzymatic acetylation by acetyl-CoA and NAD has also been reported [130]. An N-terminal acetyltransferase (AtNatA) has been reported in Arabidopsis , containing catalytic (NAA10) and auxiliary (NAA15) subunits, which is involved in embryogenesis, endosperm development, plant immunity and responses to drought [131]. Nevertheless, our understanding of the physiological effects of acetylation, as well as the overall interplay and regulation of the acetylome itself in plants, remains elusive [132].…”

Section: Post-translational Modification Of Peroxisomal Proteinsmentioning

confidence: 99%

Multilevel Regulation of Peroxisomal Proteome by Post-Translational Modifications

Sandalio

Gotor

Romero

et al. 2019

IJMS

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Peroxisomes, which are ubiquitous organelles in all eukaryotes, are highly dynamic organelles that are essential for development and stress responses. Plant peroxisomes are involved in major metabolic pathways, such as fatty acid β-oxidation, photorespiration, ureide and polyamine metabolism, in the biosynthesis of jasmonic, indolacetic, and salicylic acid hormones, as well as in signaling molecules such as reactive oxygen and nitrogen species (ROS/RNS). Peroxisomes are involved in the perception of environmental changes, which is a complex process involving the regulation of gene expression and protein functionality by protein post-translational modifications (PTMs). Although there has been a growing interest in individual PTMs in peroxisomes over the last ten years, their role and cross-talk in the whole peroxisomal proteome remain unclear. This review provides up-to-date information on the function and crosstalk of the main peroxisomal PTMs. Analysis of whole peroxisomal proteomes shows that a very large number of peroxisomal proteins are targeted by multiple PTMs, which affect redox balance, photorespiration, the glyoxylate cycle, and lipid metabolism. This multilevel PTM regulation could boost the plasticity of peroxisomes and their capacity to regulate metabolism in response to environmental changes.

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Nα-Acetyltransferases 10 and 15 are Required for the Correct Initiation of Endosperm Cellularization in Arabidopsis

Cited by 16 publications

References 83 publications

Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

GWAS identifies candidate regulators of in planta regeneration in Populus trichocarpa

Multilevel Regulation of Peroxisomal Proteome by Post-Translational Modifications

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