“…However, GluN2A and GluN2B nonionotropic LTD were not directly compared. NMDARs containing GluN2A (Hu et al, 2016; Li et al, 2016; Vissel, Krupp, Heinemann, & Westbrook, 2001) or GluN2B (Bowers et al, 2020; Ferreira et al, 2017; Kessels, Nabavi, & Malinow, 2013; Tamburri, Dudilot, Licea, Bourgeois, & Boehm, 2013) produce nonionotropic signals, but variations in the magnitude, time‐course, or molecular components of evoked nonionotropic LTD have not been compared across GluN2 subunits. Third, direct studies of relationships between NMDAR nonionotropic signaling and cognitive abilities are required.…”