Nystatin (Mycostatin) in the Treatment of Monilial and Nonmonilial Vaginitis

Activity of liposomal nystatin against disseminated Aspergillus fumigatus infection in neutropenic mice

“…In addition to its antifungal activity in vitro and in animals, nystatin has been shown to be effective against a variety of fungi in humans, including Candida (32), Aspergillus (47), Histoplasma (36), and Coccidioides (32). Nystatin has demonstrated antifungal activity in humans following administration by different routes, including the oral (8,39), pleural (28,34), inhalation (14,40,43,50), and topical (25,35,47) routes. Nystatin has been used since the 1950s mainly for the treatment of cutaneous, vaginal, and oral candidiases (3).…”

Experiences in a Vaginitis Clinic

“…We have not experienced the higher inci¬ dence of monilial infections in recent years that has been reported by others. 8 Monilial vulvovaginitis is manifested clinically by a scant, thin, irritating discharge with white flakes. The vagina and cervix are inflamed, with patches of white ("cream-cheese" vaginitis, "cottagecheese" vaginitis).…”

‘Fungilin’ Pessaries in the Treatment of Vaginal Candidosis in General Practice

“…At one time therapy consisted of the topical application of organic dyes, the most popular being an aqueous solution of gentian violet. The action of gentian violet, however, is somewhat unreliable (Pace & Schantz 1956) and if applied too frequently or in a strength greater than 1 per cent may cause chemical irritation (Gardner 1964). From the patients' points of view it is difficult to apply and is unpopular because of its staining properties.…”