Nymphasterol, a new steroid from Nymphaea stellata

Verma, Amita; Ahmed, Bahar; Upadhyay, Rucha; Soni, Neetu

doi:10.1007/s00044-011-9591-7

Cited by 8 publications

(6 citation statements)

References 3 publications

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“…Protein, pentosan, mucilage and tannins are reported in the seeds [15] . But no extensive chemical investigation has been done so far in the seeds except for a new steroid which was isolated from the methanolic fraction recently and was designated as nymphasterol [16] .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical analysis and In vitro antioxidant acitivity of hydroalcoholic seed extract of Nymphaea nouchali Burm. f.

Parimala

Shoba

2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Introductionmentioning

confidence: 99%

Phytochemical analysis and In vitro antioxidant acitivity of hydroalcoholic seed extract of Nymphaea nouchali Burm. f.

Parimala

Shoba

2013

Asian Pacific Journal of Tropical Biomedicine

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“…Compounds 1, 2, 4 and 6 were isolated and identified as components in N. pubescens petals for the first time. Previous studies reported that 4 was found in the N. stellata flowers [37], 3 and 5 were found in the N. pubescens petals [18,38,39], while 6 was found in the N. stellata flowers [40] and the N. Alba flowers [41] and leaves [42]. Compound 4 has been previously isolated from Rhamnus nakaharai Hayata (Rhamnaceae) and reported to inhibit PDE5 enzymes isolated from the lungs and hearts of male guinea pigs with an IC 50 value of 86.9 µM [43], 3 and 5 have been previously isolated from Anaxagorea luzonensis and reported to inhibit PDE5 enzymes isolated from the mice lungs [14], while 1, 2, and 6 has not previously been reported for their effects on PDE5.…”

Section: Discussionmentioning

confidence: 87%

Phosphodiesterase 5 and Arginase Inhibitory Activities of the Extracts from Some Members of Nelumbonaceae and Nymphaeaceae Families

et al. 2023

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The objectives of this study were (1) to investigate the effect of extracts from some plants in the families Nelumbonaceae and Nymphaeaceae on phosphodiesterase 5 (PDE5) and arginase, which have been used in erectile dysfunction treatment, and (2) to isolate and identify the compounds responsible for such activities. The characterization and quantitative analysis of flavonoid constituents in the active extracts were performed by HPLC. Thirty-seven ethanolic extracts from different parts of plants in the genus Nymphaea and Victoria of Nymphaeaceae and genus Nelumbo of Nelumbonaceae were screened for PDE5 and arginase inhibitory activities. The ethanolic extracts of the receptacles and pollens of Nelumbo nucifera Gaertn., petals of Nymphaea cyanea Roxb. ex G.Don, Nymphaea stellata Willd., and Victoria amazonica (Poepp.) Sowerby and the petals and receptacles of Nymphaea pubescens Willd. showed IC50 values on PDE5 of less than 25 μg/mL while none of the extracts showed effects on arginase. The most active extract, N. pubescens petal extract, was fractionated to isolate and identify the PDE5 inhibitors. The results showed that six flavonoid constituents including quercetin 3’-O-β-xylopyranoside (1), quercetin 3-methyl ether 3’-O-β-xylopyranoside (2), quercetin (3), 3-O-methylquercetin (4), kaempferol (5) and 3-O-methylkaempferol (6) inhibited PDE5 with IC50 values at the micromolar level.

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“…β-Sitosterol has been reported from the 5 BioMed Research International alcoholic flower extract from Nymphaea alba [42], while nymphyol has been reported from Nymphae astellate [18]. Nymphasterol has been reported from the seeds of Nymphaea stellata [43], and β-sitosterol and β-sitosterol-3-o-β-D-glucopyranoside have been reported from the methanolic extract of whole plants of Nymphaea pulchella and Nymphaea gracilli [44]. Nymphaeoside A and Icariside E4 have been reported from the ethanolic extract of the leaves of Nymphaea odorata [13].…”

Section: Glycation and Its Role In Type 2 Diabetes Mellitusmentioning

confidence: 99%

Role of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species

Ishrat

Khan

Patel

et al. 2021

BioMed Research International

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The dysregulation of glucose metabolism that includes the modification of biomolecules with the help of glycation reaction results in the formation of advanced glycation end products (AGEs). The formation of AGEs may activate receptors for advanced glycation end products which induce intracellular signaling, ultimately enhancing oxidative stress, a well-known contributor to type 2 diabetes mellitus. In addition, AGEs are possible therapeutic targets for the treatment of type 2 diabetes mellitus and its complications. This review article highlights the antioxidant, anti-inflammatory, and antidiabetic properties of the Nymphaea species, and the screening of such aquatic plants for antiglycation activity may provide a safer alternative to the adverse effects related to glucotoxicity. Since oxidation and glycation are relatively similar to each other, therefore, there is a possibility that the Nymphaea species may also have antiglycating properties because of its powerful antioxidant properties. Herbal products and their derivatives are the preeminent resources showing prominent medicinal properties for most of the chronic diseases including type 2 diabetes mellitus. Among these, the Nymphaea species has also shown elevated activity in scavenging free radicals. This species has a load of phytochemical constituents which shows various therapeutic and nutritional value including anti-inflammatory and antioxidant profiles. To the best of our knowledge, this is the first article highlighting the possibility of an antiglycation value of the Nymphaea species by inhibiting AGEs in mediation of type 2 diabetes mellitus. We hope that in the next few years, the clinical and therapeutic potential may be explored and highlight a better perspective on the Nymphaea species in the inhibition of AGEs and its associated diseases such as type 2 diabetes mellitus.

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Nymphasterol, a new steroid from Nymphaea stellata

Cited by 8 publications

References 3 publications

Phytochemical analysis and In vitro antioxidant acitivity of hydroalcoholic seed extract of Nymphaea nouchali Burm. f.

Phytochemical analysis and In vitro antioxidant acitivity of hydroalcoholic seed extract of Nymphaea nouchali Burm. f.

Phosphodiesterase 5 and Arginase Inhibitory Activities of the Extracts from Some Members of Nelumbonaceae and Nymphaeaceae Families

Role of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species

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