Nye markører for påvisning av alkoholbruk

Aakerøy, Rachel; Skråstad, Ragnhild Bergene; Helland, Arne; Hilberg, Thor; Aamo, Trond; Dyrkorn, Roar; Spigset, Olav

doi:10.4045/tidsskr.16.0056

Cited by 7 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PEth concentrations between 0.03 μmol/L and 0.30 μmol/L are interpreted as being consistent with moderate or significant alcohol consumption, whereas concentrations above 0.30 μmol/L are considered to be indicative of heavy alcohol consumption [33]. It is consensus that PEth concentrations reflect alcohol consumption in the two to four preceding weeks [34]. Continuous data were compared by independent samples t-test or Mann-Whitney U-test, as appropriate.…”

Section: Analysis Of Pethmentioning

confidence: 99%

Identification of unhealthy alcohol use by self-report and phosphatidylethanol (PEth) blood concentrations in an acute psychiatric department

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background The use of standard screening methods could improve the detection rate of unhealthy alcohol use in patients admitted to psychiatric acute and emergency departments. The aim of the present study was to investigate the ability of the alcohol biomarker phosphatidylethanol (PEth) to identify patients with high levels of alcohol consumption prior to admission. Methods The data were prospectively collected at admittance to an acute psychiatric department in the period January 2016 to June 2017. A blood sample for the analysis of PEth was available from 177 patients. We compared the PEth concentrations with the Alcohol Use Disorders Identification Test (AUDIT) scores during the hospital stay, and psychiatric diagnoses at discharge. Results A total of 45.8% of the patients had a PEth concentration ≥ 0.03 μmol/L, indicating significant alcohol consumption. AUDIT scores consistent with unhealthy alcohol use were present in 51.7%. There was a significant positive correlation between PEth concentrations and AUDIT scores (r = 0.631, p < 0.001). PEth was above the detection limit of 0.03 μmol/L in 19% of those reporting an average daily intake of zero alcohol units per day during the last week before admission. PEth concentrations were significantly higher among those with an alcohol diagnosis than among those without such a diagnosis (0.82 μmol/L vs. 0.09 μmol/L, p = 0.001). Conclusion PEth provides supplementary information on recent alcohol consumption in a psychiatric population and would be particularly helpful in patients unable or unwilling to give such information at admission.

show abstract

Section: Analysis Of Pethmentioning

confidence: 99%

Identification of unhealthy alcohol use by self-report and phosphatidylethanol (PEth) blood concentrations in an acute psychiatric department

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Some guidelines for the interpretation of a given PEth concentration are available, and various threshold concentrations for PEth distinguishing between moderate and excessive alcohol consumption have been suggested ( Ulwelling and Smith, 2018 ; Luginbühl et al., 2022 ). A PEth concentration of 20 ng/ml (0.028 μmol/l) or 0.030 μmol/l (21.4 ng/ml) has been proposed as an arbitrary threshold for alcohol ingestion, and a PEth concentration of 200 ng/ml (0.28 μmol/l) or 0.30 μmol/l (214 ng/ml) as a threshold for ‘heavy consumption’ ( Helander and Hansson, 2013 ; Aakeroy et al., 2016 ; Ulwelling and Smith, 2018 ). These cut-off concentrations have been based on studies with distinct limitations, such as largely being performed in selected high-consumer populations and/or having a limited sample size ( Kechagias et al., 2015 ; Afshar et al., 2017 ; Schrock et al., 2017 ; Moore et al., 2018 ; Wang et al., 2018 ; Helander et al., 2019 ; Kabashi et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Quantifying Alcohol Consumption in the General Population by Analysing Phosphatidylethanol Concentrations in Whole Blood: Results from 24,574 Subjects Included in the HUNT4 Study

Skråstad

Aamo

Andreassen

et al. 2023

Alcohol and Alcoholism

View full text Add to dashboard Cite

Aims To evaluate the association between self-reported alcohol consumption and phosphatidylethanol (PEth) concentrations in blood in a large general population study, and discuss optimal cut-off PEth concentrations for defined levels of alcohol consumption. Methods Population based, longitudinal cohort study including 24,574 adults from The Trøndelag Health Study 4 (HUNT4) conducted in Trøndelag County, Norway. Data included PEth concentration, self-reported alcohol consumption and CAGE score. Results PEth levels in whole blood increased with the number of alcohol units consumed, the frequency of alcohol consumption, the frequency of binge drinking and the CAGE score (lifetime, i.e. ‘have you ever’). The cut-off concentrations with highest combined sensitivity and specificity were 0.057 μmol/l (40 ng/ml) for identification of those consuming >1 alcohol unit per day (sensitivity 86%, specificity 76%), 0.087 μmol/l (61 ng/ml) for consuming >2 units per day (sensitivity 87%, specificity 81%) and 0.122 μmol/l (86 ng/ml) for consuming >3 alcohol units per day (sensitivity 80%, specificity 86%). By defining a CAGE score ≥ 2 as potentially harmful consumption, a cut-off of 0.100 μmol/l (70 ng/ml) identified 52% of all those subjects. Conclusions Cut-off limits of PEth concentrations should take into account the indication for sampling. Using cut-offs for the PEth concentrations of about 0.05 μmol/l (35 ng/ml) and 0.08 μmol/l (56 ng/ml) would identify about 90% of the subjects consuming more than 1 and 2 alcohol units per day, respectively. Concentrations above these cut-offs should lead to a more detailed interview related to alcohol use.

show abstract

“…Nalesso et al identified 17 different PEths in blood from alcohol‐dependent subjects, whereas only PEth 16:0/18:1 and PEth 16:0/18:2 were found in blood from social drinkers. The average half‐life of PEth is approximately 3‐5 days for heavy drinkers and 10‐12 days for persons with no or low alcohol consumption . A blood concentration of PEth ≥211 ng/mL (300 nmol/L) indicates alcohol abuse, whereas a PEth concentrations ≤21 ng/mL (≤30 nmol/L) indicate low alcohol consumption …”

Section: Introductionmentioning

confidence: 99%

“…The average half‐life of PEth is approximately 3‐5 days for heavy drinkers and 10‐12 days for persons with no or low alcohol consumption . A blood concentration of PEth ≥211 ng/mL (300 nmol/L) indicates alcohol abuse, whereas a PEth concentrations ≤21 ng/mL (≤30 nmol/L) indicate low alcohol consumption …”

Section: Introductionmentioning

confidence: 99%

Determination of phosphatidylethanol 16:0/18:1 in whole blood by 96‐well supported liquid extraction and UHPLC‐MS/MS

Berg

Eliassen

Jørgenrud

et al. 2018

Clinical Laboratory Analysis

View full text Add to dashboard Cite

For the first time, 96-well SLE was used for preparation of a PEth homologue in biological samples. A mixture of tert-butyl methyl ether and 2-propanol (5:1, v:v) was chosen as organic eluent based on an evaluation of extraction recovery, purity of extracts, and evaporation time. The developed UHPLC-MS/MS method can be used for high throughput analyses and sensitive determinations of PEth 16:0/18:1 in whole blood.

show abstract

Nye markører for påvisning av alkoholbruk

Cited by 7 publications

References 14 publications

Identification of unhealthy alcohol use by self-report and phosphatidylethanol (PEth) blood concentrations in an acute psychiatric department

Identification of unhealthy alcohol use by self-report and phosphatidylethanol (PEth) blood concentrations in an acute psychiatric department

Quantifying Alcohol Consumption in the General Population by Analysing Phosphatidylethanol Concentrations in Whole Blood: Results from 24,574 Subjects Included in the HUNT4 Study

Determination of phosphatidylethanol 16:0/18:1 in whole blood by 96‐well supported liquid extraction and UHPLC‐MS/MS

Contact Info

Product

Resources

About