Nycthemeral variations of cholecystokinin action on intestinal motility in rats: effects of melatonin and S 20928, a melatonin receptor antagonist

Merle, Audrey; Faucheron, Jean‐Luc; Delagrange, P.; Renard, Pierre; Roche, Maurice; Pellissier, Sonia

doi:10.1054/npep.2000.0835

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…This effect of melatonin on intestinal motility could be direct or via modulation of factors, such as gut hormones. In another study using the same protocol, we verified this hypothesis with cholecystokinin (CCK) (37). The excitomotor effect of exogenous CCK (5 µg/kg i.v) is significantly longer (+60%) when this neuropeptide is injected during the light phase than during the dark phase.…”

Section: Animal Modelsmentioning

confidence: 56%

Therapeutic Perspectives for Melatonin Agonists and Antagonists

Delagrange¹,

Atkinson²,

Boutin³

et al. 2003

J Neuroendocrinology

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Melatonin is a neurohormone synthesized in the pineal gland during the dark period in all species, including humans. The diversity and differences in melatonin receptor distribution in the brain and extracerebral organs suggest multiple functional roles for melatonin. Administration of melatonin agonists reduces neophobia and treatment with a melatonin antagonist during the dark period reverses the anxiolytic-like effect of endogenous melatonin. Chronic treatment with agonists prevents various perturbations induced by chronic mild stress. Melatonin in vivo directly constricts cerebral arterioles in rats and decreases the lower limit of cerebral blood flow autoregulation, suggesting that melatonin may diminish the risk of hypoperfusion-induced cerebral ischemia. At the extracerebral level, melatonin regulates intestinal motility in rats. The intestinal postprandial motor response is shorter in the dark phase than in the light phase and this reduction is reversed in animals pretreated with a melatonin antagonist. Moreover, melatonin reduces the duration of cholecystokinin excitomotor effect. Endogenous melatonin may modulate intestinal motility to coordinate intestinal functions such as digestion and transit and control the metabolism of the animal. An adipocyte melatonin binding site may also participate in this control. Melatonin is involved in a wide range of physiological functions. The question remains as to whether evolution, adaptation and diurnal life have modified the physiological role of melatonin in humans. Moreover, the functional role of each of the receptor subtypes has to be characterized to design selective ligands to treat specific diseases.

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Section: Animal Modelsmentioning

confidence: 56%

Therapeutic Perspectives for Melatonin Agonists and Antagonists

Delagrange¹,

Atkinson²,

Boutin³

et al. 2003

J Neuroendocrinology

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“…These findings suggest that the mechanism of CCK action on duodenal motility is composed and may exhibit even the adaptive features. However, it seems to be amply confirmed that the effect of CCK on duodenal motility in man, dog, rabbit, rat and sheep is excitatory (Gutiérrez et al, 1974;Heppell et al, 1982;Elbrønd et al, 1994;Merle et al, 2000;Romański, 2004). Thus, the stimulatory effect of a moderate dose of CCK on duodenal motility seems to be primary (Mizumoto et al, 1992), and this conclusion can be inferred also from the present study.…”

Section: Discussionmentioning

confidence: 99%

Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep

Romanski¹

2010

CZECH J ANIM SCI

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Cholecystokinin (CCK) affects the intestinal motility but in ruminants the question has not been entirely explored. The aim of this study was to examine the precise effects of CCK-octapeptide (CCK-OP) and its amphibian analogue, cerulein, on duodenal motor activity in unfasted rams in the course of chronic experiments. Five rams underwent the implantation of a strain gauge force transducer to the duodenal wall, and -additionally -the bipolar platinum electrodes to the duodenal bulb, distal duodenum, near the strain gauge force transducer, and proximal jejunum. During continuous motor recordings, 0.15M NaCl or CCK peptides were administrated intravenously. Injections of CCK-OP at doses of 20 (over 30 s), 200 (over 30 or 60 s), and 2 000 (over 30, 60, or 120 s) ng/kg of body weight and injections of cerulein at doses of 1, 10, or 100 ng/kg (given over the same periods) were each administered in the course of duodenal phase 1, 2a, or 2b of the migrating motor complex (MMC), i.e. 5 min after the onset of each phase. Injections of the smallest doses of CCK peptides exerted a slight and mostly insignificant effect on the duodenal areas under contraction (AUC). In the duodenum, the moderate doses of the hormones evoked short stimulatory effects followed by longer inhibitory biphasic effects on AUC. These effects were inversely related to the duration of the hormone injection. It is concluded that CCK evokes stimulatory and inhibitory (biphasic) physiological effects on duodenal motility in sheep.

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“…Once released, melatonin may exert a wide range of functions in the GIT by activating its receptors. However, while melatonin's role has been convincingly established in the regulation of duodenal bicarbonate secretion [15–18] and the small intestine motility [11, 12], its function in the distal intestinal segments remains largely unknown. Experiments of Chan et al [14] on colonic adenocarcinoma derived cell line T84 showed that high concentration of melatonin may influence ion transport but no data on the native tissue has so far been available.…”

Section: Discussionmentioning

confidence: 99%

“…Although the estimated amount of melatonin in the GIT surpasses the amount of melatonin in pineal gland by more than 400 times [6], the role of melatonin in this ‘ever‐dark place’ has only recently started to be uncovered. The wide spectrum of biological actions of melatonin in the gut comprises antioxidant effects [7], regulation of enterocyte mitotic activity [8], interaction with immune system [9, 10], modulation of intestinal motility [11–13] and epithelial ion transport regulation [14–18].…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous expression of melatonin receptor MT1 mRNA in the rat intestine under control and fasting conditions

Soták

Mrnka

Pácha

2006

Journal of Pineal Research

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Melatonin is found in mammalian central nervous system and various peripheral tissues including gastrointestinal tract (GIT) where it participates in the regulation of intestinal motility, blood flow, immunomodulation, ion transport, cell proliferation and scavenging of free radicals. Some of these effects are achieved via melatonin binding to specific receptors, MT1 and MT2. As no thorough study on the expression of these receptors in the GIT has yet been done, the aim of this study was to determine the MT1 mRNA expression in the rat intestine under both control and fasting conditions. Our results suggest that MT1 mRNA is present in epithelial as well as subepithelial layer, with higher expression in the latter in all intestinal segments studied. The highest signal of the MT1 transcript along the rostro-caudal intestinal axis was found both in epithelial and subepithelial layers of the duodenum. Nevertheless, duodenal MT1 mRNA expression did not reach the level found in pituitary gland. In a 12:12-hr light:dark cycle a MT1 receptor expression in the subepithelial layer of rat distal colon did not manifest a significant diurnal rhythm. Short-term fasting increased the expression of MT1 transcript in the subepithelial layer of both the small and large intestine. During long-term fasting the increase persisted only in distal colon while a return to control levels was observed in small intestinal segments. In conclusion we demonstrated heterogeneous expression of MT1 receptor in the rat intestine and showed that its expression is up-regulated by nutritional deprivation.

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Nycthemeral variations of cholecystokinin action on intestinal motility in rats: effects of melatonin and S 20928, a melatonin receptor antagonist

Cited by 9 publications

References 19 publications

Therapeutic Perspectives for Melatonin Agonists and Antagonists

Therapeutic Perspectives for Melatonin Agonists and Antagonists

Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep

Heterogeneous expression of melatonin receptor MT1 mRNA in the rat intestine under control and fasting conditions

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