NY‐ESO‐1 antigen: A promising frontier in cancer immunotherapy
Alaa Alsalloum,
Julia A. Shevchenko,
Sergey Sennikov
Abstract:Significant strides have been made in identifying tumour‐associated antigens over the past decade, revealing unique epitopes crucial for targeted cancer therapy. Among these, the New York esophageal squamous cell carcinoma (NY‐ESO‐1) protein, a cancer/testis antigen, stands out. This protein is presented on the cell surface by major histocompatibility complex class I molecules and exhibits restricted expression in germline cells and various cancers, marking it as an immune‐privileged site. Remarkably, NY‐ESO‐1… Show more
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