Nutritionally Variant Streptococci Bacteremia in Cancer Patients:  a Retrospective Study, 1999-2014

Yacoub, Abraham Tareq; Krishnan, Jayasree; Acevedo, Ileana; Halliday, Joseph; Greene, John N.

doi:10.4084/mjhid.2015.030

Cited by 11 publications

(9 citation statements)

References 22 publications

(29 reference statements)

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“…A relationship between periodontal inflammation and bacteremia has been reported in an observational study showing that patients with gingivitis/periodontitis more often developed bacteremia owing to coagulase-negative staphylococci and oral viridans streptococci during neutropenia than did those with a healthy periodontium ( p = 0.047) [8]. A retrospective study showed that 61.5% of cancer patients with NVS bacteremia had mucositis or gingivitis [9]. In non-neutropenic patients, a previous report showed that the generalized presence of gingival bleeding after tooth brushing (which is a sign of gingivitis or periodontitis) was associated with an almost eightfold increase in the risk of bacteremia [10].…”

Section: Discussionmentioning

confidence: 92%

Infective endocarditis and Sjögren’s syndrome diagnosed simultaneously

Morita

Hirai

Suzuki

et al. 2017

IDCases

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Poor dentition and/or dental infection due to insufficient oral care are presumed to be risk factors for infective endocarditis (IE). We present a case of endocarditis caused by Granulicatella adiacens and Sjögren’s syndrome (SS) with oral complications diagnosed simultaneously.A 67-year-old woman was admitted to our hospital with fever, general fatigue, arthralgia, and back pain. She was diagnosed with primary SS according to the criteria of the American-European Consensus Group. Transthoracic echocardiography carried out to examine her persistent fever revealed vegetation formation (14 × 5 mm) on the aortic valve and her blood cultures were positive for G. adiacens. According to modified Duke’s criteria, she was also diagnosed with IE. She underwent aortic valve replacement and was administered ampicillin with gentamicin for 6 weeks following surgery.G. adiacens, which is formerly known as one of the nutritionally variant streptococci, is found as part of the normal microbiota of the oral cavity. The patient had chronic periodontitis associated with SS that likely predisposed to G. adiacens bacteremia and subsequent seeding of the aortic valve. Patients with SS may be at risk of IE because of the increased risk of bacteremia from oral complications such as dental caries or periodontal disease.An association between SS and IE has not yet been reported. Our case indicates that SS may be the underlying pathology in patients with IE due to an oral bacterium.

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Section: Discussionmentioning

confidence: 92%

Infective endocarditis and Sjögren’s syndrome diagnosed simultaneously

Morita

Hirai

Suzuki

et al. 2017

IDCases

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“…Several “indicator” genera of the highest IL‐1β quartile were low‐abundant phylotypes, previously documented in diverse opportunistic infections and immune subversion. Abiotrophia , a common oral genus earlier grouped under “nutritionally variant Streptococci ” is implicated in bacteremia and invasive infections (Senn et al., ; Yacoub et al., ). In the oral niche, supragingival Abiotrophia associated with leukemic status and indicated dysbiosis related to perturbed immune status (Wang et al, , ).…”

Section: Discussionmentioning

confidence: 99%

“…Abiotrophia, a common oral genus earlier grouped under "nutritionally variant Streptococci" is implicated in bacteremia and invasive infections (Senn et al, 2006;Yacoub et al, 2015). In the oral niche, supragingival…”

Section: Otu-representingmentioning

confidence: 99%

Salivary microbiome of an urban Indian cohort and patterns linked to subclinical inflammation

et al. 2017

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“…produces β-and α-galactosidase. The genus contains one species of Abiotrophia defectiva, which can cause bacteraemia, keratitis [38], oral mucositis and gingivitis [58], urinary tract infection [17] and infective endocarditis [15,17]. More commonly, Abiotrophia spp.…”

Section: Streptococci With Special Nutritional Requirementsmentioning

confidence: 99%

New Species Of Bacteria In Human Infections

Sękowska

Gospodarek‐Komkowska

2019

Postępy Mikrobiologii - Advancements of Microbiology

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In the last few years, there have been works in literature describing clinical cases of infections with bacteria previously considered to be non-pathogenic. So far, these bacteria have been commonly isolated from the natural environment: water, soil, plants, and isolation from a sample of clinical material has often been considered an impurity. Therefore, the aim of the paper was to draw attention to newly emerging bacterial species, their characteristics, biochemical properties, virulence factors and predisposition to selected forms of infection in groups of patients with specific risk factors. The impact on the more frequent isolation of species of bacteria previously considered to be non-pathogenic has several aspects: reliable diagnostic methods, including correct identification of the species, enabling the differentiation of closely related bacteria, the growing group of immune-compromised patients and with infectious risk factors (such as older age, diabetes, tumours, organ transplantation), more susceptible to infection, also with less pathogenic microorganisms. Greater adaptability of bacteria to new environmental conditions, including the human body, are also worth mentioning. The pathogenic effect of these bacteria, mainly related to the production of biofilms and factors conditioning adhesion to host cells or biomaterials, facilitating colonization and subsequent infection, is also important. The progress in medicine that has taken place in recent years has positively influenced the life expectancy of patients with certain diseases and in many situations, it contributed to an improvement in its quality. Unfortunately, it also made it possible to cause infection with bacteria that were previously considered to be low or non-pathogenic.

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Nutritionally Variant Streptococci Bacteremia in Cancer Patients: a Retrospective Study, 1999-2014

Cited by 11 publications

References 22 publications

Infective endocarditis and Sjögren’s syndrome diagnosed simultaneously

Infective endocarditis and Sjögren’s syndrome diagnosed simultaneously

Salivary microbiome of an urban Indian cohort and patterns linked to subclinical inflammation

New Species Of Bacteria In Human Infections

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