Nutritionally Mediated Oxidative Stress and Inflammation

Muñoz, Alexandra; Costa, Max

doi:10.1155/2013/610950

Cited by 153 publications

(122 citation statements)

References 86 publications

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“…It was suggested that GPR84 acts as a proinflammatory receptor linking fatty acid metabolism to immunological res ponses (34)(35)(36). Other fatty acids such as arachidonic acid and saturated fatty acids have been demonstrated to increase proinflammatory IL-8 along with numerous other inflammatory factors, including IL-6, TNF-α, IL-1β and CXCL1 (37). Agonists of GPR84 were shown to amplify IL-8 production by PMNs, and GPR84 agonists work as chemo-attractants to both PMNs and macrophages (38).…”

Section: Factor Analysis Identified Cinc1-3 Mip-1/3` Mig Rantes Anmentioning

confidence: 99%

GPR84 and TREM-1 Signaling Contribute to the Pathogenesis of Reflux Esophagitis

Abdel-Aziz

Schneider

Neuhuber

et al. 2015

Mol Med

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Gastro-esophageal reflux disease (GERD) is one of the most common disorders in gastroenterology. Patients present with or without increased acid exposure indicating a nonuniform etiology. Thus, the common treatment with proton pump inhibitors (PPIs) fails to control symptoms in up to 40% of patients. To further elucidate the pathophysiology of the condition and explore new treatment targets, transcriptomics, proteomics and histological methods were applied to a surgically induced subchronic reflux esophagitis model in Wistar rats after treatment with either omeprazole (PPI) or STW5, a herbal preparation shown to ameliorate esophagitis without affecting refluxate pH. The normal human esophageal squamous cell line HET-1A and human endoscopic biopsies were used to confirm our findings to the G-protein-coupled receptor (GPR) 84 in human tissue. Both treatments reduced reflux-induced macroscopic and microscopic lesions of the esophagi as well as known proinflammatory cytokines. Proteomic and transcriptomic analyses identified CINC1-3, MIP-1/3α, MIG, RANTES and interleukin (IL)-1β as prominent mediators in GERD. Most regulated cyto-/chemokines are linked to the TREM-1 signaling pathway. The fatty acid receptor GPR84 was upregulated in esophagitis but significantly decreased in treated groups, a finding supported by Western blot and immunohistochemistry in both rat tissue and HET-1A cells. GPR84 was also found to be significantly upregulated in patients with grade B reflux esophagitis. The expression of GPR84 in esophageal tissue and its potential involvement in GERD are reported for the first time. IL-8 (CINC1-3) and the TREM-1 signaling pathway are proposed, besides GPR84, to play an important role in the pathogenesis of GERD.

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Section: Factor Analysis Identified Cinc1-3 Mip-1/3` Mig Rantes Anmentioning

confidence: 99%

GPR84 and TREM-1 Signaling Contribute to the Pathogenesis of Reflux Esophagitis

Abdel-Aziz

Schneider

Neuhuber

et al. 2015

Mol Med

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“…Th us, the fi ndings of a recent study (Gregson, Drust, Atkinson, & Salvo, 2010) indicate that match-to-match variability in performance characteristics of elite soccer players is high. Moreover, many factors within the body can infl uence muscle damage, such as infl ammation (Stoner et al, 2013), nutrition (Muñoz & Costa, 2013), intake of supplements (Goldfarb, 1999;Goldfarb, Garten, Cho, Chee, & Chambers, 2011). A signifi cant increase in muscle damage markers (Andersson, Ekblom, & Krustrup, 2008;Ascensão et al, 2008;Ispirlidis et al, 2008;Magalhães et al, 2010) has been described immediately aft er "friendly" soccer matches and throughout the post-match recovery.…”

Section: Introductionmentioning

confidence: 99%

Post-Match Changes in Muscle Damage Markers among U-21 Soccer Players

Trajković¹,

Sporis²,

Vlahović³

et al. 2018

Monten. J. Sports Sci. Med.

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Th is study aimed to investigate the eff ect of offi cial soccer matches on selected markers of muscle damage in U-21 soccer players. A group of 19 trained, healthy male soccer players from the junior category took part in this study. Blood samples were assessed pre-match and immediately aft er a match in response to a competitive (2×45 min) soccer match. Analysis was performed for muscle damage and infl ammatory markers. Signifi cant diff erences between two measures (before and aft er soccer match) exist in Aspartate-aminotransferase (AST), Lactate dehydrogenase (LDH), and Myoglobin. Plasma K + signifi cantly decreased aft er the match (p<0.05), whereas plasma Na + decreased slightly. Th is study showed that most selected markers of muscle damage were infl uenced by a soccer match. However, results remain inconsistent because of the infl uence of the type, duration, and intensity of exercise. Moreover, some markers show great variability among individuals.

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“…The current results showed that by prolonging consumption of TPC 35 oil, the level of 8-isoprostane increased. Oxidative stress is proposed as a stimulatory factor in increasing inflammatory mediators (30). Accordingly, at the end of the study, IL-1β in the TPC 35 group was higher than the other groups.…”

Section: Discussionmentioning

confidence: 83%

The Effects of Heated Oils Used in Fast Food Restaurants on Metabolic, Inflammatory and Oxidative Stress Markers, Blood Pressure, and Liver Histology in Sprague-Dawley Rats

Ghobadi

Akhlaghi

Mokhtari

et al. 2018

Iran Red Crescent Med J

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Background: Long and repeated heating causes multiple physical and chemical changes in oil, which may result in serious biological damages upon consumption. Objectives: This study investigated the effects of heated oils used in fast food restaurants on metabolic, inflammatory, and oxidative stress markers in rats. Methods: The experimental clinical study was performed during summer 2016 in Shiraz, Iran. For 13 weeks, 32 Sprague-Dawley rats received one of the 4 diets: Group 1: basal diet mixed with 15% w/w heated oil containing total polar compounds (TPC) = 12.5% (TPC 12.5); Group 2: basal diet with 15% unheated oil used in group 1 (control TPC 12.5); Group 3: basal diet with 15% heated oil with TPC = 35% (TPC 35); and Group 4: basal diet with 15% unheated oil used in group 3 (control TPC 35). At weeks 6 and 13, blood samples were collected for determination of fasting glucose, lipid profile, liver enzymes, and inflammatory and oxidative stress markers. Blood pressure was measured on the 13th week. Histopathological examination of liver slices was performed after euthanization of rats. Statistical analysis was done using the SPSS software. Results: On the 13th week, the TPC 35 group had higher plasma glucose (+40.4 mg/dL, P < 0.05), triglycerides (+13.6 mg/dL, P < 0.05), aspartate transaminase (+34.3 U/L, P < 0.05), interleukin-1β (+453 pg/L, P < 0.01), and blood pressure (+16/5 mmHg, P < 0.05) than the control and higher glucose (+59.3 ng/L, P < 0.001), aspartate transaminase (+55.5 U/L, P < 0.05), total cholesterol (+6.5 mg/dL, P < 0.05), and 8-isoprostane (+8.5 mg/dL, P < 0.05) than the values on week 6. On the 6th week, Low Density Lipoprotein (LDL)-cholesterol was higher in the TPC 35 group than TPC 12.5 (+4.0 mg/dl, P < 0.05) and the level of serum malondialdehyde was higher

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Nutritionally Mediated Oxidative Stress and Inflammation

Cited by 153 publications

References 86 publications

GPR84 and TREM-1 Signaling Contribute to the Pathogenesis of Reflux Esophagitis

GPR84 and TREM-1 Signaling Contribute to the Pathogenesis of Reflux Esophagitis

Post-Match Changes in Muscle Damage Markers among U-21 Soccer Players

The Effects of Heated Oils Used in Fast Food Restaurants on Metabolic, Inflammatory and Oxidative Stress Markers, Blood Pressure, and Liver Histology in Sprague-Dawley Rats

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