Nutritional value, elemental bioaccumulation and antioxidant activity of fruiting bodies and mycelial cultures of an unrecorded wild Lactarius hatsudake from Nanyue mountainous region in China

Zhu, Hongtao; Zheng, Chen; Hu, Youyou; Li, Geqing; Yao, Xiaoqian; Cao, Limin

doi:10.1016/j.foodres.2023.113358

Cited by 2 publications

(3 citation statements)

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“…Oxidative stress is positively associated with hepatocyte injury of NAFLD, while antioxidants could protect the cells or tissues against oxidative injury [ 29 , 30 ]. According to our previous results, LH was an efficient radical scavenger with relatively high antioxidant activity [ 18 ], which might explain why LH protected against HFD-induced liver damage, and it deserves further investigation.…”

Section: Resultsmentioning

confidence: 98%

“…Dried LH was ground using a pulverizer and passed through a 120-mesh sieve to obtain powder. This strain has been identified in previous work, and the contents of total polysaccharides, protein, fat, and ash of LH were 66.43 ± 1.64, 24.10 ± 1.21, 2.50 ± 0.05, and 6.97 ± 0.16 g/100 g d.w. [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

“…In our previous study, we found that the fruiting body of a wild Lactarius hatsudake (LH) contained high concentrations of total carbohydrate, protein, and essential elements, while being low in fat and calories [ 18 ], which revealed its potential use as a functional food ingredient. Although studies have been conducted on many mushrooms and their extracts that could have health impacts on the HFD-fed host, limited studies focus on how LH affects health or modulates the gut microbial composition.…”

Section: Introductionmentioning

confidence: 99%

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Modulatory Effects of Lactarius hatsudake on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice

Zhu,

Hou

2024

Foods

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Lactarius hatsudake (LH), a great wild endemic fungus, contains rich nutritional components with medicinal properties. The effects of LH on body weight, liver weight, liver injury, blood lipids, and gut microbiota in C57BL/6 mice fed a high-fat diet (HFD) for 8 weeks was examined in this research. Though there was no clear impact on weight loss, the findings indicate that LH treatment effectively decreased liver damage caused by HFD, as well as lowered serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol levels. Additionally, it positively influenced gut microbiota to resemble that of mice on a normal diet. In HFD-fed mice, LH markedly boosted the levels of Parabacteroides, unclassified Muribaculaceae, Oscillibacter, and unclassified Oscillospiraceae, while reducing the abundance of Lachnospiraceae NK4A136 group and Erysipelatoclostridium, as well as the ratio of Firmicutes to Bacteroidetes. Further analysis of correlation indicate a possible connection between obesity and gut microbiota. Obesity-related indices show a positive association with unclassified Eubacterium coprostanoligenes group, Blautia, and Erysipelatoclostridium, while displaying a negative correlation with unclassified Muribaculaceae, unclassified Clostridia vadinBB60 group, Helicobacter, Oscillibacter, unclassified Ruminococcaceae, Parabacteroides, and unclassified Oscillospiraceae. The results suggest that LH can help combat obesity and may have the potential to be utilized as a functional food.

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Section: Resultsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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