Foodomics is being consolidated in Food Science through the application and integration of a variety of omics tools (e.g., genomics/trascriptomics, proteomics, metabolomics) together with chemometrics and bioinformatics. Foodomics can greatly improve our understanding of the complex fooddietindividual interplay, involving different Food Science and Nutrition research areas dealing with food composition, food safety, quality and traceability issues, as well as the food impact on individual's health/illness status. Readers of the present chapter will get an overview of the fundamentals, the most recent advances and future perspectives in the different areas of Foodomics.