Nutritional Therapy of Endocrine Disturbances

Biskind, Morton S.

doi:10.1016/s0083-6729(08)61082-1

Cited by 39 publications

(5 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Endogenous estrogen levels in humans vary greatly. Excessive alcohol consumption, age, liver function, nutrient deficiencies (Biskind, 1946), body weight and/or composition (Fishman et al, 1975), and diet (Hill et al, 1980) have all been shown to have profound effects on body estrogen levels and physical manifestations of these levels. The occurrence of coumestrol in human food products thus merits careful scrutiny.…”

Section: Resultsmentioning

confidence: 99%

Analysis of coumestrol, a phytoestrogen, in alfalfa tablets sold for human consumption

Elakovich¹,

Hampton²

1984

J. Agric. Food Chem.

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Analysis of coumestrol, a phytoestrogen, in alfalfa tablets sold for human consumption

Elakovich¹,

Hampton²

1984

J. Agric. Food Chem.

View full text Add to dashboard Cite

“…This fact is interesting in view of the many attempts in recent +years to attribute to hyperestrinism an etiological role in cancer of the uterus (3,4). Certain authors have postulated on the basis of indirect evidence that impairment of the estrogenic metabolic function of the liver was associated with the presence of cancer of the cervix and the fundus (3,4). Our data do not support this hypothesis but indicate that advanced disease of the liver as judged from clinical and morphologic observation may not affect its in vitro metabolic activity on estradiol.…”

Section: Discussionmentioning

confidence: 95%

“…The data also show that this metabolic function was not impaired in three patients with cancer of the cervix and one patient with cancer of the fundus. This fact is interesting in view of the many attempts in recent +years to attribute to hyperestrinism an etiological role in cancer of the uterus (3,4). Certain authors have postulated on the basis of indirect evidence that impairment of the estrogenic metabolic function of the liver was associated with the presence of cancer of the cervix and the fundus (3,4).…”

Section: Discussionmentioning

confidence: 96%

The Metabolism of Estrogens by the Human Liver Studied in Vitro12

Tagnon¹,

Lieberman²,

Schulman³

et al. 1952

J. Clin. Invest.

View full text Add to dashboard Cite

In the preceding paper (1) a method was described which permits the simple calorimetric estimation of microgram amounts of estrogens in the presence of tissues. The results obtained by the use of this method in a study of the in vitro metabolic action of rat liver on 17-p8 estradiol were also reported.In the present paper we are reporting a similar study on human liver. The original motive for this study was to evaluate whether a deficiency of the metabolic function of the liver exists in patients with cancer of the uterus. Patients with this type of cancer and other diseases were studied. METHODSThe procedures described in the preceding paper for the incubation of liver slices, the extraction of the estrogens and the calorimetric method for the measurement of estrogens were used in the present work and found to be applicable without modification to the study of human liver.Human liver specimens were obtained at laparotomy from patients with various surgical diseases. The patients were unselected. The liver specimen was immersed into ice-cold Krebs solution in the operating room, immediately transferred to the laboratory and the incubation experiment begun. The time interval between surgical removal of the specimen and the beginning of the incubation period did not exceed 10 minutes and was comparable to the time interval obtaining in the experiments with rat liver.The liver specimen consisted of a wedge of tissue resected from the anterior border and weighing approximately 2 gms. Sufficient tissue was available in each case to run the metabolic, the control and the blank experiments with slices from the same bloc of tissue.

show abstract

“…In discussing the subject of seasonal variations a detailed report by Biskind (1946) is worthy of note. There appears to be ample experimental evidence to suggest that oestrogens are inactivated by the liver and that undernutrition, particularly involving the Vitamin B group, causes sufficient liver damage to depress this process of inactivation.…”

Section: Discussionmentioning

confidence: 99%