Nutritional Support of Children with Neoplastic Diseases

Coates, Thomas D.; Rickard, Karyl A.; Grosfeld, Jay L.; Weetman, Robert M.

doi:10.1016/s0039-6109(16)44082-x

Cited by 35 publications

(18 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…TPN is expensive and cannot be used without consideration of the cost bene® t. We chose to evaluate children with WT because these patients often have a poor nutritional status. Also, the tumor is potentially curable and constitutes 6± 10% of childhood cancer in African countries [4,9,18]. In this study there was no difference in survival between the two groups.…”

Section: Discussionmentioning

confidence: 46%

“…The results of the basic anthropometry used here were considered a fair indication of the nutritional status of this subgroup of patients because the proportion of poorly nourished children corresponded to the results obtained in a previous local comprehensive survey to determine the nutritional status in all children with cancer [3]. More comprehensive parameters to evaluate nutritional status would ideally include a recently documented weight loss of¸5% of body weight, the serum albumin level, triceps, and subscapular skin-fold thickness and the creatinine height index [4,19]. These data were not available.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nutrition, Morbidity, and Survival in South African Children With Wilms' Tumor

Wessels

Hesseling

Ommeren

et al. 1999

Pediatric Hematology and Oncology

View full text Add to dashboard Cite

Fifty-nine children with Wilms' tumor (WT) were divided into a normal or poorly nourished group according to anthropometric parameters. The 2 groups were compared for morbidity and survival. There was no difference in the median age or stage of disease in the 38 well nourished and 21 poorly nourished children. There was no difference in the number of children in the normal or poorly nourished group who developed a raised urea or creatinine level, febrile episodes, severe stomatitis, varicella, or upper or lower respiratory infections, or who needed intravenous antibiotics, parenteral nutrition, or red cell and platelet transfusions. Projected survival rate was 56 and 74% for normal and poorly nourished children, respectively (p = .3). Poor nutrition at diagnosis, as determined by anthropometry, had no effect on the morbidity of treatment or survival in children with WT. Based on these results, selective dietary supplementation instead of routine intensive parenteral nutritional support for all children with WT is recommended in countries with limited resources.

show abstract

Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Nutrition, Morbidity, and Survival in South African Children With Wilms' Tumor

Wessels

Hesseling

Ommeren

et al. 1999

Pediatric Hematology and Oncology

View full text Add to dashboard Cite

show abstract

“…The improvement in nutritional status, expressed in terms of weight as a percentage of the ideal weight, was de®nitely more impressive in the experimental group (all the children reached their ideal weight) than in the retrospective group. According to Coates et al (1986) the difference in response to nutritional support may be due to differences in age, tumour type, intensity and kind of oncological treatment. These factors are not likely to have caused the difference in nutritional response between the two groups in this study, because there was only a slight difference in age between the two groups, the distribution of tumour types was matched as far as possible and all the children underwent long periods of intensive chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Effects of naso-gastric tube feeding on the nutritional status of children with cancer

Broeder

Lippens

Hof³

et al. 1998

Eur J Clin Nutr

View full text Add to dashboard Cite

Objective: To study the effect of suf®cient energy intake, by means of the protocolized administration of nasogastric tube feeding, on the nutritional status of a child with cancer. Design: A comparative experimental study. Setting: Tertiary care at the Centre for Pediatric Oncology, South East Netherlands, University Hospital, Nijmegen. Subjects: Seven children, newly diagnosed with cancer, were included in the experimental study and all completed the trial period. Fourteen patients were included in the retrospective study. They were randomly chosen from a group of patients previously treated for a malignancy at our department and who had received naso-gastric tube feeding for at least 16 weeks. Intervention: Protocolized (experimental group) vs non-protocolized (retrospective group) administration of naso-gastric tube feeding over a period of 16 weeks. The main difference was the amount of tube feeding administered. In addition to energy from other foods, children in the experimental group received 106 AE 13% of their total daily energy requirements (TDER) by means of tube feeding, whereas children in the retrospective group had received 75 AE 24%. Main outcome measures: Weight as a percentage of weight for height according to the 50th percentile of a healthy reference population ideal weight. Results: Weight, expressed as a percentage of the ideal weight, increased signi®cantly in the experimental group (18.2 AE 8.4; P 0.01) and the retrospective study group (5.2 AE 7.3; P 0.001). However, the increase was statistically signi®cant in favour of the experimental group (P 0.003), in which all the children reached their ideal weight, compared to 21% in the retrospective group. Conclusion: Aggressive protocolized nutritional intervention during the intensive phase of anti-cancer treatment, in the form of naso-gastric tube feeding that provides the child's total daily energy requirements, results in considerable improvement in the nutritional status.

show abstract

“…The incidence of malnutrition at the time of diagnosis has been reported to be as high as 50% in patients with Stage IV neuroblastoma (18). Other pediatric malignancies that have been associated with an increased risk of protein-energy malnutrition include advanced stage Wilms' tumor, Ewing's sarcoma, and relapsed solid tumors or leukemias (11).…”

Section: Discussionmentioning

confidence: 99%

“…Although a trend toward improved survival was observed at one year, no statistical significance was demonstrated. Interpretation of albumin concentrations must take into account adaptive phenomenon that affect serum values, such as dehydration, gastrointestinal losses, preexisting liver disease, and many other confounding variables (18).…”

Section: Discussionmentioning

confidence: 99%

The prognostic significance of basic anthropometric data in children with advanced solid tumors

Lahorra

Ginn‐Pease

King

1989

Nutrition and Cancer

View full text Add to dashboard Cite

In pediatric cancer patients, malnutrition is commonly observed. This may represent the metabolic effect of the primary disease or it may be a consequence of multimodal therapy. This report evaluates the efficacy of using basic anthropometric measurements to predict morbidity during therapy. Twenty children with Wilms' tumor (Stage III, IV, and V) or neuroblastoma (Stage IV) diagnosed at Children's Hospital (Columbus, OH) between January 1983 and December 1985 were evaluated. When compared with the Wilms' tumor patients, the children with neuroblastoma had a significantly lower weight for age at diagnosis. At the completion of therapy, both weight-for-height and weight-for-age measurements were statistically lower in the neuroblastoma group (p less than 0.05). Significant differences were observed between the neuroblastoma and Wilms' tumor patients in the morbidity reported during therapy. Children with neuroblastoma had more frequent hospital admissions, spent a much greater proportion of their treatment time as hospital inpatients, experienced longer delays in therapy, and sustained many more complications. Each of the anthropometric indices was evaluated as a predictor of the complications observed during treatment. In the Wilms' tumor group, the patients with lower weight-for-height percentiles had an increased incidence of incomplete drug infusions, many more complications, more frequent hospital admissions, and an increase in the percentage of time spent as hospital inpatients. In the neuroblastoma group, the anthropometric measurements had no correlation with the subsequent development of complications. Nutritional staging based on anthropometric measurements recorded at diagnosis may be useful in predicting an increased risk of morbidity during therapy in children with Wilms' tumor.

show abstract

Nutritional Support of Children with Neoplastic Diseases

Cited by 35 publications

References 37 publications

Nutrition, Morbidity, and Survival in South African Children With Wilms' Tumor

Nutrition, Morbidity, and Survival in South African Children With Wilms' Tumor

Effects of naso-gastric tube feeding on the nutritional status of children with cancer

The prognostic significance of basic anthropometric data in children with advanced solid tumors

Contact Info

Product

Resources

About