Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D3, and vitamin K1 produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome

Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis

“…Seven of the nine studies identified as multi-nutrient interventions [130,[132][133][134][135][136][137] reported on IGF-1, suggesting little or no effect (MD: 0.60 nmol/L, 95% CI −1.12 to 2.33, I2 0%, 519 participants, Figure 6). Effects did not differ in fixed-effects meta-analysis (MD: 0.60 nmol/L, 95% CI −1.12 to 2.33), suggesting that small study bias is not an issue here.…”

“…For multi-nutrient interventions the composition of the nutrients varied substantially [130,[132][133][134][135][136] with some containing more than 20 different micronutrients [132,137], making it difficult to attribute benefit to any specific micronutrient. A number of studies also included additional protein making it difficult to isolate any specific effects of micronutrients from those of protein [61,132,137,144,145].…”

The effects of improved metabolic risk factors on bone turnover markers after 12 weeks of simvastatin treatment with or without exercise

“…By contrast, the participants in the present study were not hypercholesterolemic, which might have limited the potential effects of cholesterol reduction on bone turnover. Consistent with this idea, others have reported that bone formation increased and resorption decreased in conjunction with improved insulin sensitivity or improved lipid profiles [39,40], but dietary or pharmacological interventions that had limited effects on metabolic risk factors did not impact bone turnover marker outcomes [41,42]. We expected multiple metabolic risk factors (e.g.., lipids, insulin, and glucose) to improve following 12 weeks of statin and/or exercise treatment with associated changes in bone turnover marker outcomes.…”

Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases

“…Treatment with BBR and rho iso-alpha acids, vitamin D3, and vitamin K1 produced a more favorable bone biomarker profile, indicative of healthy bone metabolism in postmenopausal women with MS (Lamb et al, 2011). In a case-control study, BBR is more effective in decreasing the serum MGO levels and InsR through increasing the glycemic control in newly diagnosed T2DM patients (Memon et al, 2018).…”