Nutritional Supplement (NT Factor™) Restores Mitochondrial Function and Reduces Moderately Severe Fatigue in Aged Subjects

Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health

“…In this cross-over clinical trial there was good correspondence between reductions in fatigue and gains in mitochondrial function. After 8 weeks of MLR with 3.9 g per day NTFactor ® , mitochondrial function was significantly improved, and after 12 weeks of NTFactor ® supplementation, mitochondrial function was found to be similar to that found in young healthy adults (26.8% increase, p < 0.0001), while fatigue was reduced 35.5% (p < 0.001) [31]. After 12 weeks of supplement use, subjects were placed on placebo without their knowledge for an additional 12 weeks, and their fatigue and mitochondrial function were again measured.…”

“…After 12 weeks of supplement use, subjects were placed on placebo without their knowledge for an additional 12 weeks, and their fatigue and mitochondrial function were again measured. After the 12-week placebo period, fatigue and mitochondrial function were intermediate between the initial starting values and those found after eight or 12 weeks on the supplement [31]. Similar results on the effects of NTFactor ® on fatigue were found in patients with chronic fatigue syndrome (CFS/ME) and/or fibromyalgia syndrome, Gulf War illness and chronic Lyme disease (reductions from 26% -43%, Table 2).…”

“…With two exceptions [31] [40], the MLR studies reviewed in this contribution were open label, not blinded, placebo-controlled studies. In the cross-over trial by Agadjanyan et al [31], a variety of patients with various diagnoses that had moderate to severe chronic fatigue were studied. The trial could have been improved if patients were enrolled that presented with one primary diagnosis where fatigue was a major symptom, such as chronic fatigue syndrome.…”

“…Although most of the clinical studies presented in Table 2 contained fewer than 50 patients and were open-label, there were significant outcomes in terms of fatigue reduction. For example, the effect of NTFactor ® glycerolphospholipids on fatigue in moderately fatigued subjects was examined to see if mitochondrial function improved with oral administration of the MLR supplement [31]. In this cross-over clinical trial there was good correspondence between reductions in fatigue and gains in mitochondrial function.…”

“…A cross-over trial discussed in the previous section directly related loses or gains in mitochondrial function in individual patients to their fatigue scores [31]. In this case the oral use of NTFactor ® glycerolphospholipids resulted in significant improvements in mitochondrial function in patients with various diagnoses plus chronic fatigue [31]. I have listed the studies that have used MLR, specifically NTFactor ® , to reduce fatigue in Table 2.…”