Nutritional status of human T-lymphotropic virus 1 patients: A retrospective study

Bacelo, Adriana Costa; Cople‐Rodrigues, Cláudia dos Santos; Gonçalves, Juliana; Quintana, Marcel de Souza Borges; Torres, Paloma Ribeiro; Cardoso, Cibele C.; Silva, Marlete Pereira da; Santo, Raquel Espírito; Almeida, Cristina; Silva, Paula Simplício da; Brito, Patrícia Dias de

doi:10.1016/j.clnesp.2019.09.007

Cited by 7 publications

(6 citation statements)

References 13 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The social condition of the areas of origin of these patients itself confers a degree of vulnerability, nutritional deficiencies and barriers for accessing health care which contribute to this result. Although studies have described increased nutritional risk in patients hospitalized for HTLV-1 in Brazil similar to what was observed in this case series (7). Because this is a neglected infection that prevails in countries already affected by poverty and other public health problems, there has been little interest in expanding knowledge about this disease, such as studies to establish the real epidemiology, policy measures to impact its transmission, and therapeutic options to treat the disease.…”

Section: Discussionsupporting

confidence: 68%

“…The clinical manifestations most commonly associated with HTLV-1 infection include T-cell leukemia/ lymphoma (ATLL) and myelopathy associated to HTLV-1 (HAM) (2)(3)(4). Studies carried out mainly in the adult population have reported other clinical manifestations, namely, chronic inflammatory and autoimmune diseases (uveitis, polymyositis, thyroiditis and alveolitis), coinfections by opportunistic microorganisms, malnutrition, depression, and interstitial lung disease (5)(6)(7). The opportunistic microorganisms that have been associated to HTLV-1 include Mycobacterium tuberculosis, Strongyloidisis stercoralis, infective dermatitis associated to Staphylococcus and Streptococcus infections (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Case Series: Pediatric Human T-Lymphotropic Virus Type 1 and Its Clinical Expression

et al. 2022

View full text Add to dashboard Cite

PurposeHuman T-lymphotropic Virus type 1 (HTLV-1) was the first retrovirus to be identified and associated with oncogenic activity. It is estimated that approximately 10–20 million people in the world are infected with it. The clinical manifestations most commonly associated with HTLV-1 infection include T-cell leukemia/lymphoma and myelopathy associated to HTLV-1 infection. The purpose of this study is to describe clinical and demographic characteristics in pediatric patients with HTLV-1 infection.Methodology and PatientsAmbispective case series analysis, with collection of medical records and subsequent description of demographic data (sex, origin, age) and clinical characteristics in 16 patients with HTLV-1 infection were collected. Twelve of these patients were part of an initially reported cohort and four were recruited later in the study. The patients were collected between January 2017 and July 2021 in a pediatric institution in Cali, in a reference hospital in the southwest region of Colombia.ResultsThirteen of a total of sixteen patients came from the Colombian Pacific coast, where nine were with significant nutritional deficiencies. Seven showed dermatological compromise. Eight patients presented images compatible with inflammation and chronic lung injury, and six of the eight patients were with opportunistic infections. Coinfection with other microorganisms was also observed where one case presented with meningeal tuberculosis, another patient presented with simultaneous infections, namely, malaria, leptospirosis and toxoplasmosis, and a third patient presented intestinal parasitosis and soft tissue infection by Streptococcus pyogenes. Three patients had concomitant autoimmune diseases and a fourth patient was highly suspicious of having polymyositis.ConclusionsThe different clinical findings with simultaneous HTLV-1 infection broaden the panorama to suspect infection by this virus. More studies are required to achieve a direct association between structural lung disease, autoimmune diseases, immunodeficiency and HTLV-1 infection. This study aims to raise interest and awareness of an ancient but neglected disease.

show abstract

Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Case Series: Pediatric Human T-Lymphotropic Virus Type 1 and Its Clinical Expression

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Hepatocyte Nuclear Factor 4 alpha (HNF4α), or its variants, and the transcriptional factor Specificity Protein 1 (SP1) were inferred in different databases. Previous studies reported that the IL32 gene has a binding site for these transcriptional factors (39,40). However, we have inferred that the binding site overlaps with the rs45499297 polymorphism.…”

Section: Discussioncontrasting

confidence: 55%

“…Malnutrition has been associated with HIV and HTLV1 (39,40), so it is inferred that genes co-expressed with IL32 are involved with these metabolic pathways, in addition to the fact that this cytokine is modified in malnourished states. This information is essential to understand disease mechanisms, especially in diseases with a high degree of complexity, such as obesity, in which several metabolic pathways are involved in the pathogenesis of the disease.…”

Section: Discussionmentioning

confidence: 99%

Relation of serum IL-32 levels and gene polymorphism rs45499297 with obesity in Mexican patients: a laboratory and in silico analysis

Pérez¹,

Becerra-Ruiz²,

García-Aviña³

et al. 2022

Nutr Hosp

View full text Add to dashboard Cite

show abstract

“…However, studies have shown that HTLV-1 seropositive individuals may present with a broad range of clinical manifestations, including inflammatory syndromes (uveitis, thyroiditis, and alveolitis), neurological symptoms not explained by myelopathy (polyneuropathy, myositis, dysautonomia), and opportunistic co-infections (strongyloidiasis, tuberculosis, and aspergillosis) 7 . Some studies have even shown that HTLV-1 infection may be associated with clinical depression and nutritional deficiencies 16,17 . However, the vast majority of patients that are HTLV-1 positive remain asymptomatic, and the precise mechanisms underlying the development of symptoms in a subgroup of patients remain to be determined 14 .…”

Section: Introductionmentioning

confidence: 99%

Clinical profile of human T-lymphotropic virus type I: a forgotten infection in pediatrics

Mejía-Mertel

Gómez-Banoy

Hernández

et al. 2020

Infect

View full text Add to dashboard Cite

The Human T-lymphotropic virus type 1 (HTLV-1), a retrovirus with oncogenic properties, affects around ten to twenty million people worldwide. The most common disorders associated with HTLV-1 infection are T-cell leukemia/lymphoma (ALT) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Studies have reported other clinical manifestations in HTLV-1 seropositive patients, including inflammatory disorders, co-infections with opportunistic agents, and pulmonary diseases. Objective: Here, we aim to describe a cohort of juvenile patients with confirmed HTLV-1 infection that showed clinical manifestations other than neurological symptoms. Methodology and patients: Retrospective analysis of clinical data describing background and clinical findings of 12 juvenile patients with confirmed HTLV-1 infection, attended during January 2018 to February 2020 in a pediatric referral hospital in Cali, Colombia. Results: 11 out 12 patients were from Colombia´s Pacific coast, 10 suffered from significant nutritional deficiencies. Six exhibited dermatological findings, 3 compatible with infective dermatitis. None of the cases exhibited clinical or laboratory findings suggesting ALT or HAM/TPS. Eight patients had structural lung disease assessed by chest Computed Tomography (CT) scans; 4 of them tested positive for galactomannan antigen in bronchoalveolar fluid suggesting pulmonary aspergillosis, and 2 others exhibited a positive PCR testing for tuberculosis. Three patients were diagnosed with autoimmune disorders; 1 patient with Crohn´s Diseases, 1 case of autoimmune thrombocytopenic purpura, and a patient with Vogt-Koyanagi-Harada syndrome (non-granulomatous uveitis). Conclusions: There is a broad range of clinical manifestations in pediatric HTLV-1 patients, and the clinician should consider structural pulmonary disease, opportunistic co-infections and autoimmune disorders in the diagnostic algorithm.

show abstract

Nutritional status of human T-lymphotropic virus 1 patients: A retrospective study

Cited by 7 publications

References 13 publications

Case Series: Pediatric Human T-Lymphotropic Virus Type 1 and Its Clinical Expression

Case Series: Pediatric Human T-Lymphotropic Virus Type 1 and Its Clinical Expression

Relation of serum IL-32 levels and gene polymorphism rs45499297 with obesity in Mexican patients: a laboratory and in silico analysis

Clinical profile of human T-lymphotropic virus type I: a forgotten infection in pediatrics

Contact Info

Product

Resources

About