Nutritional Status Influences Plasma Fibrinogen Concentration

James, Santhamma; Vorster, Hester H.; Venter, C S; Kruger, Herculina S.; Nell, Theo; Veldman, Frederick Johannes; Ubbink, Johan B.

doi:10.1016/s0049-3848(00)00197-3

Cited by 30 publications

(32 citation statements)

References 15 publications

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“…The lack of increase in fibrinogen, PAI-1 and cr-PWV levels in the infected group may be related to the possible short duration of the infection, as is also speculated in the study of James et al 47. This is confirmed by the tendency of increased (although not statistically significant) fibrinogen levels in the nadir CD 4 cell count group.…”

Section: Discussionsupporting

confidence: 56%

“…However, in our study neither the PAI-1 activity nor fibrinogen levels were increased in the HIV-infected subjects, indicating no signs of a prothrombotic state. Our findings are in agreement with the findings of James et al ., who found that HIV infection was not associated with the fibrinogen concentration in Africans 47. It is known that black South Africans of African ancestry have high levels of fibrinogen, 48 and it may therefore be that ethnic effects on plasma fibrinogen may have masked the potential effect of HIV infection.…”

Section: Discussionmentioning

confidence: 98%

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Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?

Fourie¹,

Rooyen²,

Pieters³

et al. 2011

CardioVascular Journal of Africa

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The chronic infection status suffered by HIV-infected individuals promotes chronic arterial inflammation and injury, which leads to dysfunction of the endothelium, atherosclerosis and thrombosis. Although HIV-1 subtype C is prevalent in South Africa and accounts for almost a third of the infections worldwide, this subtype differs genetically from HIV-1 subtype B on which the majority of studies have been done. The objective of this study was to assess whether newly identified, never-treated, HIV-1-infected South African participants showed signs of endothelial dysfunction, accelerated atherosclerosis and increased blood coagulation.We compared 300 newly diagnosed (never antiretroviral-treated) HIV-infected participants to 300 age-, gender-, body mass index- and locality-matched uninfected controls. Levels of high-density lipoprotein cholesterol (HDL-C), triglycerides, interleukin-6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), fibrinogen and plasminogen activator inhibitor-1 (PAI-1), and carotid radialis pulse wave velocity (cr-PWV) were determined. The HIV-infected participants showed lower HDL-C and higher IL-6, CRP, ICAM-1 and VCAM-1 levels compared to the uninfected controls. No differences in fibrinogen and PAI-1 levels were detected. A continuous positive trend of increasing age with cr-PWV was detected in the HIV-infected group.Our findings suggest inflammatory injury of the endothelium, pointing to endothelial dysfunction of never-treated HIV-1-infected South Africans of African ancestry. Although no indication of a prothrombotic state could be detected, there was an indication of accelerated vascular aging and probable early atherosclerosis in the older HIV-infected participants.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 98%

Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?

Fourie¹,

Rooyen²,

Pieters³

et al. 2011

CardioVascular Journal of Africa

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“…Plasma PLP levels are known to be inversely related to TNF-a production and other inflammatory cytokines in RA (17) . It has also been reported that low plasma PLP concentrations are inversely related to both plasma fibrinogen (83) and CRP (11,13) , with a robust and independent association of Vitamin B 6 , CVD and inflammation …”

Section: Yesmentioning

confidence: 92%

“…Indeed, a mild deficiency of vitamin B 6 may be associated with an increased risk, not only of atherosclerosis, but also of other chronic inflammatory diseases such as RA (18,87) and inflammatory bowel diseases (16) . A number of studies have highlighted the relationship between PLP and inflammation, showing an inverse association between vitamin B 6 and major markers of inflammation, including plasma fibrinogen concentration (83) , erythrocyte sedimentation rate and CRP (13) . In the population-based Framingham Heart Study cohort, the association between PLP and CRP was strong and independent of other major biomarkers related to vitamin B 6 metabolism (13) , supporting a possible role for plasma PLP in inflammatory processes.…”

Section: Yesmentioning

confidence: 99%

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Lotto

Friso

2011

Br J Nutr

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The objective of the present review is to highlight the relationship between low vitamin B 6 status and CVD through its link with inflammation. While overt vitamin B 6 deficiency is uncommon in clinical practice, increasing evidence suggests that marginal vitamin B 6 deficiency is rather frequent in a consistent proportion of the population and is related to an increased risk of inflammation-related diseases. Ample evidence substantiates the theory of atherosclerosis as an inflammatory disease, and low plasma vitamin B 6 concentrations have been related to increased CVD risk. Several studies have also shown that low vitamin B 6 status is associated with rheumatoid arthritis and chronic inflammatory bowel diseases, both of which hold an underlying chronic inflammatory condition. Furthermore, the inverse association observed between inflammation markers and vitamin B 6 supports the notion that inflammation may represent the common link between low vitamin B 6 status and CVD risk. In addition to the epidemiological evidence, there are a number of cell culture and animal studies that have suggested several possible mechanisms relating impaired vitamin B 6 status with chronic inflammation. A mild vitamin B 6 deficiency characterises, in most cases, a subclinical at-risk condition in inflammatory-linked diseases which should be addressed by an appropriate individually tailored nutritional preventive or therapeutic strategy.

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“…The main aim of the present study was to examine the interrelation of the main hypertension risks: urbanisation, 3 age, 2 smoking, 9 alcohol consumption, 10 four measurements of lipid profile, 11,12 obesity, 13 cardiovascular variables, 14 certain dietary factors, [15][16][17][18][19][20] plasma fibrinogen 21 and fasting insulin 22 in a black South African population by combining the results of the THUSA and THUSA BANA studies.…”

Section: Introductionmentioning

confidence: 99%

Factor analysis of possible risks for hypertension in a black South African population

et al. 2003

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To date only a small number of studies have investigated the pattern of associations within a set of hypertension risks. The objective of this study was therefore to examine the interrelation of main hypertension risks in an African population by using factor analysis in order to detect underlying risk patterns. Subjects aged 16-70 years (N ¼ 963) were recruited from 37 randomly selected sites throughout the North West Province during 1996-1998. Exclusion criteria were pregnancy, lactation, casual visitors, drunkenness and treatment for chronic diseases, such as hypertension. Subjects with blood pressures exceeding 140/90 mmHg were classified as hypertensive. Children aged 10-15 years were also recruited from 30 randomly selected schools during 2000-2001 (N ¼ 694). Children were classified as hypertensive when an average systolic or diastolic blood pressure greater than or equal to the 90th percentile for age and sex was encountered, while correcting for height. The following hypertension risks were measured: urbanisation, obesity, plasma fibrinogen, lipids, insulin, serum gamma glutamyl-transferase, dietary intake, smoking and alcohol consumption. From 23 risks the factor analysis disclosed five factors that explained 56.2% of the variance in the male and 43.5% of the variance in the female group: an urban malnutritional phenomenon, the metabolic syndrome X, a hypercholesterolaemic and obesity complex, an alcoholic hypertriglyceridaemia, and central and peripheral cardiovascular hypertensive effects. In conclusion, South Africans migrating from rural to urban areas adapt to a new lifestyle with numerous risks, resulting in conditions like malnutrition, the metabolic syndrome X, dyslipidaemia, alcoholism, obesity and increased peripheral vascular resistance. For successful prevention of hypertension in a population in transition, a whole risk pattern should be corrected, rather than an individual risk by implementing lifestyle modification programmes.

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Nutritional Status Influences Plasma Fibrinogen Concentration

Cited by 30 publications

References 15 publications

Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?

Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Factor analysis of possible risks for hypertension in a black South African population

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Nutritional Status Influences Plasma Fibrinogen Concentration

Cited by 30 publications

References 15 publications

Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?

Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?

Vitamin B6: a challenging link between nutrition and inflammation in CVD

Factor analysis of possible risks for hypertension in a black South African population

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Product

Resources

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Vitamin B₆: a challenging link between nutrition and inflammation in CVD