Nutritional status at diagnosis is prognostic for pharyngeal cancer patients: a retrospective study

Wu, Chongsheng; Lin, Yu‐Hsuan; Lo, Wu‐Chia; Cheng, Ping‐Chia; Hsu, Wan‐Lun; Chen, Yong‐Chen; Shueng, Pei‐Wei; Hsieh, Chen‐Hsi; Liao, Li‐Jen

doi:10.1007/s00405-021-07222-5

Cited by 16 publications

(23 citation statements)

References 25 publications

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“…For example, papers on breast, endometrial, and cervical cancer only considered female patients, while papers on prostate cancer and one paper on esophageal cancer exclusively male populations [48,[61][62][63][64][65][66]. Two papers on pharyngeal cancer had primarily male populations [49,67]. Amongst those with female only populations, three of the four papers showed HALP to have prognostic benefit, with only Njoku et al, not concluding in favor of HALP.…”

Section: Halp and Sexmentioning

confidence: 99%

“…There have been 2 studies to date investigating HALP’s prognostic ability in the setting of pharyngeal cancer, both being published in 2022. The first paper to do so was published by Wu et al, and considered 319 mostly male pharyngeal cancer patients, including nasopharyngeal, oropharyngeal, and hypopharyngeal carcinoma [ 67 ]. They chose a cut off of 44 based on the mean HALP of 44.2 in the sample.…”

Section: Introductionmentioning

confidence: 99%

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What is hemoglobin, albumin, lymphocyte, platelet (HALP) score? A comprehensive literature review of HALP’s prognostic ability in different cancer types

et al. 2023

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Since its inception, the Hemoglobin, Albumin, Lymphocyte, Platelet Score (HALP) has gained attention as a new prognostic biomarker to predict several clinical outcomes in a multitude of cancers. In our review, we searched PubMed for articles between the first paper on HALP in 2015 through September 2022, yielding 32 studies in total that evaluated HALP's association with various cancers, including Gastric, Colorectal, Bladder, Prostate, Kidney, Esophageal, Pharyngeal, Lung, Breast, and Cervical cancers, among others. This review highlights the collective association HALP has with demographic factors such as age and sex in addition to TNM staging, grade, and tumor size. Furthermore, this review summarizes HALP's prognostic ability to predict overall survival, progression-free survival, recurrence-free survival, among other outcomes. In some studies, HALP has also been able to predict response to immunotherapy and chemotherapy. This review article also aims to serve as a comprehensive and encyclopedic report on the literature that has evaluated HALP as a biomarker in various cancers, highlighting the heterogeneity surrounding HALP's utilization. Because HALP requires only a complete blood count and albumin - already routinely collected for cancer patients - HALP shows potential as a cost-effective biomarker to aid clinicians in improving outcomes for immuno-nutritionally deficient patients.

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Section: Halp and Sexmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

What is hemoglobin, albumin, lymphocyte, platelet (HALP) score? A comprehensive literature review of HALP’s prognostic ability in different cancer types

et al. 2023

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“… 47 A retrospective study with 319 pharyngeal cancer patients including nasopharyngeal carcinoma, oropharyngeal carcinoma and hypopharyngeal carcinoma indicated that HALP score was an independent factor for OS. 48 However, the number of patients included in the article was small and each type of tumor was not analyzed separately. In the present study, more patients were included.…”

Section: Discussionmentioning

confidence: 99%

Nomogram Based on Hemoglobin, Albumin, Lymphocyte and Platelet Score to Predict Overall Survival in Patients with T3-4N0-1 Nasopharyngeal Carcinoma

Zhao¹,

Liang²,

Chen³

et al. 2023

JIR

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Purpose There is still uncertainty regarding the prognosis of nasopharyngeal carcinoma (NPC) based on hemoglobin, albumin, lymphocytes, and platelets (HALP) score. The aim of this study was to build and verify a nomogram using HALP score to investigate the prognostic value of NPC and identify low-risk patients in T3-4N0-1 NPC to guide treatment options. Patients and methods A total of 568 NPC patients with stage T3-4N0-1M0 were recruited in the study, who were given either concurrent chemoradiotherapy (CCRT) or induction chemotherapy (IC) plus CCRT. The prognostic factors of overall survival (OS) were picked by Cox proportional hazards regression analysis to generate a nomogram, which appraised by discrimination, calibration and clinical utility. Patients were stratified according to risk scores calculated by the nomogram, and compared to the 8th TNM staging system using the Kaplan–Meier methods. Results Multivariate analysis showed that TNM stage, Epstein–Barr virus DNA (EBV DNA), HALP score, lactate dehydrogenase-to-albumin ratio (LAR) and systemic inflammatory response index (SIRI) were independent prognostic indicators for OS, and these factors contained in the nomogram. The nomogram demonstrated a significant enhancement over the 8th TNM staging system in terms of assessing OS (C-index, 0.744 vs 0.615 in the training cohort, P < 0.001; 0.757 vs 0.646 in the validation cohort, P = 0.002). Calibration curves displayed good agreement and the stratification in high-risk and low-risk groups resulted in a significant divergence of Kaplan–Meier curves for OS (P < 0.001). In addition, the decision analysis (DCA) curves confirmed satisfactory discriminability and clinical utility. Conclusion The HALP score was an independent prognostic factor for NPC. The prognostic function of the nomogram for T3-4N0-1 NPC patients was more accurate compared to the 8th TNM system, facilitating personalized treatment planning.

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“…In addition, there have been only two publications regarding the effect of nasal airflow discontinuation in the development of CRS, in which the ununited results were shown in two publications. 11,12 In the previous literature, no studies were conducted with TL patients with a minimal time interval of 3 years following TL to see the effect of nasal airflow cessation, lacking a long-term outcome. Also, up to the authors' knowledge, no previous studies with TL patients reported changes in the paranasal sinus volumes following TL.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the previous publications did not meet a consensus in terms of whether atrophy or hypertrophic changes in the nasal mucosa following TL. In addition, there have been only two publications regarding the effect of nasal airflow discontinuation in the development of CRS, in which the ununited results were shown in two publications 11,12 …”

Section: Introductionmentioning

confidence: 99%

Impact of long‐term nasal airflow deprivation on sinonasal structures and chronic rhinosinusitis in total laryngectomy patients

Park,

Bae,

Kim

et al. 2024

Laryngoscope Investig Oto

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ObjectiveTotal laryngectomy (TL) patients are good models in which to evaluate the effects of nasal airflow cessation on the sinonasal tract. Here, we evaluated changes in sinonasal structures and association with sinus opacification in the computed tomography (CT) images 3 years post‐TL.MethodsPatients who underwent TL from 2005 to 2017 in a teaching academic center were reviewed retrospectively. Patients with a final follow‐up CT taken less than 3 years after TL, tracheoesophageal puncture, inadequate CT image, or history of sinonasal surgery were excluded. The control group included patients who underwent a partial laryngectomy or hypopharyngectomy without requiring a tracheotomy for more than a month. Altogether, 45 TL patients and 38 controls were selected. The volume of all four paranasal sinuses, inferior turbinate soft tissue volume (ITSTV), maxillary sinus natural ostium (MSNO) mucosal width, and Lund–Mackay scores (LMS) were measured on preoperative and postoperative CT scans.ResultsThe mean duration between surgery and the final CT scan was 6.3 ± 2.4 and 5.5 ± 2.3 years for the TL and control groups, respectively. Neither group showed significant changes in the four paranasal sinuses' volume or MSNO mucosa width. The ITSTV decreased significantly, from 4.6 ± 1.3 to 2.8 ± 1.1 mL (p < .001), in the TL group, regardless of the presence of nasal septal deviation, showing ITSTV reduction on both concave and convex sides. By contrast, the control group showed no significant changes in ITSTV. Postoperative LMS changes in both groups were insignificant. The number of patients with LMS aggravation or alleviation was the same in both groups, regardless of preoperative sinus opacification.ConclusionsParanasal sinus structures and sinus opacification are not affected significantly by nasal airflow cessation; however, the inferior turbinate mucosa is affected by long‐term discontinuation of nasal airflow.Level of Evidence4 (case–control study).

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Nutritional status at diagnosis is prognostic for pharyngeal cancer patients: a retrospective study

Cited by 16 publications

References 25 publications

What is hemoglobin, albumin, lymphocyte, platelet (HALP) score? A comprehensive literature review of HALP’s prognostic ability in different cancer types

What is hemoglobin, albumin, lymphocyte, platelet (HALP) score? A comprehensive literature review of HALP’s prognostic ability in different cancer types

Nomogram Based on Hemoglobin, Albumin, Lymphocyte and Platelet Score to Predict Overall Survival in Patients with T3-4N0-1 Nasopharyngeal Carcinoma

Impact of long‐term nasal airflow deprivation on sinonasal structures and chronic rhinosinusitis in total laryngectomy patients

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