Nutritional status as a predictor of adverse events and survival in pediatric autologous stem cell transplant

Kranjčec, Izabela; Matijašić, Nuša; Mašić, Mario; Švigir, Alen; Jakovljević, Gordana; Bolanča, Ante

doi:10.1080/08880018.2020.1797254

Cited by 3 publications

(1 citation statement)

References 64 publications

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“…On the other side, in children and young adults diagnosed with acute leukemia who underwent umbilical cord blood transplantation, a BMI less than the fifth percentile at the time of transplantation was associated with higher incidence of acute grade II to IV aGvHD ( 31 , 32 ). In the auto HSCT setting, a BMI <5th percentile at the time of transplantation was significantly associated with increased incidence of electrolyte disorders, mainly hypokalemia, and severe mucositis ( 33 ). Other conflicting data are reported by Aplenc et al who retrospectively analyzed 3,687 children from the Center for International Blood and Bone Marrow Transplant Research (CIBMTR) database receiving cyclophosphamide-based conditioning regimens for leukemias.…”

Section: The Relationship Between Nutritional Status and Clinical Out...mentioning

confidence: 99%

The emerging role of nutritional support in the supportive care of pediatric patients undergoing hematopoietic stem cell transplantation

et al. 2023

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Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) represents a potentially curative strategy for many oncological, hematological, metabolic, and immunological diseases in children. The continuous effort in ameliorating supportive care represents one of the cornerstones in the improvement of outcome in these patients. Nowadays, more than ever nutritional support can be considered a key feature. Oral feeding in the early post-transplant period is severely impaired because of mucositis due to conditioning regimen, characterized by, mainly by vomiting, anorexia, and diarrhea. Gastrointestinal acute graft-versus-host-disease (GvHD), infections and associated treatments, and other medications, such as opioids and calcineurin inhibitors, have also been correlated with decreased oral intake. The consequent reduction in caloric intake combined with the catabolic effect of therapies and transplantation-related complications with consequent extended immobilization, results in a rapid deterioration of nutritional status, which is associated with decreased overall survival and higher complication rates during treatment. Thus, nutritional support during the early post-transplantation period becomes an essential and challenging issue for allo-HSCT recipients. In this context, the role of nutrition in the modulation of the intestinal flora is also emerging as a key player in the pathophysiology of the main complications of HSCT. The pediatric setting is characterized by less evidence, considering the challenge of addressing nutritional needs in this specific population, and many questions are still unanswered. Thus, we perform a narrative review regarding all aspects of nutritional support in pediatric allo-HSCT recipients, addressing the assessment of nutritional status, the relationship between nutritional status and clinical outcomes and the evaluation of the nutritional support, ranging from specific diets to artificial feeding.

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Section: The Relationship Between Nutritional Status and Clinical Out...mentioning

confidence: 99%

The emerging role of nutritional support in the supportive care of pediatric patients undergoing hematopoietic stem cell transplantation

et al. 2023

View full text Add to dashboard Cite

show abstract

Nutritional status and body mass index before hematopoietic stem cell transplantation (HSCT) and associated outcomes: a rapid review

Sauls,

Buro,

Montgomery

et al. 2023

Support Care Cancer

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Enteral nutrition optimization program for children undergoing blood & marrow transplantation: A quality improvement project

Murphy,

Cooke,

Symons

et al. 2024

Journal of Pediatric Nursing

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Nutritional status as a predictor of adverse events and survival in pediatric autologous stem cell transplant

Cited by 3 publications

References 64 publications

The emerging role of nutritional support in the supportive care of pediatric patients undergoing hematopoietic stem cell transplantation

The emerging role of nutritional support in the supportive care of pediatric patients undergoing hematopoietic stem cell transplantation

Nutritional status and body mass index before hematopoietic stem cell transplantation (HSCT) and associated outcomes: a rapid review

Enteral nutrition optimization program for children undergoing blood & marrow transplantation: A quality improvement project

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