Nutritional status and prognosis of head and neck cancer disease

Büntzel, Jens; Krauß, Tina; Büntzel, Heike; Küttner, K; Fröhlich, D; Oehler, W; Glatzel, M.; Wackes, Matthias; Putziger, Jens; Micke, Oliver; Kisters, Klaus; Mücke, Ralph

doi:10.5414/te0x1235

Cited by 4 publications

(5 citation statements)

References 9 publications

(10 reference statements)

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“…Difference in malnutrition rates between entities—ranging in our cohort from 11.76% in breast cancer patients to 48.44% in patients with hematological neoplasia—is not an uncommon phenomenon. Malnutrition rates of lung (43.60%) and head–neck cancer (31.82%) in our study were similar to the previous data [ 20 , 21 , 22 , 23 , 24 ]. For patients with hematological neoplasia, the malnutrition rate in our study was higher than the data found in the literature [ 18 , 19 , 24 , 25 ].…”

Section: Discussionsupporting

confidence: 92%

Why We Should Look at Dinner Plates: Diet Changes in Cancer Patients

et al. 2023

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Objective: Malnutrition is often underestimated in the context of cancer therapy: the dietary trends initiated by patients after diagnosis are usually neither known to nor evaluated by the medical staff. Here, we propose a combined screening instrument evaluating malnutrition and dietary trends. Methods: The validated screening tool NRS-2002 was combined with a four-item questionnaire assessing whether (1) patients preferred certain foods, (2) avoided certain foods, (3) used dietary supplements or followed a special diet since the time of cancer diagnosis. The screening tool was routinely used by cancer patients in the daily practice of three oncological departments. The presented analysis was performed retrospectively and anonymized. Results: Overall, 102 cancer patients undergoing systemic therapy (CP), 97 undergoing radiation therapy (RP), and 36 head–neck cancer patients (HNP) were screened. The CP cohort showed a higher rate of malnutrition (50.00%) than the HNP (28.13%) or RP (26.80%) cohort. Overall, diet changes were observed in 33.63% of all patients. Avoiding meat, stimulants, or hard and edgy food was often mentioned in free text answers, while patients reported a preference for fruit and vegetables. Nutritional supplements were used by 28.76% of the patients. While dietary changes were common, only 6.64% of the patients mentioned adhering to a specific cancer diet. Conclusion: Malnutrition is still underestimated nowadays. Diet trends, especially avoiding certain foods, are common in cancer patients, while adhering to a specific cancer diet is an exception. Diet trends should be assessed and addressed to avoid or aggravate malnutrition.

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Section: Discussionsupporting

confidence: 92%

Why We Should Look at Dinner Plates: Diet Changes in Cancer Patients

et al. 2023

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“…Previous studies have reported a close relationship between copper dysregulation and the initiation and development of HNSCC. Systemic copper dysregulation is common in cancer patients, [94] including those with thyroid cancer, [95] gynecological cancer, [96] breast cancer, [97] gastrointestinal cancer, [98] gallbladder cancer, [99] lung cancer, [100] prostate cancer, [101] and HNSCC [102,103] (Table 2). Cross-sectional studies have generally shown that copper levels in serum, saliva, or cancer tissues are higher in patients with oral squamous cell carcinoma (OSCC), nasopharyngeal carcinoma (NPC), laryngeal squamous cell carcinoma (LSCC), and oral potentially malignant diseases (OPMD) including oral submucous fibrosis (OSMF), oral lichen planus (OLP) and oral leukoplakia (OL), compared to healthy controls [104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123] (Table 2).…”

Section: Copper Content In Hnscc Patientsmentioning

confidence: 99%

“…Büntzel et al found that the level of serum copper was higher, and the activity of endogenous glutathione peroxidase (GSH-Px) was lower in patients with advanced HNSCC than in healthy controls. [102] GSH-Px oxidizes reduced glutathione (GSH) to oxidized glutathione disulfide (GSSG). And GSH is an endogenous copper chelator.…”

Section: Copper Content In Hnscc Patientsmentioning

confidence: 99%

Section: Copper In Hnsccmentioning

confidence: 99%

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Copper‐Related Cell Death and the Role of Copper in Head and Neck Squamous Cell Carcinoma and Therapeutic Strategies

Zhang,

Wu,

Wang

et al. 2024

Advanced Therapeutics

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As an essential mineral element for the human body, copper (Cu) is necessary for various physiological functions. Excess or deficiency of copper causes cytotoxicity and damages the body. Thus, strict regulatory mechanisms are required to maintain copper homeostasis. Copper correlates closely to many forms of cell death. A recent study found that copper‐dependent cell death, known as cuproptosis, is different from all other known forms of cell death. This discovery helps us further understand the role of copper in cytotoxicity. Copper dysregulation occurs in a variety of malignancies, including head and neck squamous cell carcinoma (HNSCC), which is the eighth most common malignancy worldwide. This may increase the risk of HNSCC from a population perspective. Further exploring molecular mechanisms of copper in HNSCC will contribute to provide new therapeutic opportunities. Here we review the physiological metabolism and functions of copper, as well as copper‐related cell death. We focus on the research advances of copper in HNSCC, including the epidemiology and molecular mechanisms, as well as therapeutic strategies targeting copper homeostasis.This article is protected by copyright. All rights reserved

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“…Weight loss, BMI, loss of muscle mass and biochemical examinations indicative of nutritional status are important predictive factors to consider in HNSCC patients. These patients are among the most vulnerable ones in terms of cancer-related malnutrition (defined as an unwanted weight loss of >5% (or >10%) in three (or six) months, or a reduction of BMI to less than 21 kg/m 2 [2]). Malnutrition in patients with HNSCC is a concern, as it is associated with increased treatment toxicity, number of admissions, health care costs, morbidity, and mortality [3].…”

Section: Malnutrition and Nutritional Interventionsmentioning

confidence: 99%

Exercise and Nutrition Interventions in Head and Neck Cancer

Bossi

Stucchi

2023

Critical Issues in Head and Neck Oncology

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Overall Survival (OS) and late quality of life of patients with locally advanced, HPV-negative Head and Neck Squamous Cell Cancer (HNSCC) are not satisfactory. Nutritional status at the beginning of both surgical and non-surgical treatment with curative intent has been linked to OS and quality of life. Weight loss, body-mass index, functional parameters, and biochemical examinations have been associated with the risk of treatment-related adverse events, mortality, quality of life and outcome. Moreover, there is a strong need for effective preventive approaches that could be implemented after completion of curative treatment to reduce recurrences, second tumors and improve quality of life. Aerobic exercise training, which is known to stimulate the immune system, and nutritional interventions represent easy, acceptable and reproducible methods to increase immune and nutritional competence, impacting thus on the aforementioned objectives. Participating in exercise training programs has been well accepted by patients with HNSCC, underlining the feasibility of such an intervention. There are also immunological arguments to promote an adequate physical activity in HNSCC patients. Baseline and after treatment immune competence of HNSCC should be weighted, as it may impact on cancer recurrence and OS. Patients with HNSCC have significantly lower absolute numbers of CD3+, CD4+ and CD8 + T cells than normal controls, and lymphocyte counts, neutrophil/lymphocyte ratio and the prognostic nutritional index (PNI) are associated with prognosis. Aerobic exercise training prevents immune senescence, and therefore may prevent cancer development. The immune system activity is accompanied by an increased rate of metabolism, requiring energy sources, substrates for biosynthesis and regulatory molecules, which are ultimately derived from the diet. Hence, an adequate supply of a wide range of nutrients is essential to support the immune system to function optimally. Therefore, a regular nutritional counselling combined with personalized exercise training is a simple and very cheap way that could improve patient’s nutritional condition and immunological function, and ultimately impact on survival and quality of life. There is a strong need for well conducted clinical trials aimed at evaluating, in homogeneous groups of HNSCC patients, the impact of nutritional interventions (also comprising immunonutrition) and physical exercise. The evaluation of surrogate endpoints like circulating immune cells should also be explored to identify feasible and effective interventions. Integrating these interventions within immunotherapy approaches represents another area deserving further studies.

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Nutritional status and prognosis of head and neck cancer disease

Cited by 4 publications

References 9 publications

Why We Should Look at Dinner Plates: Diet Changes in Cancer Patients

Why We Should Look at Dinner Plates: Diet Changes in Cancer Patients

Copper‐Related Cell Death and the Role of Copper in Head and Neck Squamous Cell Carcinoma and Therapeutic Strategies

Exercise and Nutrition Interventions in Head and Neck Cancer

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