Nutritional status and postoperative outcomes in patients with gastrointestinal cancer in Vietnam: a retrospective cohort study

Loan, Bui Thi Hong; Nakahara, Shinji; Tho, Bui An; Đăng, Trần Ngọc; Anh, Lê Ngoc; Huy, Nguyen Do; Ichikawa, Masao

doi:10.1016/j.nut.2017.11.027

Cited by 30 publications

(37 citation statements)

References 25 publications

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“…Moreover, our data suggested that the interventions had a considerable beneficial effect on the nutritional status of the patients. The baseline malnutrition rate in both groups was substantially high, at approximately 80% according to the PG-SGA, which was consistent with previous studies [ 33 , 34 , 35 ]. Meanwhile, the BMI results revealed that the malnutrition rates at baseline in both groups were only over 30%, which was much lower than that of the PG-SGA.…”

Section: Discussionsupporting

confidence: 92%

Nutritional Intervention Improves Nutrition Outcomes in Stomach and Colon Cancer Patients Receiving Chemotherapy: Finding from a Quasi-Experiment in Vietnam

et al. 2021

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Background: Evidence on the effects of nutritional interventions on gastrointestinal cancer patients receiving chemotherapy is not well documented. This study aims to assess the effects of nutritional intervention in patients diagnosed with stomach and colon cancer receiving chemotherapy in Vietnam. Methods: A quasi-experiment with intervention and control groups for pre- and post-intervention was carried out in cancer patients receiving chemotherapy in a university hospital in Vietnam. Patients in the intervention group were provided nutritional counseling, personalized specific dietary advice, and received oral nutrition supplements (ONSs) while patients in the control group only received nutrition counseling. Results: The weight in the intervention and control group after 2 months increased significantly by 1.4 ± 2.6 kg and 0.4 ± 2.3 kg, respectively. Muscle mass increased by 1.2 ± 4.1 cm in the intervention group, while those in the control group decreased by 0.55 ± 2.77 cm. There was no statistical significance between two groups after intervention in terms of Mid–Upper Arm Circumference (MUAC) and percentage of fat. The percentage of malnutrition based on the Scored Patient-Generated Subjective Global Assessment (PG-SGA) and Body Mass Index (BMI) declined after the intervention in both groups. According to the average treatment effect on the treated (ATT) using the propensity score matching and DiD method, participants receiving the intervention were more likely to have a higher score of weight (Coef = 0.84; 95%CI = 0.47; 2.16) and muscle mass (Coef = 1.08; 95%CI = 0.09; 2.06) between pre- and post-intervention. By contrast, the PG-SGA scores on treated participants were more likely to decrease after the intervention (Coef = −1.28; 95%CI = −4.39; −0.84). After matching, being female, living in rural areas, or having stomach cancer were still positively related to being moderately/severely malnourished by the PG-SGA, and these findings were statistically significant (p < 0.05). Conclusion: The nutritional interventions had a positive effect on weight gain, muscle mass, and reduced malnutrition. Further studies with a longer follow-up duration are needed to confirm the effects of the intervention.

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Section: Discussionsupporting

confidence: 92%

Nutritional Intervention Improves Nutrition Outcomes in Stomach and Colon Cancer Patients Receiving Chemotherapy: Finding from a Quasi-Experiment in Vietnam

et al. 2021

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“…Malnutrition in cancer patients was common and could lead to increased complications and mortality and prolonged hospital stay [3,4,27].…”

Section: Discussionmentioning

confidence: 99%

Validation of the Efficacy of the NUTRISCORE for Nutritional Screening of Cancer Patients in China

Kang

Shi

et al. 2021

Preprint

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Background: Malnutrition is common in cancer patients. The NUTRISCORE was a newly developed cancer-specific nutritional screening tool and validated by reference to the Patient-Generated Subjective Global Assessment (PG-SGA) and Malnutrition Screening Tool (MST) in Spain. We aimed to evaluate the performance of NUTRISCORE, MST, and PG-SGA in estimating the risk of malnutrition in Chinese cancer patients.Methods: Data from an open parallel and multicenter cross-section study in 29 clinical teaching hospitals in 14 Chinese cities were used. Cancer patients were assessed for malnutrition using PG-SGA, NUTRISCORE, and MST. The sensitivity, specificity, and areas under the receiver operating characteristic curve were estimated for NUTRISCORE and MST using PG-SGA as a reference.Results: A total of 1000 cancer patients were included. The mean age was 55.9 (19 to 92 years), and 47.5% were male. 450 patients (45.0%) had PG-SGA B and C, 29 patients (2.9%) had a NUTRISCORE ≥ 5, and 367 patients (36.7%) had MST ≥ 2. With PG-SGA as a reference method, the sensitivity, specificity, and area under the curve values of the NUTRISCORE was 6.2 %, 99.8%, and 0.53, respectively. The sensitivity, specificity, and area under the curve values of the MST were 50.9%, 74.9%, and 0.63, respectively. The kappa index between NUTRISCORE and the PG-SGA were 0.066 and 0.262 between MST and the PG-SGA (P < 0.05).Conclusions: NUTRISCORE was found a higher specificity and lower sensitivity compared with MST using PG-SGA as a reference method in cancer patients in China. Further studies are needed.

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“…Nutritional and immune status has been proven to correlate with therapeutic effects and long-term prognosis in various tumors, including osteosarcoma. 5,6,20,47 A series of nutrition-and immune-based indices or scoring systems were developed and utilized as prognostic predictors, 6,[48][49][50][51] with the CONUT score being the most commonly used one among them. As an immune-nutritional marker, CONUT score has included the information of serum levels of albumin, cholesterol, and TLC.…”

Section: Discussionmentioning

confidence: 99%

<p>CONUT Score or/and Peripheral Blood CD4+/CD8+ Ratio-Based Web Dynamic Nomograms to Predict the Individualized Survival of Patients with Advanced Osteosarcoma</p>

Yang

Wang

et al. 2020

CMAR

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Background: Nutritional and immune status is paramount for the overall survival (OS) of patients with advanced osteosarcoma. Comprehensive prognostic predictors based on the two indices are scarce. This study aimed to construct and validate individualized web dynamic nomograms based on CONUT score or/and peripheral blood CD4+/CD8+ ratio for OS in patients with advanced osteosarcoma. Materials and Methods: The clinical data of 376 advanced osteosarcoma patients from January 2000 to December 2019 were retrospectively collected. Data from the 301 patients (diagnosed in the first 15 years) were used as the development set and data from the remaining 75 patients were assigned as the validation set. Multivariate Cox regression analyses were conducted and three prediction models were constructed, namely, CD4 +/CD8+ ratio univariate model (model 1), CONUT score univariate model (model 2), and CD4+/CD8+ ratio plus CONUT score (model 3). These models were visualized by conventional nomograms and individualized web dynamic nomograms, and their performances were further evaluated by C-index, calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA), respectively. Results: In multivariate Cox analysis, age, metastasis, ALP, CD4+/CD8+ ratio, chemotherapy, and CONUT score were identified as independent prognostic factors for OS. The calibration curves of the three models all showed good agreement between the actual observation and nomogram prediction for 1-year overall survival. In the development set, the C-index and area under the curve (AUC) of model 3 (0.837, 0.848) were higher than that of model 1 (0.765, 0.773) and model 2 (0.712, 0.749). Similar trends were observed in the validation set. The net benefits of model 3 were better than the other two models within the threshold probability of 36-80% in DCA. Conclusion: CONUT score and peripheral CD4+/CD8+ ratio are easily available, reliable, and economical prognostic predictors for survival prediction and stratification in patients with advanced osteosarcoma, but the two predictors combined can establish a better prognosis prediction model.

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Nutritional status and postoperative outcomes in patients with gastrointestinal cancer in Vietnam: a retrospective cohort study

Cited by 30 publications

References 25 publications

Nutritional Intervention Improves Nutrition Outcomes in Stomach and Colon Cancer Patients Receiving Chemotherapy: Finding from a Quasi-Experiment in Vietnam

Nutritional Intervention Improves Nutrition Outcomes in Stomach and Colon Cancer Patients Receiving Chemotherapy: Finding from a Quasi-Experiment in Vietnam

Validation of the Efficacy of the NUTRISCORE for Nutritional Screening of Cancer Patients in China

<p>CONUT Score or/and Peripheral Blood CD4+/CD8+ Ratio-Based Web Dynamic Nomograms to Predict the Individualized Survival of Patients with Advanced Osteosarcoma</p>

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