Nutritional status and body composition assessment in patients with a new diagnosis of advanced solid tumour: Exploratory comparison of computed tomography and bioelectrical impedance analysis

Casirati, Amanda; Vandoni, G.; Valle, S. Della; Greco, G; Platania, Marco; Colatruglio, S.; Lalli, Luca; Gavazzi, Cecilia

doi:10.1016/j.clnu.2020.08.009

Cited by 14 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is worth mentioning that the high incidence of sarcopenia in patients with PCa (30–80%) [ 29 , 33 ] is observed in the clinical setting. It was suggested by Casirati et al [ 34 ] that the prevalence of data on malnutrition expressed as weight loss is more in agreement with those of sarcopenia recognized using CT. This is consistent with our observation and obtained results in terms of TM and SMI changes.…”

Section: Discussionmentioning

confidence: 65%

Androgen Deprivation Therapy for Prostate Cancer Influences Body Composition Increasing Risk of Sarcopenia

et al. 2023

View full text Add to dashboard Cite

Computed tomography (CT) scans used in treatment response assessment in prostate cancer (PCa) patients are a useful tool for nutritional status evaluation. The aim of this study was to assess the nutritional status, including sarcopenia development based on CT scans, in PCa patients and its association with progression-free survival (PFS). Sixty-four PCa patients were included (group 1: 34 patients undergoing androgen deprivation therapy (ADT) with docetaxel due to newly diagnosed, hormone-sensitive, metastatic PCa and group 2: 30 patients with castration-resistant metastatic PCa continuing ADT therapy with enzalutamide or abiraterone acetate). Nutritional status was evaluated with anthropometrical parameters, Nutritional Risk Score (NRS), and CT scans at the L3 vertebrae. Survival analyses were performed. According to NRS, nutritional status was significantly related to PFS. In both groups, there was a significant reduction in muscle tissue (total muscle tissue and skeletal muscle index). A significant increase in the distribution of adipose tissue (subcutaneous fat, visceral fat, subcutaneous adipose tissue index, and visceral adipose tissue index) in group one was observed. Sarcopenia was diagnosed in patients but with no influence on PFS. Significant reduction in muscle mass and increase in fat mass was observed in patients treated for PCa with no impact on PFS. The NRS was related to PFS in PCa patients and associated with body composition, assessed by CT after the castration therapy. Long-term castration combined with abiraterone therapy with prednisone or enzalutamide significantly influenced muscle tissue and may lead to sarcopenia development.

show abstract

Section: Discussionmentioning

confidence: 65%

Androgen Deprivation Therapy for Prostate Cancer Influences Body Composition Increasing Risk of Sarcopenia

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Bioelectric impedance analysis (BIA) is also a novel method, often used. A definitive, randomized comparison of the two methods has not been done, but exploratory comparisons suggest that image-based method is more accurate [29,30]. Although the Global Leadership Initiative on Malnutrition has recently proposed a consensus on the criteria to diagnose malnutrition both for inpatients and for outpatients [31], the worldwide validity of these criteria is still unconfirmed.…”

Section: Detecting Malnutrition From the Very Beginning Of Cancer Care: Who Starts Well Is Half The Battlementioning

confidence: 99%

The Clinical Value of Nutritional Care before and during Active Cancer Treatment

Aprile¹,

Basile²,

Giaretta³

et al. 2021

Nutrients

View full text Add to dashboard Cite

Malnutrition and muscle wasting are frequently reported in cancer patients, either linked to the tumor itself or caused by oncologic therapies. Understanding the value of nutritional care during cancer treatment remains crucial. In fact, cancer-associated sarcopenia plays a key role in determining higher rates of morbidity, mortality, treatment-induced toxicities, prolonged hospitalizations and reduced adherence to anticancer treatment, worsening quality of life and survival. Planning baseline screening to intercept nutritional troubles earlier, organizing timely reassessments, and providing adequate counselling and dietary support, healthcare professional may positively interfere with this process and improve patients’ overall outcomes during the whole disease course. Several screening tools have been proposed for this purpose. Nutritional Risk Screening (NRS), Mini Nutritional Assessment (MNA), Patient Generated Subjective Global Assessment (PG-SGA) are the most common studied. Interestingly, second-level tools including skeletal muscle index (SMI) and bioelectric impedance analysis (BIA) provide a more precise assessment of body composition, even if they are more complex. However, nutritional assessment is not currently used in clinical practice and procedures must be standardized in order to improve the efficacy of standard chemotherapy, targeted agents or even checkpoint inhibitors that is potentially linked with the patients’ nutritional status. In the present review, we will discuss about malnutrition and the importance of an early nutritional assessment during chemotherapy and treatment with novel checkpoint inhibitors, in order to prevent treatment-induced toxicities and to improve survival outcomes.

show abstract

“…Bioelectrical impedance spectroscopy (BIS) is a technology that is widely used for the assessment of body composition. The method is based on the measurement of the electrical resistance of the body or a body region that can be quantitatively related to the amount of water in the tissues [ 14 , 15 ]. The paper [ 16 ] traces the evolution of the BIS technique since its inception and presents the current state of the art, with particular emphasis on utility in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Bioelectrical Impedance Spectrum for Elbow Stiffness Based on Hilbert–Huang Transform

Gao

Zhang

et al. 2022

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

With the advent of posttraumatic elbow rehabilitation, prevention of elbow stiffness has become a key part of the development of sports medicine. In order to clarify the time point of joint movement after internal fixation to the elbow and to provide a mechanical model for individualized diagnosis. This paper uses electromagnetic wave detection technology to quickly detect the bioelectrical impedance signal of the patient's lesion location, then passes the message to the upper control system for processing, summarizes the improved Hilbert–Huang transform to deep learning, and deep learning algorithms and computer technology are used to mine the bioelectrical impedance signal of the elbow joint. The simulation and human experiment results show that bioelectrical impedance signals can clarify the pathogenesis of elbow joint stiffness and the relationship between rehabilitation treatment time and duration. It has the advantages of low cost, high fitting accuracy, strong robustness, and noninvasiveness.

show abstract

Nutritional status and body composition assessment in patients with a new diagnosis of advanced solid tumour: Exploratory comparison of computed tomography and bioelectrical impedance analysis

Cited by 14 publications

References 24 publications

Androgen Deprivation Therapy for Prostate Cancer Influences Body Composition Increasing Risk of Sarcopenia

Androgen Deprivation Therapy for Prostate Cancer Influences Body Composition Increasing Risk of Sarcopenia

The Clinical Value of Nutritional Care before and during Active Cancer Treatment

Analysis of Bioelectrical Impedance Spectrum for Elbow Stiffness Based on Hilbert–Huang Transform

Contact Info

Product

Resources

About