Nutritional Status After Intestinal Transplantation in Children

Encinas, José Luis; Luis, A. L.; Ávila, Lívia Keismanas de; Hernandez, Francisco A.; Sarriá, J.; Gámez, M; Murcia, J; Leal, L.; López‐Santamaría, Manuel; Tovar, Juan A.

doi:10.1055/s-2006-924735

Cited by 17 publications

(8 citation statements)

References 12 publications

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“…We have reported that, in our patients, hyperphagia often compensated for suboptimal energy absorption and steatorrhoea, thus resulting in normal growth (13). Few studies have described the capacity of absorption of the allograft (14)(15)(16)(17)(18). Our aim here was to analyze more precisely the net intestinal absorption rates in children early after ITx at the time of PN weaning.…”

Section: Introductionmentioning

confidence: 97%

Intestinal absorption rate in children after small intestinal transplantation

Ordonez

Barbot-Trystram²,

Lacaille³

et al. 2013

The American Journal of Clinical Nutrition

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Section: Introductionmentioning

confidence: 97%

Intestinal absorption rate in children after small intestinal transplantation

Ordonez

Barbot-Trystram²,

Lacaille³

et al. 2013

The American Journal of Clinical Nutrition

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“…Important deficiencies are seen before transplantation in serum albumin and prealbumin levels in patients with intestinal failure, and these deficiencies improve significantly after intestinal transplantation. Nutritional parameters in blood were evaluated as markers of graft function . Mostly normal prealbumin and normal albumin and vitamin B12 levels suggested a generally efficient absorption.…”

Section: Discussionmentioning

confidence: 99%

Long‐term outcomes of living‐related small intestinal transplantation in children: A single‐center experience

Aroz

Tzvetanov

Hetterman

et al. 2017

Pediatric Transplantation

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Pediatric patients with irreversible intestinal failure present a significant challenge to meet the nutritional needs that promote growth. From 2002 to 2013, 13 living-related small intestinal transplantations were performed in 10 children, with a median age of 18 months. Grafts included isolated living-related intestinal transplantation (n=7), and living-related liver and small intestine (n=6). The immunosuppression protocol consisted of induction with thymoglobulin and maintenance therapy with tacrolimus and steroids. Seven of 10 children are currently alive with a functioning graft and good quality of life. Six of the seven children who are alive have a follow-up longer than 10 years. The average time to initiation of oral diet was 32 days (range, 13-202 days). The median day for ileostomy takedown was 77 (range, 18-224 days). Seven children are on an oral diet, and one of them is on supplements at night through a g-tube. We observed an improvement in growth during the first 3 years post-transplant and progressive weight gain throughout the first year post-transplantation. Growth catch-up and weight gain plateaued after these time periods. We concluded that living donor intestinal transplantation potentially offers a feasible, alternative strategy for long-term treatment of irreversible intestinal failure in children.

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“…Other areas of investigation of considerable importance to the clinician caring for intestinal transplant recipients include assessment of outcomes (neurodevelopmental, quality of life, growth, and nutrition) [47][48][49][50].…”

Section: Additional Areas Of Investigationmentioning

confidence: 99%

Current perspectives on pediatric intestinal transplantation

Mazariegos

Squires²,

Sindhi³

2009

Curr Gastroenterol Rep

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Irreversible intestinal failure in children is predominantly caused by surgical conditions such as volvulus, necrotizing enterocolitis, and gastroschisis. Functional intestinal failure from motility disorders such as intestinal pseudo-obstruction or enterocyte dysfunction with microvillus inclusion disease also may require intestine replacement. Approved indications for intestinal transplantation include liver dysfunction, loss of major venous access, frequent central line-related sepsis, and recurrent episodes of severe dehydration despite intravenous fluid management. Surgical options include transplantation of the isolated intestine, combined liver-intestine transplantation, or multivisceral transplantation of the stomach, duodenum, pancreas, and small bowel (with or without the liver). Immunosuppression for intestinal transplantation is based on tacrolimus therapy, often with induction immunosuppression using antilymphocyte antibodies (eg, antithymocyte antibody and alemtuzumab). Experience at centers of excellence demonstrates 1- and 5-year patient survival rates of 95% and 77%, respectively, with ongoing investigations focusing on lowering long-term causes of graft loss such as chronic rejection.

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Nutritional Status After Intestinal Transplantation in Children

Cited by 17 publications

References 12 publications

Intestinal absorption rate in children after small intestinal transplantation

Intestinal absorption rate in children after small intestinal transplantation

Long‐term outcomes of living‐related small intestinal transplantation in children: A single‐center experience

Current perspectives on pediatric intestinal transplantation

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