Nutritional Risk and Mortality at One Year for Elderly Patients Hospitalized with Nonvalvular Atrial Fibrillation. NONAVASC Registry

Miquélez, A. Arenas; Calleja, Marisol; Gullón, Alejandra; Reino, Antonio Pose; Formiga, Francesç; Camafort, Miguel; Rodrigo, José; Mostaza, José María; Fernández, Carmen Suárez; Díez-Manglan, J

doi:10.1007/s12603-020-1418-0

Cited by 3 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Herein, we found that malnutrition is an independent risk factor for all‐cause death of elderly patients with atrial fibrillation, which is consistent with previous findings in recent years (Arenas Miquélez et al., 2020 ; Cheng et al., 2019 ; Díez‐Manglano & Clemente‐Sarasa, 2019 ). However, these studies used control nutritional status score (CONUT), prognostic nutritional index (PNI), and geriatric nutritional risk index (GNRI) as nutrition assessment tools, which require the results of blood routine, Alb, blood lipid level, and other laboratory indicators and the height and weight measurements; hence, these tools are relatively inconvenient.…”

Section: Discussionsupporting

confidence: 93%

Effect of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation: A retrospective cohort study

Zhang,

Sun,

Ding

et al. 2024

Noninvasive Electrocardiol

View full text Add to dashboard Cite

ObjectiveTo explore the influence of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation.MethodsThis retrospective observational cohort study included 196 patients, 75–102‐years‐old, with nonvalvular atrial fibrillation, hospitalized in our hospital. The nutritional status was assessed using Mini‐Nutritional Assessment—Short Form (MNA‐SF). Patients with MNA‐SF scores of 0–11 and 12–14 were included in the malnutrition and nonmalnutrition groups, respectively.ResultsThe average age of the malnutrition group was higher than that of the nonmalnutrition group, and the levels of body mass index (BMI), hemoglobin (HGB), and albumin (ALB) were significantly lower than those of the nonmalnutrition group, with statistical significance (p < .05). The incidence of all‐cause death in the malnutrition group was higher than that in the nonmalnutrition group (p = .007). Kaplan–Meier curve indicated that malnutrition patients have a higher risk of all‐cause death (log‐rank test, p = .001) and major bleeding events (p = .017). Multivariate Cox proportional hazard regression analysis corrected for confounders showed that malnutrition was an independent risk factor of all‐cause death (HR = 1.780, 95%CI:1.039–3.050, p = .036). The malnutrition group had a significantly high incidence of major bleeding than the nonmalnutrition group (p = .026), and there was no significant difference in the proportion of anticoagulation therapy (p = .082) and the incidence of ischemic stroke/systemic embolism (p = .310) between the two groups.ConclusionsMalnutrition is an independent risk factor of all‐cause death in elderly patients with atrial fibrillation. The incidence of major bleeding in malnourished elderly patients with atrial fibrillation is high, and the benefit of anticoagulation therapy is not obvious.

show abstract

Section: Discussionsupporting

confidence: 93%

Effect of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation: A retrospective cohort study

Zhang,

Sun,

Ding

et al. 2024

Noninvasive Electrocardiol

View full text Add to dashboard Cite

show abstract

“…Malnutrition is a common status in patients with chronic diseases, especially in low- and middle- income countries. More than a third of AF patients have a moderate to high risk of malnutrition [ 6 ]. Nutritional deficiencies may also be a driver of disease progression as part of a vicious cycle associated with chronic systematic inflammation, neurohumoral activation and cachexia [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among theses assessment tools, the prognostic nutritional index (PNI) and geriatric nutritional risk index (GNRI) have been widely used for screening malnutrition in clinical practice. Malnutrition determined by these scoring methods is an independent predictor of increased mortality in AF patients [ 6 , 8 ]. However, the predictive value of PNI and GNRI for LAT in patients with VAF remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of nutritional indices for left atrial thrombus in patients with valvular atrial fibrillation

Zhou,

Liang,

et al. 2023

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background The prognostic nutritional index (PNI) and geriatric nutritional risk index (GNRI) are well known indicators for adverse outcomes in various diseases, but there is no evidence on their association with the risk of left atrial thrombus (LAT) in patients with valvular atrial fibrillation (VAF). Methods A comparative cross-sectional analytical study was conducted on 433 VAF patients. Demographics, clinical characteristics and echocardiographic data were collected and analyzed. Patients were grouped by the presence of LAT detected by transesophageal echocardiography. Results LAT were identified in 142 patients (32.79%). The restricted cubic splines showed an L-shaped relationship between PNI and LAT. The dose-response curve flattened out near the horizontal line with OR = 1 at the level of 49.63, indicating the risk of LAT did not decrease if PNI was greater than 49.63. GNRI was negative with the risk of LAT and tended to be protective when greater than 106.78. The best cut-off values of PNI and GNRI calculated by receiver operating characteristics curve to predict LAT were 46.4 (area under these curve [AUC]: 0.600, 95% confidence interval [CI]:0.541–0.658, P = 0.001) and 105.7 (AUC: 0.629, 95% CI:0.574–0.684, P<0.001), respectively. Multivariable logistic regression analysis showed that PNI ≤ 46.4 (odds ratio: 2.457, 95% CI:1.333–4.526, P = 0.004) and GNRI ≤ 105.7 (odds ratio: 2.113, 95% CI:1.076–4.149, P = 0.030) were independent predictors of LAT, respectively. Conclusions Lower nutritional indices (GNRI and PNI) were associated with increased risk for LAT in patients with VAF.

show abstract

Negative Association of GNRI with All-Cause Mortality in Chinese Atrial Fibrillation Patients: A Multicenter Retrospective Cohort Study

Dong,

Lan,

You

et al. 2024

Gerontology

View full text Add to dashboard Cite

Introduction: Malnutrition is common in older atrial fibrillation (AF) patients and results in poor clinical outcomes. The Geriatric Nutritional Risk Index (GNRI) is a straightforward method for evaluating nutritional health. However, its prognostic value in AF patients is unclear. This research focused on examining the correlation between GNRI and overall mortality in Chinese individuals with AF. Methods: We performed a multicenter retrospective study at four Chinese hospitals involving patients diagnosed with AF between January 2019 and August 2023. Using GNRI, nutritional status was evaluated, classifying patients into three categories. Multivariable logistic regression and restricted cubic spline analysis assess the relationship between GNRI and mortality, with exploratory subgroup analyses investigating potential effect modifiers. Results: The study included 4,878 AF patients with a median follow-up of 19 months. The mean age was 71 (63-78), and the mean GNRI was 102 (95-108). Malnutrition was identified in 1,776 patients (36.41%). During the study, 419 (8.59%) deaths occurred. After controlling for confounders, moderate to severe malnutrition was linked to an increased risk of all-cause mortality compared to no malnutrition (OR 1.50, 95% CI, 1.17–1.94). The relationship between GNRI and mortality risk was approximately linear, with consistent associations across subgroups. Conclusion: Malnutrition, as assessed by GNRI, is prevalent among Chinese AF patients and is independently linked to higher all-cause mortality risk.

show abstract

Nutritional Risk and Mortality at One Year for Elderly Patients Hospitalized with Nonvalvular Atrial Fibrillation. NONAVASC Registry

Cited by 3 publications

References 33 publications

Effect of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation: A retrospective cohort study

Effect of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation: A retrospective cohort study

Predictive value of nutritional indices for left atrial thrombus in patients with valvular atrial fibrillation

Negative Association of GNRI with All-Cause Mortality in Chinese Atrial Fibrillation Patients: A Multicenter Retrospective Cohort Study

Contact Info

Product

Resources

About