Nutritional Rickets Revisited

Biswas, Akhil Chandra; Molla, M A Maleque; Ljemba, J C; Moslem, Khalid Al

doi:10.5144/0256-4947.2003.328

Cited by 1 publication

(2 citation statements)

References 15 publications

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“…All mothers were having symptoms of fatigue, back pain, or other features suggestive of osteomalacia like tingling, tetany, and convulsions. Now there have been many reports suggesting that the rickets seen in the Middle East and other countries is mainly due to maternal vitamin D deficiency [1][2][3][4][5][6][7][8][9][10], but due to the trans-placental calcium pump, the effect does not manifest except sometime after birth and even longer after that with delayed walking or delayed dentition and during this period serious complications like hypocalcemic convulsions, cardiomyopathy, anemia, and myelofibrosis in addition to many infections and others are likely to be a presenting feature. The breastfed infant from an already vitamin D-deficient mother will obviously be vitamin D-deficient manifesting as congenital rickets at birth .…”

Section: Congenital Rickets Due To Maternal Osteomalaciamentioning

confidence: 99%

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The Return of Congenital Rickets, Are We Missing Occult Cases?

Elidrissy

2016

Calcif Tissue Int

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Congenital rickets is the term given to fetus born with clinical features of rickets, but those born with biochemical evidence of rickets without obvious clinical features still can be considered occult congenital rickets. Some of the affected babies with this disease have the intrauterine rachitic environment, but a calcium trans-placental pump prevents the fetus from having clinical features of rickets. They may present with hypocalcemia few days after birth or later with more florid features of rickets. Congenital rickets cases born with florid features reported over the last 40 years are few and can be divided into two groups. The first due to severe maternal osteomalacia in which their bones were so decalcified to have enough calcium to be pumped to their fetus. Another group in which newborn babies were hypocalcemic due to other maternal diseases as malabsorption, celiac disease, pre-eclampsia, and prematurity. All inherited rickets cases per se, or as part of other syndromes can be considered congenital rickets. Most cases seen in our region are due to maternal vitamin D deficiency with symptoms becoming obvious when the infants are breastfed, or may present with hypocalcemic convulsions or craniotabes. This is a review of congenital rickets with the aim of shedding light on this potentially acute disease that needs more attention and awareness in the neonatal period to avoid rare serious complications as cardiomyopathy or myelofibrosis and the complications of hypocalcemic convulsions. Congenital rickets cases seen simulate a tip of an ice-burg and its prevention is an important issue, especially with the tremendous urbanization with tall buildings living in sun-deprived flats as the commonest type of residence leading to the increasing incidence of maternal osteomalacia and rickets.

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Section: Congenital Rickets Due To Maternal Osteomalaciamentioning

confidence: 99%

“…Although rickets is still reported from different sunny countries and mostly among immigrants in temperate countries, infants born with clinical features of congenital rickets at birth are rare [1][2][3][4][5][6][7][8]. Literature was reviewed to highlight the factors associated with congenital rickets in the past and present.…”

Section: Introductionmentioning

confidence: 99%

The Return of Congenital Rickets, Are We Missing Occult Cases?

Elidrissy

2016

Calcif Tissue Int

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Nutritional Rickets Revisited

Cited by 1 publication

References 15 publications

The Return of Congenital Rickets, Are We Missing Occult Cases?

The Return of Congenital Rickets, Are We Missing Occult Cases?

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