Nutritional regulation of immunosenescence for heart health

Watson, Ronald R.; Zibadi, Sherma; Vazquez, Randy; Larson, Douglas F.

doi:10.1016/j.jnutbio.2004.10.001

Cited by 9 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This explains why Th2 cell acting as humoral immunity accounted for learning and memory deficiencies in APP/PS1 mice. There were many studies reported aging led to increased Th1 and Th2 cell numbers and a decreased Th2/Th1 ratio [ 47 , 48 ], while SAMP8 mice show the classic characteristic of AD due to aging. These indicated that the overload of Aβ peptide caused the enhanced Th2 cell immunity in APP/PS1 mice induced by APP/PS1 transgene and Th1 cell in SAMP8 mice induced by aging.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine immunomodulation network dysfunction in SAMP8 mice and PrP-hAβPPswe/PS1ΔE9 mice: potential mechanism underlying cognitive impairment

Wang¹,

Cheng²,

Zhang³

et al. 2016

Oncotarget

View full text Add to dashboard Cite

Senescence-accelerated mouse prone 8 strain (SAMP8) and PrP-hAβPPswe/PS1ΔE9 (APP/PS1) mice are classic animal models of sporadic Alzheimer's disease and familial AD respectively. Our study showed that object recognition memory, spatial learning and memory, active and passive avoidance were deteriorated and neuroendocrine immunomodulation (NIM) network was imbalance in SAMP8 and APP/PS1 mice. SAMP8 and APP/PS1 mice had their own specific phenotype of cognition, neuroendocrine, immune and NIM molecular network. The endocrine hormone corticosterone, luteinizing hormone and follicle-stimulating hormone, chemotactic factor monocyte chemotactic protein-1, macrophage inflammatory protein-1β, regulated upon activation normal T cell expressed and secreted factor and eotaxin, pro-inflammatory factor interleukin-23, and the Th1 cell acting as cell immunity accounted for cognitive deficiencies in SAMP8 mice, while adrenocorticotropic hormone and gonadotropin-releasing hormone, colony stimulating factor granulocyte colony stimulating factor, and Th2 cell acting as humoral immunity in APP/PS1 mice. On the pathway level, chemokine signaling and T cell receptor signaling pathway played the key role in cognition impairments of two models, while cytokine-cytokine receptor interaction and natural killer cell mediated cytotoxicity were more important in cognitive deterioration of SAMP8 mice than APP/PS1 mice. This mechanisms of NIM network underlying cognitive impairment is significant for further understanding the pathogenesis of AD and can provide useful information for development of AD therapeutic drug.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuroendocrine immunomodulation network dysfunction in SAMP8 mice and PrP-hAβPPswe/PS1ΔE9 mice: potential mechanism underlying cognitive impairment

Wang¹,

Cheng²,

Zhang³

et al. 2016

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Immunosenescence also plays a role in regulatory impairment of fibroblasts and consequently, remodeled cardiac morphology through upregulation of cytokines [114]. Reduced lymphocyte counts were found to be characteristic of advanced heart failure.…”

Section: Inflammaging In Cardiovascular Disease (Cvd)mentioning

confidence: 99%

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Zuo

Stetskiv

et al. 2019

IJMS

309

201

View full text Add to dashboard Cite

It has been proposed that a chronic state of inflammation correlated with aging known as inflammaging, is implicated in multiple disease states commonly observed in the elderly population. Inflammaging is associated with over-abundance of reactive oxygen species in the cell, which can lead to oxidation and damage of cellular components, increased inflammation, and activation of cell death pathways. This review focuses on inflammaging and its contribution to various age-related diseases such as cardiovascular disease, cancer, neurodegenerative diseases, chronic obstructive pulmonary disease, diabetes, and rheumatoid arthritis. Recently published mechanistic details of the roles of reactive oxygen species in inflammaging and various diseases will also be discussed. Advancements in potential treatments to ameliorate inflammaging, oxidative stress, and consequently, reduce the morbidity of multiple disease states will be explored.

show abstract

“…Christon (2003) and Denke (2006) suggest that whatever CLAs do (or not do) in this regard, omega-3 fatty acids are likely to be superior in efficacy. Watson et al (2005), by contrast, posits that both agents will help prevent heart I aging through redttcing the levels of inflammatory substances caused by immunological overreaction.…”

Section: Conjugated Linoleic Acids Cardiovascular Health Atherosclementioning

confidence: 99%

Turning Meat, Poultry, Eggs, and Dairy Products Into Nutraceuticals Through Increasing Their Conjugated Linoleic Acid Levels, Part One: Reviewing the Literature of Benefits Claimed for Conjugated Linoleic Acids in Human Health

Stankus

2008

Journal of Agricultural & Food Information

View full text Add to dashboard Cite

In the first of ihis iwo-pari series of articles, the débale in Ihc clinical lilcralure over the reality (ir extent ot" particular positive health benefits of a pulative nutraeeutieul, eonjugatecl linoleic acids (CLAs). in human subjeets will be reviewed. In the second artiele, the means by whieh animal scientists and farmers-resptiniling as niueh to annual sales in the hundreds of millions of dollars in health food slores of seed oil capsules rieh in CLAs, as opposed to any eonclusive elinical scienee-are aggressively pursuing ways lo feed livestiKk that would naturally increase the concentration of CLAs per conventional consumer dietary portions, essentially allowing meat, eggs, fluid milk and the processed fcxKls derived from them to be marketed us functional foods. In both installments in this series, the core journals covering developments in CLA related research aie identified for agricultural and ftKxl seienee librarians.

show abstract

Nutritional regulation of immunosenescence for heart health

Cited by 9 publications

References 11 publications

Neuroendocrine immunomodulation network dysfunction in SAMP8 mice and PrP-hAβPPswe/PS1ΔE9 mice: potential mechanism underlying cognitive impairment

Neuroendocrine immunomodulation network dysfunction in SAMP8 mice and PrP-hAβPPswe/PS1ΔE9 mice: potential mechanism underlying cognitive impairment

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Turning Meat, Poultry, Eggs, and Dairy Products Into Nutraceuticals Through Increasing Their Conjugated Linoleic Acid Levels, Part One: Reviewing the Literature of Benefits Claimed for Conjugated Linoleic Acids in Human Health

Contact Info

Product

Resources

About