Nutritional Regulation of Human Brown Adipose Tissue

Suchacki, Karla J; Stimson, Roland H

doi:10.3390/nu13061748

Cited by 26 publications

(20 citation statements)

References 190 publications

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“…[41] In line with our results, some authors have suggested that phenolic compounds, which are present in high amounts in EVOO, may be responsible for this browning effect via PGC-1𝛼 activation. [42,43] Nrf2 is a transcription factor that plays a critical role in mitochondrial biogenesis and controls the capacity for adipose tissue expansion. [44] Nrf2 also protects cells against oxidative stress and has a potent anti-inflammatory effect.…”

Section: Discussionmentioning

confidence: 99%

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Differential Immunometabolic Effects of High‐Fat Diets Containing Coconut, Sunflower, and Extra Virgin Olive Oils in Female Mice

Rodríguez-García

Sánchez-Quesada

Algarra

et al. 2022

Molecular Nutrition Food Res

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Scope: To compare the effects of three high-fat diets (HFDs) based on coconut, sunflower, or extra virgin olive oils (EVOOs) on adipose tissue, metabolism, and inflammation. Methods and Results: Mice are fed for 16 weeks on their respective HFD. HFD based on coconut oil produces significantly lower body weight than EVOO-or sunflower oil-based HFDs. Furthermore, the coconut oil HFD leads to metabolic disturbances such as reduction of circulating leptin and adiponectin concentrations, hypertriglyceridemia, hepatomegaly, and liver triglyceride accumulation. Likewise, this diet produces an increase in serum pro-inflammatory cytokines (interleukin 6 [IL-6] and tumor necrosis factor-𝜶 [TNF-𝜶]). In white (WAT) and brown (BAT) adipose tissue, the HFD based on coconut oil does not cause significant changes in the expression of studied proteins related to thermogenesis (uncoupling protein 1 [UCP-1]), mitochondrial biogenesis, and browning (peroxisome proliferator-activated receptor-𝜸 coactivator 1𝜶 [PGC-1𝜶] and nuclear factor E2-related factor 2 [Nrf2]). However, the HFD based on EVOO induces upregulation of UCP-1, PGC-1𝜶, and Nrf2 expression in BAT, increases the expression of UCP-1 and PGC-1𝜶 in inguinal WAT, and enhances the expression of PGC-1𝜶 in epididymal WAT. Conclusions: An HFD based on coconut oil could reduce circulating leptin and adiponectin concentrations, increase the liver fat content, raise serum triglycerides, and promote inflammation by increasing circulating pro-inflammatory cytokines, while an EVOO-based HFD could increase thermogenic activity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Differential Immunometabolic Effects of High‐Fat Diets Containing Coconut, Sunflower, and Extra Virgin Olive Oils in Female Mice

Rodríguez-García

Sánchez-Quesada

Algarra

et al. 2022

Molecular Nutrition Food Res

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“…Cold acclimation increases the BAT’s oxidative capacity, which correlates with a reduction of shivering thermogenesis [ 94 , 98 ]. Cold adaptation in BAT is also associated with mitochondrial remodeling and vascularization for adaptive thermogenesis [ 91 ] and fatty acid oxidation through UCP1 during high metabolic demands [ 99 ].…”

Section: Cold Exposure and Activation Of Sympathetic Nervous Systemmentioning

confidence: 99%

Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues

Singh

Barrios

Dirakvand

et al. 2021

Cells

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Obesity-associated metabolic abnormalities comprise a cluster of conditions including dyslipidemia, insulin resistance, diabetes and cardiovascular diseases that has affected more than 650 million people all over the globe. Obesity results from the accumulation of white adipose tissues mainly due to the chronic imbalance of energy intake and energy expenditure. A variety of approaches to treat or prevent obesity, including lifestyle interventions, surgical weight loss procedures and pharmacological approaches to reduce energy intake and increase energy expenditure have failed to substantially decrease the prevalence of obesity. Brown adipose tissue (BAT), the primary source of thermogenesis in infants and small mammals may represent a promising therapeutic target to treat obesity by promoting energy expenditure through non-shivering thermogenesis mediated by mitochondrial uncoupling protein 1 (UCP1). Since the confirmation of functional BAT in adult humans by several groups, approximately a decade ago, and its association with a favorable metabolic phenotype, intense interest on the significance of BAT in adult human physiology and metabolic health has emerged within the scientific community to explore its therapeutic potential for the treatment of obesity and metabolic diseases. A substantially decreased BAT activity in individuals with obesity indicates a role for BAT in the setting of human obesity. On the other hand, BAT mass and its prevalence correlate with lower body mass index (BMI), decreased age and lower glucose levels, leading to a lower incidence of cardio-metabolic diseases. The increased cold exposure in adult humans with undetectable BAT was associated with decreased body fat mass and increased insulin sensitivity. A deeper understanding of the role of BAT in human metabolic health and its interrelationship with body fat distribution and deciphering proper strategies to increase energy expenditure, by either increasing functional BAT mass or inducing white adipose browning, holds the promise for possible therapeutic avenues for the treatment of obesity and associated metabolic disorders.

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“…Cold adaptation in BAT is also associated with mitochondrial remodeling and vascularization for adaptive thermogenesis [74] and fatty acid oxidation through UCP1 during high metabolic demands [82].…”

Section: Cold Exposure and Activation Of Sympathetic Nervous Systemmentioning

confidence: 99%

Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues

Singh¹,

Barrios²,

Dirakvand³

et al. 2021

Preprint

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Obesity-associated metabolic abnormalities comprise of a cluster of conditions including dyslipidemia, insulin resistance, diabetes, and cardiovascular diseases that has affected more than 650 million people all over the globe. Obesity results from accumulation of white adipose tissues mainly due to the chronic imbalance of energy intake and energy expenditure. Variety of approaches to treat or prevent obesity, including lifestyle interventions, surgical weight loss procedures and pharmacological approaches to reduce energy intake and increase energy expenditure have failed to substantially decrease the prevalence of obesity. Brown adipose tissue (BAT), the primary source of thermogenesis in infants and small mammals may represent a promising therapeutic target to treat obesity by promoting energy expenditure through non-shivering thermogenesis mediated by mitochondrial uncoupling protein 1 (UCP1). Since the confirmation of functional BAT in adult humans by several groups, approximately a decade ago and its association with a favorable metabolic phenotype, intense interest on the significance of BAT in adult human physiology and metabolic health has emerged within the scientific community to explore its therapeutic potential for the treatment of obesity and metabolic diseases. Substantially decreased BAT activity in individuals with obesity indicates a role for BAT in setting of human obesity. On the other hand, BAT mass and its prevalence has been reported to correlate with lower body mass index (BMI), decreased age and glucose levels, leading to lower incidence of cardio metabolic diseases. Increased cold exposure in adult humans with undetectable BAT was associated with decreased body fat mass and increased insulin sensitivity. Deeper understanding of the role of BAT in human metabolic health and its inter-relationship with body fat distribution and deciphering proper strategies to increase energy expenditure by either increasing functional BAT mass, or inducing white adipose browning holds the promise for possible therapeutic avenues for the treatment of obesity and associated metabolic disorders.

show abstract

Nutritional Regulation of Human Brown Adipose Tissue

Cited by 26 publications

References 190 publications

Differential Immunometabolic Effects of High‐Fat Diets Containing Coconut, Sunflower, and Extra Virgin Olive Oils in Female Mice

Differential Immunometabolic Effects of High‐Fat Diets Containing Coconut, Sunflower, and Extra Virgin Olive Oils in Female Mice

Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues

Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues

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