Nutritional Regulation of Apolipoprotein Genes: Effect of Dietary Carbohydrates and Fatty Acids

Ribeiro, Agnès; Mangeney, Marianne; Cardot, Philippe; Loriette, C; Chambaz, Jean; Rayssiguier, Yves; Béréziat, G.

doi:10.1007/978-1-4684-5904-3_49

Cited by 4 publications

(3 citation statements)

References 45 publications

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“…Since newly-synthesized fatty acids are preferentially channelled into VLDL, the lipogenic activity of the liver is a key factor in hepatic VLDL-TAG output (Gibbons, 1990;Ribiero et al 1991;Arbeeny et al 1992;Park et al 1992). Among the key enzymes that control lipogenesis, fatty acid synthase (FAS) is the most sensitive to nutrients and hormones (Boll et al 1994).…”

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confidence: 99%

Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats

et al. 1996

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Dietary supplementation with oligofructose (Om; 100 g/kg), a nodigestible oligomer of /h-fructose, decreases serum triacylglycerols in serum and VLDL of rats. In order to investigate the role of hepatic metabolism in the hypolipidaemic effect of Om, male Wistar rats were fed on a standard diet with or without 1OOg Raftilosee P d k g as OFS source for 30d. OFS feeding (1) significantly decreased triacylglycerol and phqholipid concentrations in both blood and liver, (2) increased the glycerol-3-phosphate liver content but decreased the hepatic activity of glycerol-3-phosphate acyltransferase (EC 2 -3.1. W), suggesting a decrease in acylglycerol synthesis, (3) did not affect the blood non-esterified fatty acid concentrations, but (4) reduced by 54% the capacity of isolated hepatocytes to synthesize and secrete triacylglycerols from labelled acetate; the activity of fatty acid synthase, a key lipogenic enzyme was also significantly decreased. These findings suggest that OFS decreases sennu triacylglycerols by reducing de nova fatty acid synthesis in the liver; the lower insulin level in the serum of OFS-fed rats could explain, at least partly, the metabolic effect induced by such nondigestible carbohydrates. Feeding rats on a diet supplemented with oligofructose (OFS; lWg/kg), a nondigestible but fermentable oligomer of /3-D-fructose obtained by enzymic hydrolysis of chicory (Cichorium intybus) inulin, significantly lowers serum TAG and phospholipid (PL) concentrations (Delzenne et al. 1993). This is exclusively due to a decrease in the concentration of plasma VLDL (Fiordaliso et al. 1995). The hepatic synthesis of VLDL involves the biosynthesis of both lipids and apoproteins, their assembly into nascent VLDL particles, and the secretion of mature VLDL into the circulation (Gibbons, 1990).Since newly-synthesized fatty acids are preferentially channelled into VLDL, the lipogenic activity of the liver is a key factor in hepatic VLDL-TAG output (Gibbons, 1990

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confidence: 99%

Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats

et al. 1996

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“…It has been discussed (4,5) that this impaired capability for enzyme induction does not result from a deficiency in hepatic enzyme responsiveness, but results from disturbances in the availability and/or effectiveness of key hormones, i.e., insulin, glucagon, adrenal glucocorticoids, and thyroid hormones. Regulation of rat liver apoB gene expression has also been reported to respond to endocrine signals (17)(18)(19). It appears that several proteins implicated in triglyceride synthesis and transport are less inductible by dietary fructose in adult rats than in young animals.…”

Section: Discussionmentioning

confidence: 96%

Age-Related Response to Dietary Fructose in the Rat: Discrepancy in Triglyceride and Apolipoprotein B Synthesis as a Possible Mechanism for Fatty Liver Induction in Adult Rats

Nassir¹,

Mazur²,

Felgines³

et al. 1993

Experimental Biology and Medicine

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The effects of fructose feeding on plasma and liver lipids, triglyceride secretion, and plasma apolipoprotein B and their liver mRNA level were studied in young and adult rats. We have shown that the responsiveness of adult rats to dietary fructose differs from that of young rats with regard to body parameters as well biochemical analyses. In young rats, fructose diet causes a coupled induction of liver triglyceride and apolipoprotein B synthesis via increased mRNA level. In adult rats it appears that triglyceride secretion is lower and less inducible by dietary fructose than in young rats. This insufficient export of the excess of synthesized triglycerides may cause fatty liver in adult animals. Reduced adaptation of liver lipoprotein secretion to dietary carbohydrates in adult animals may be explained by the failure to stimulate apolipoprotein B synthesis at the mRNA level in these rats.

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“…ApoC-III is a major component of triglyceriderich lipoparticles and interferes with VLDL lipolysis (27)(28)(29)(30) and uptake by cellular receptor (31)(32)(33)(34). Evidence also exists that fatty acids exert part of their lipid-lowering effects by altering the expression of various apo genes (35). As a first indication of a possible effect of pine seed oil on apo gene expression, the mRNA levels of apoA-I, apoA-II, apoC-III, and apoE were measured in the liver of supplemented rats.…”

Section: Discussionmentioning

confidence: 98%

Effects of Pinus pinaster and Pinus koraiensis seed oil supplementation on lipoprotein metabolism in the rat

Asset

Staels

Wolff

et al. 1999

Lipids

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The aim of the present study was to assess the effect of vegetal oils obtained from Pinus pinaster and P. koraiensis seeds on plasma lipoprotein levels and apolipoprotein (apo) gene expression in rats. These oils contain two particular fatty acids of the delta5-unsaturated polymethylene-interrupted fatty acid (delta5-UPIFA) family: all-cis-5,9,12-1 8:3 (pinolenic) and/or all-cis-5,11,14-20:3 (sciadonic) acids. Rats were fed for 28 d a diet containing 5% (w/w) oil supplement. Two control diets were prepared to match the fatty acid composition of P. pinaster or P. koraiensis oils with the exception of delta5-UPIFA, which were replaced by oleic acid. Pinus pinaster seed oil decreased serum triglycerides by 30% (P < 0.02), very low density lipoprotein (VLDL)-triglycerides by 40% (P < 0.01), and VLDL-cholesterol by 33% (P < 0.03). Pinus koraiensis seed oil decreased serum triglycerides by 16% [not statistically significant (ns)] and VLDL-triglycerides by 21% (ns). Gel permeation chromatography and nondenaturating polyacrylamide gel electrophoresis showed a tendency of high density lipoprotein to shift toward larger particles in pine seed oil-supplemented rats. Finally, P. pinaster seed oil treatment was associated with a small decrease of liver apoC-III (P < 0.02) but not in apoE, apoA-I, or apoA-II mRNA levels. The levels of circulating apo were not affected by pine seed oil supplementation. In conclusion, P. pinaster seed oil has a triglyceride-lowering effect in rats, an effect that is due to a reduction in circulating VLDL.

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Nutritional Regulation of Apolipoprotein Genes: Effect of Dietary Carbohydrates and Fatty Acids

Cited by 4 publications

References 45 publications

Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats

Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats

Age-Related Response to Dietary Fructose in the Rat: Discrepancy in Triglyceride and Apolipoprotein B Synthesis as a Possible Mechanism for Fatty Liver Induction in Adult Rats

Effects of Pinus pinaster and Pinus koraiensis seed oil supplementation on lipoprotein metabolism in the rat

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