Nutritional Regulation of Aging and Longevity

Moskalev, Alexey

doi:10.1007/978-3-030-83017-5_21

Cited by 3 publications

(1 citation statement)

References 168 publications

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“…Phytonutrients, such as the polyphenols apigenin, quercetin, and proanthocyanidins, have been shown to modulate and suppress many of these signaling pathways [32]. Other neuronutrients affect neuroinflammation and oxidative/nitrosative stress and/or modify neurotransmitter chemistry [33,34] Food is a complex combination of multiple nutrients and anti-nutrients, many of which have been shown to modulate inter alia gene expression and metabolic pathways [35].…”

Section: Nutrient Interactionsmentioning

confidence: 99%

Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

Badaeva

Danilov

Clayton³

et al. 2023

Nutrients

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The term neuronutrition has been proposed as part of nutritional neuroscience, studying the effects of various dietary components on behavior and cognition. Other researchers underline that neuronutrition includes the use of various nutrients and diets to prevent and treat neurological disorders. The aim of this narrative review was to explore the current understanding of the term neuronutrition as the key concept for brain health, its potential molecular targets, and perspectives of its nutritional approach to the prevention and treatment of Alzheimer’s and Parkinson’s diseases, multiple sclerosis, anxiety, depressive disorders, migraine, and chronic pain. Neuronutrition can be defined as a part of neuroscience that studies the influence of various aspects of nutrition (nutrients, diet, eating behavior, food environment, etc.) on the development of nervous disorders and includes nutrition, clinical dietetics, and neurology. There is evidence that the neuronutritional approach can influence neuroepigenetic modifications, immunological regulation, metabolic control, and behavioral patterns. The main molecular targets in neuronutrition include neuroinflammation, oxidative/nitrosative stress and mitochondrial dysfunction, gut–brain axis disturbance, and neurotransmitter imbalance. To effectively apply neuronutrition for maintaining brain health, a personalized approach is needed, which includes the adaptation of the scientific findings to the genetic, biochemical, psycho-physiological, and environmental features of each individual.

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Section: Nutrient Interactionsmentioning

confidence: 99%

Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

Badaeva

Danilov

Clayton³

et al. 2023

Nutrients

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Redox-based Disruption of Cellular Hormesis and Promotion of Degenerative Pathways: Perspectives on Aging Processes

Bevere

Cola

Santangelo

et al. 2022

The Journals of Gerontology: Series A

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The present work aims to link the redox and cell-centric theories of chronic processes in human biology, focusing on ageing. A synthetic overview of cellular redox pathways will be integrated by the concept of hormesis, which disruption leads to several physiopathological processes. The onset of age-related diseases due to the restriction of homeodynamic capacity will be herein considered in a redox fashion. Up-to-date arguments on hormetic agents, such as geroprotectors, dietary interventions, and physical exercise are refining the presented theoretical framework, integrated by insights from extracellular vesicles, microbiota, pollutants, and timing mechanisms. The broad concepts of exposome encompass the redox-based alteration of cellular hormesis for providing meaningful perspectives on redox biogerontology.

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Antioxidant and Geroprotective Properties of the Extract of Mountain Ash (<i>Sorbus aucuparia</i> L.) Fruits

Platonova,

Golubev,

Zemskaya

et al. 2023

Molekulârnaâ biologiâ

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Plant polyphenols are characterized by a wide range of biological activities, including antioxidant properties, and have a high geroprotective potential. The purpose of this work was to investigate the effect of the extract of rowan berries (Sorbus aucuparia L.) on the lifespan and stress resistance of Drosophila melanogaster with the identification of possible mechanisms of its biological activity. It has been established that the ethanol extract of S. aucuparia berries, the main components of which are rutin and cyanidin-3-rutinoside, has a pronounced antioxidant activity in vitro. At the same time, treatment with rowan berry extract increased the r-esistance of D. melanogaster males to starvation, but reduced resistance to hyperthermia. In females, the e-xtract reduced resistance to oxidative stress but increased resistance to hyperthermia. The effects of rowan berry extract on longevity depended both on its concentration and on the sex of fruit flies. In response to treatment with rowan berry extract, D. melanogaster males and females showed slight differences in the background level of expression of cellular stress response genes, including heat shock genes (hsp27, hsp68, hsp83), oxidative stress resistance genes (hif1, nrf2, sod1), circadian rhythm genes (clk, per), and the longevity gene sirt1, which may explain the differences in the observed effects.

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Nutritional Regulation of Aging and Longevity

Cited by 3 publications

References 168 publications

Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

Redox-based Disruption of Cellular Hormesis and Promotion of Degenerative Pathways: Perspectives on Aging Processes

Antioxidant and Geroprotective Properties of the Extract of Mountain Ash (<i>Sorbus aucuparia</i> L.) Fruits

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