Nutritional Profile and Inflammatory Status of Hemodialysis Patients

Faintuch, Joel; Morais, Álvaro A. C.; Silva, Maria A. T.; Vidigal, Erica J.; Costa, Rozilene A.; Lyrio, Daniele C.; Trindade, Célia Regina; Pitanga, Karoline K.

doi:10.1080/08860220600577742

Cited by 12 publications

(9 citation statements)

References 22 publications

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“…Various anthropometric variables are depressed in such individuals than the general population [29]. Similarly in the present study, patients were malnourished according to SGA.…”

Section: Discussionmentioning

confidence: 96%

Serum Zinc, Plasma Ghrelin, Leptin Levels, Selected Biochemical Parameters and Nutritional Status in Malnourished Hemodialysis Patients

Şahin

Uyanik

İnanç

et al. 2008

Biol Trace Elem Res

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This study was performed to investigate the serum zinc (Zn), plasma ghrelin, leptin levels and nutritional status, and to evaluate the potential association between malnutrition and these investigated parameters in malnourished hemodialysis (HD) patients. Fifteen malnourished HD patients, aged 42.9 +/- 2.11 years, who underwent the HD for 46.44 +/- 7.1 months and 15 healthy volunteers, aged 41.0 +/- 2.17 years, were included in this study. The nutritional status of the subjects was determined by the subjective global assessment (SGA). Anthropometric measurements were taken by bioelectrical impedance after HD. Blood samples were collected for the analysis of zinc (Zn), ghrelin, leptin, and selected blood parameters. The HD patients consumed less energy and nutrients than controls. In HD patients, body weight, body mass index (BMI) (p < 0.001), basal metabolic rate (BMR), body fat, lean body mass (LBM), serum Zn, copper (Cu) (p < 0.05), sodium (Na) (p < 0.01), glucose (p < 0.05), albumin (p < 0.01), total cholesterol (p < 0.001), and ghrelin (p < 0.05) were lower whereas body water ratio (p < 0.001), serum potassium (K) (p < 0.01), inorganic phosphorous (Pi), blood urea nitrogen, creatinine (p < 0.001), and plasma insulin (p < 0.05) levels were higher than the controls. No difference existed between HD patients and controls regarding plasma leptin levels. There were positive correlations for body weight-fasting glucose and body weight-leptin (p < 0.05), body weight-BMI and body weight-LBM (p < 0.01); body fat-leptin (p < 0.05); BMI-fasting glucose, BMI-leptin, and BMI-body fat (p < 0.05); albumin-hemoglobin and albumin-insulin (p < 0.05). Negative correlation was found for SGA score-ghrelin (p < 0.05). Malnutrition in HD patients may result from inadequate energy and nutrient intake and low Zn and ghrelin levels. Zinc supplementation to the diets of HD patients may be of value to prevent the malnutrition.

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“…Various anthropometric variables are depressed in such individuals than the general population [29]. Similarly in the present study, patients were malnourished according to SGA.…”

Section: Discussionmentioning

confidence: 96%

Serum Zinc, Plasma Ghrelin, Leptin Levels, Selected Biochemical Parameters and Nutritional Status in Malnourished Hemodialysis Patients

Şahin

Uyanik

İnanç

et al. 2008

Biol Trace Elem Res

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“…Nutritional markers such as serum albumin and low body mass index are associated with higher mortality rates in this population. 5 The ultimate goal is to ensure that adequate body fat levels are maintained. This is very important in relation to patients on hemodialysis, because at times of greater energy demand to which they are exposed (vascular access surgery, infections or even kidney transplant), the fat reserves can be used to supply the energy deficit, thereby safeguarding the patient's protein reserves.…”

Section: Introductionmentioning

confidence: 99%

Nutritional evaluation of stage 5 chronic kidney disease patients on dialysis

Piratelli

Telarolli

2012

Sao Paulo Med. J.

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CONTEXT AND OBJECTIVE: Patients with chronic kidney failure undergoing dialysis have high prevalence of protein-energy malnutrition. There is still no uniform method for assessing these patients' nutritional status. It is recommended that a set of subjective and objective methods should be applied so that an adequate nutritional diagnosis can be reached. The aim of this study was to evaluate the nutritional profile of patients undergoing hemodialysis. DESIGN AND SETTING: Cross-sectional study conducted in the Dialysis Treatment Unit, Araraquara, São Paulo, Brazil, in 2008. METHODS: Anthropometric and biochemical indicators were characterized for 48 patients who also gave responses to the modified Subjective Global Assessment questionnaire (SGAm), and possible correlations between these indicators were investigated. RESULTS: The frequency of moderate or severe malnutrition ranged from 22% to 54%, according to the parameter used. Regarding the patients' conformity with the ideal weight, 29% of them weighed less than 75% of the ideal, and thus were classified as having moderate or severe malnutrition. The most significant correlations were observed between body mass index (BMI) and the idealness of triceps skinfold (TSF), upper arm circumference (UAC) and upper arm muscle circumference (UAMC); and between SGAm and the idealness of UAC and UAMC. CONCLUSION: The frequency of malnutrition showed great variability among the patients, according to the evaluation criterion chosen. Routine nutritional monitoring and validation of methods for assessing body composition among such patients are extremely important for diagnosing malnutrition early on, thus preventing complications and reducing the morbidity and mortality rates in this population.RESUMO CONTEXTO E OBJETIVO: Portadores de insuficiência renal crônica em diálise apresentam alta prevalência de desnutrição proteico-energética. Não existe ainda um método uniforme para avaliar o estado nutricional desses pacientes. Recomenda-se a aplicação de um conjunto de métodos subjetivos e objetivos para se chegar aos diagnósticos nutricionais adequados. O objetivo deste estudo é traçar o perfil nutricional de pacientes submetidos a hemodiálise. TIPO DE ESTUDO E LOCAL: Estudo transversal descritivo realizado na Unidade de Tratamento Dialítico de Araraquara, São Paulo, Brasil, em 2008. MÉTODOS: 48 pacientes tiveram seus indicadores antropométricos e bioquímicos caracterizados, sendo também submetidos ao questionário Avaliação Global Subjetiva modificada (SGAm), verificando-se possí-veis correlações entre esses indicadores. RESULTADOS: A frequência de desnutrição moderada e grave variou de 22% a 54%, de acordo com o parâmetro utilizado. Com relação à adequação do peso ideal, 29% da amostra estavam com porcentagem de adequação abaixo do percentil 75, classificados como portadores de desnutrição moderada e grave. As correlações mais significativas foram observadas entre índice de massa corporal (IMC) e adequações de prega triciptal (PCT), circunferência do braço (CB) e circ...

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“…Diminished phase angle has been characterized as a marker of overhydration and arterial stiffness in hemodialysis patients, thus predicting mortality [34,35]. Again, reduced phase angle has been described as a marker of obesity and metabolic syndrome in women [36].…”

Section: Discussionmentioning

confidence: 99%

Is Intake of Vitamin D and Calcium Important for Cardiovascular Health in Elderly Obese Patients?

et al. 2012

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There is compelling evidence that bariatric weight loss reduces cardiovascular complications; however, these still tend to be the most common cause of late death after surgical intervention. In a prospective cohort study, correlations of dietary nutrients with indexes of vascular health were sought, with emphasis on vitamin D and calcium. Clinically stable obese outpatient subjects (>60 years old, N = 44) were interviewed about dietary macro and micronutrients. Nutritional assessment targeted anthropometric and bioimpedance analysis (BIA), hematologic counts, lipid profile, glucose homeostasis, and inflammatory markers. Carotid intima-media thickness (IMT) and brachial flow-mediated dilation (FMD), along with related vascular measurements, were documented, and results were correlated by uni- and multivariate analysis, corrected for known risk factors. IMT, FMD, and also brachial basal flow were positively influenced by vitamin D (P < 0.001). Calcium appeared beneficial for brachial basal flow only (P = 0.010). No association with IMT occurred, and a negative result for FMD was elicited. Also, vitamins A and B12 were advantageous for FMD, whereas iron was deleterious for IMT. Intake of many micronutrients including calcium and vitamin D did not meet recommendations. Vitamin D displayed a beneficial profile regarding vascular health, and more attention to this nutrient should be given, especially concerning obese patients with cardiometabolic risk. Calcium exhibited less straightforward results but deserves focus as well, along with antioxidant vitamin A as well as the B-complex which were mostly deficient in this experience.

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Nutritional Profile and Inflammatory Status of Hemodialysis Patients

Cited by 12 publications

References 22 publications

Serum Zinc, Plasma Ghrelin, Leptin Levels, Selected Biochemical Parameters and Nutritional Status in Malnourished Hemodialysis Patients

Serum Zinc, Plasma Ghrelin, Leptin Levels, Selected Biochemical Parameters and Nutritional Status in Malnourished Hemodialysis Patients

Nutritional evaluation of stage 5 chronic kidney disease patients on dialysis

Is Intake of Vitamin D and Calcium Important for Cardiovascular Health in Elderly Obese Patients?

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