Nutritional Problems Following Resection of the Small Intestine for Regional Ileitis

Kiefer, Everett D.; Arnold, William Thomas

doi:10.1001/jama.1950.02920110015005

Cited by 9 publications

(2 citation statements)

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“…Typical symptoms of vitamin A deficiency consist of night blindness, dry conjunctiva (xerosis) and ulceration and necrosis of the cornea (keratomalacia). Some case reports described CD patients with low plasma levels of vitamin A [35,36,37]. During acute flares of IBD, decreased serum vitamin A levels have been found [38].…”

Section: Fat-soluble Vitaminsmentioning

confidence: 99%

“…Vitamin K deficiency leads to low plasma levels of several coagulation factors in the prothrombin complex. Different case reports of CD patients with hemorrhagic problems have been reported in the literature [35,64,65]. Malabsorption is probably the most important cause of vitamin K deficiency either from extensive disease or from resection that is severe enough to interfere with bile salt absorption.…”

Section: Fat-soluble Vitaminsmentioning

confidence: 99%

See 1 more Smart Citation

Intestinal Absorption and Vitamin Levels: Is a New Focus Needed?

Vavricka

Rogler

2012

Dig Dis

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Vitamins are micronutrient chemical compounds that cannot be synthesized by an organism but are essential for human metabolism and life. They act as required intermediaries, cofactors or coenzymes in many of the reactions of normal metabolism. In addition, anti-inflammatory effects have been reported for specific vitamins. In inflammatory bowel disease (IBD), vitamin deficiency is often due to malnutrition (due to a decreased food intake) or malabsorption (due to inflamed, malfunctioning mucosa and diarrhea) which results in anemia. Vitamin B₁₂ and folic acid supplementation may be necessary in IBD patients, especially those with Crohn’s disease (CD) with either inflammation of the terminal ileum or after resection of the terminal ileum. It is also recommended during therapy with sulfasalazine as this compound inhibits the absorption of vitamin B₁₂. Patients with high or continuous inflammatory CD activity and frequent therapy with steroids have an increased risk of low bone mineral density and vitamin D deficiency. These should be monitored regularly and vitamin D should be supplemented. In a recent trial, a trend towards a reduced risk of relapses in CD patients treated with vitamin D was reported. Only limited studies and case reports exist on other vitamin deficiencies, e.g. vitamins A, B₁, B₂, niacine, B₆, C, E and K, found in IBD patients. These are summarized in this review. Regular nutritional monitoring in IBD patients is warranted and requires the special attention of treating physicians and dieticians.

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Section: Fat-soluble Vitaminsmentioning

confidence: 99%

Section: Fat-soluble Vitaminsmentioning

confidence: 99%