Nutritional myopathy in cattle associated with monensin toxicosis

Hosie, BD; Rollo, DG

doi:10.1136/vr.116.5.132

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Os sinais clínicos relacionados com distúrbios digestivos foram anorexia, diarréia e sialorréia. A anorexia foi observada em todos os bubalinos e é um dos sinais clínicos mais frequentemente descritos na intoxicação por ionóforos em bovinos (Collins & McCrea 1978, Wardrope et al 1983, Potter et al 1984, Schweitzer et al 1984, Geor & Robinson 1985, Hosie & Rollo 1985, Shlosberg et al1986, Basaraba et al 1999, Gabor & Downing 2003, Gonzalez et al 2005. A anorexia é provavelmente associada com a indução de algum tipo de informação sensorial como o sabor da monensina, ou com o mal estar resultante das alterações produzidas na fermentação ruminal (Shlosberg et al 1986).…”

Section: Discus Discus Discus Discus Discussão São São São Sãounclassified

“…O búfalo A apresentou apenas lesões macroscópicas e microscópicas na musculatura esquelética, o que também foi relatado anteriormente em bovinos (Geor & Robinson 1985, Hosie & Rollo 1985. Segundo dosagens de 40mg/kg e de 25mg/ kg de monensina sódica causaram lesão cardíaca e, em menor grau, lesão esquelética em bovinos, mas necrose de fibras musculares com presença de infiltrado macrofágico foi observada apenas a partir do 4º dia após a administração de 40mg/kg.…”

Section: Discus Discus Discus Discus Discussão São São São Sãounclassified

See 1 more Smart Citation

Intoxicação experimental por monensina em búfalos e bovinos

et al. 2007

View full text Add to dashboard Cite

Sinais clínicos e lesões característicos de intoxicação por monensina foram induzidos em búfalos dosados (1 dia) com 15, 10, 7,5 e 5mg/kg de monensina. Apenas os búfalos dosados com 2,5 (1 dia) e 1 mg/kg (7 dias) de monensina não morreram. Os sinais clínicos iniciaram cerca de 6 h após dosagem com monensina e incluíram apatia, anorexia, diarréia, sialorréia, fraqueza muscular, taquicardia, dificuldade locomotora, dispnéia, distensão da jugular, decúbito e morte. As dosagens de creatinina quinase (CK) dos búfalos aumentaram acentuadamente após dosagem com monensina. As alterações macroscópicas foram ascite, hidrotórax, hidropericárdio, cardiomegalia, hepatomegalia e áreas pálidas focais no miocárdio e nos músculos esqueléticos. Degeneração e necrose de miofibras foram os principais achados histopatológicos. Por outro lado, nenhuma evidência de doença, nem mesmo alteração nos níveis de CK, foram observados nos bovinos dosados com as mesmas dosagens de monensina, confirmando observações preliminares que esses animais são mais resistentes à monensina que os búfalos.

show abstract

Section: Discus Discus Discus Discus Discussão São São São Sãounclassified

Intoxicação experimental por monensina em búfalos e bovinos

et al. 2007

View full text Add to dashboard Cite

show abstract

“…53,54 In cases of prolonged ingestion of sublethal doses of monensin or survival of an acute monensin toxicosis, signs of congestive heart failure such as subcutaneous edema, hydrothorax, ascites, pulmonary edema, and liver congestion can be observed. 55 Histopathological evaluation reveals myocardial necrosis, vacuolar degeneration, swelling and eosinophilic staining of myocardial fibers, and vacuolation and swelling of mitochondria. 52,53 Diagnosis relies upon history of exposure, quantitation of monensin concentration of the feed, and necropsy findings.…”

Section: Feed-related Toxicantsmentioning

confidence: 99%

Retrospective study of cattle poisonings in California: recognition, diagnosis, and treatment

Varga¹,

Puschner²

2012

VMRR

View full text Add to dashboard Cite

Abstract:In this retrospective study all suspect bovine intoxications submitted to the California Animal Health and Food Safety Laboratory between January 1, 2000 and December 31, 2011 were reviewed. A total of 1199 cases were submitted, but a diagnosis of intoxication was only established in 13.5% of cases. In these cases, overexposures to minerals, metals, and poisonous plants were determined as the most commonly diagnosed poisonings in cattle in California. Nitrate/nitrite poisoning was the most commonly diagnosed plant-associated intoxication, followed by gossypol and oleander. This study details the diagnostic challenges and treatment options for the most commonly diagnosed intoxications. To ensure proper treatment and prevention of new cases, accurate diagnosis is necessary, and therefore this review provides an essential tool for the food animal practitioner. Available toxicological analyses are offered at select laboratories, which can be time consuming and expensive, yet the potential for residues in consumed animal products and implications for human health necessitate testing and consultation. Any potential exposure to a toxicant in cattle should be reviewed to determine whether a residue hazard exists. Therapy focuses on immediate removal of the toxicant from the environment and from the gastrointestinal tract. With few antidotes available, most are cost prohibitive to treat numerous affected cattle. In addition, most antidotes will require extra-label drug use and establishment of meat and milk withdrawal times.

show abstract

Incompatibility between lasalocid and chloramphenicol in broiler chicks after a long-term simultaneous administration

Brož

Frigg

1987

Veterinary Research Communications

View full text Add to dashboard Cite

Two growth experiments were conducted to evaluate in broiler chicks the compatibility between lasalocid medication in the feed (at 90 or 125 ppm) and a long-term administration of chloramphenicol either via the feed (500 ppm) or via the drinking water (500 mg/liter). The simultaneous administration of lasalocid and chloramphenicol generally caused severe growth depression, decreased feed intake and impaired feed conversion. Several chicks showed evident symptoms of intoxication, such as ataxia, leg weakness and paralysis. The development and frequency of these symptoms were dependent on the dosage of lasalocid and on the duration of the simultaneous administration. Biochemical examinations (Experiment 2) revealed in the affected chicks significant changes in several parameters, in particular a markedly increased activity of creatine kinase and GOT in the plasma. It confirmed that the observed leg weakness and paralysis were caused by myodegeneration.

show abstract

Nutritional myopathy in cattle associated with monensin toxicosis

Cited by 5 publications

References 0 publications

Intoxicação experimental por monensina em búfalos e bovinos

Intoxicação experimental por monensina em búfalos e bovinos

Retrospective study of cattle poisonings in California: recognition, diagnosis, and treatment

Incompatibility between lasalocid and chloramphenicol in broiler chicks after a long-term simultaneous administration

Contact Info

Product

Resources

About