Nutritional Modulators of Pain in the Aging Population

Smithson, Jacqueline A. J.; Kellick, Kenneth; Mergenhagen, Kari A.

doi:10.1016/b978-0-12-805186-3.00016-3

Cited by 7 publications

(6 citation statements)

References 38 publications

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“…Although some nutritional modulators are endorsed via scientific research for their ability to contribute or treat in a variety of pain and inflammation states, others (including turmeric, devil's claw, methylsulfonylmethane (MSM), Boswellia, white willow bark, and green tea) have contradictory or minimal evidence to support their use for inflammation relief. Despite the medical evidence or lack thereof, passionate consumers continue to utilize these modulators as supplements or alternatives to conventional pharmacotherapy [139].…”

Section: Discussionmentioning

confidence: 99%

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

et al. 2020

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The natural process of aging gradually causes changes in living organisms, leading to the deterioration of organs, tissues, and cells. In the case of osteoarthritis (OA), the degradation of cartilage is a result of both mechanical stress and biochemical factors. Natural products have already been evaluated for their potential role in the prevention and treatment of OA, providing a safe and effective adjunctive therapeutic approach. This review aimed to assess the therapeutic potential of natural products and their derivatives in osteoarthritis via a systematic search of literature after 2008, including in vitro, in vivo, ex vivo, and animal models, along with clinical trials and meta-analysis. Overall, 170 papers were obtained and screened. Here, we presented findings referring to the preventative and therapeutic potential of 17 natural products and 14 naturally occurring compounds, underlining, when available, the mechanisms implicated. The nature of OA calls to initially focus on the management of symptoms, and, in that context, several naturally occurring compounds have been utilized. Underlying a global need for more sustainable natural sources for treatment, the evidence supporting their chondroprotective potential is still building up. However, arriving at that kind of solution requires more clinical research, targeting the implications of long-term treatment, adverse effects, and epigenetic implications.

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Section: Discussionmentioning

confidence: 99%

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

et al. 2020

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“…Previous Gels 2023, 9, 821 2 of 15 studies have found that aqueous extracts derived from poplar buds do not cause irritation when tested on the SIRC cell line, and this suggests that these extracts could be suitable for use in the development of eye drop formulations [9]. These buds extracts are also suitable for treating rheumatoid arthritis, as salicin, gallic acid, and salicortin found in poplar buds help to reduce joint pain and swelling [10,13,14]. Moreover, poplar buds possess antiseptic, diuretic, and anti-inflammatory properties [14,15].…”

Section: Introductionmentioning

confidence: 97%

“…Currently, there is increasing interest among researchers in the plant species of the Salicaceae family, known for their capacity to accumulate phenolic acids, flavonoids, and salicin derivatives [4,5]. Phenolic compounds encountered in the buds of poplar trees have been established to possess a spectrum of bioactive properties, including anti-inflammatory, antioxidant, antimicrobial, and wound-healing attributes [6][7][8][9][10]. These properties render them valuable assets in the therapeutic management of various disorders [11,12].…”

Section: Introductionmentioning

confidence: 99%

Balsam Poplar Buds Extracts-Loaded Gels and Emulgels: Development, Biopharmaceutical Evaluation, and Biological Activity In Vitro

Jokubaite,

Pukenaite,

Marksa

et al. 2023

Gels

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Balsam poplar buds have been used for wound healing and treating irritated skin in traditional medicine. Balsam poplar buds extracts exhibit anti-inflammatory, antioxidant, and antimicrobial effects. In recent years, scientific research has begun to validate some of these traditional uses, leading to an increased interest in balsam poplar buds as a potential source of natural remedies in modern medicine. The study aims to simulate semi-solid pharmaceutical forms with balsam poplar buds extract and evaluate their quality through biopharmaceutical research. The active compounds identified in Lithuanian poplar buds were p-coumaric acid, cinnamic acid, caffeic acid, galangin, pinocembrin, pinobanksin, and salicin. In gels, pH values ranged from 5.85 ± 0.05 to 5.95 ± 0.07. The determined pH values of emulgels ranged from 5.13 ± 0.05 to 5.66 ± 0.15. After 6 h, the release of active compounds from gels and emulgels ranged from 47.40 ± 2.41% to 71.17 ± 3.54. p-coumaric acid dominates in the balsam poplar buds extracts. The pH values of the prepared sem-solid pharmaceutical forms are suitable for use on the skin. The viscosity of the formulations depends on the amount of gelling agent. All formulations showed antioxidant activity. It is relevant to conduct a more extensive study on the influence of the chosen carrier on the release of active compounds from semi-solid formulations with an extract of balsam poplar buds.

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“…are attributed to bioactive compounds such as phenolic glycoside (e.g., salicin), flavonoids (e.g., luteolin, kaempferol, and epicatechin gallate), and other phenolic compounds (e.g., catechin, syringic acid, and salicylic acid) [4][5][6]. In the case of salicin, it is absorbed after ingestion and metabolized into saligenin (in the intestine), and then into salicylic acid (in the liver), finally blocking inflammatory prostaglandins by inhibiting cyclooxygenase 1 and 2 [7,8]. Luteolin, one of the flavones, is widely contained in medicinal plants and has immunopharmacological activities [9].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Antioxidant Characterization of Extracts from Unexplored Medicinal Plants Salix schwerinii and Salix kochiana

Lee,

Song,

Son

et al. 2023

Horticulturae

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For a long time, species of the genus Salix have been widely utilized and studied as medicinal plants; however, the biological activity and phytochemical composition of Salix schwerinii (SS) and S. kochiana (SK) have not been studied at all. This study investigated the antioxidant properties of SS and SK extracts and detected phytochemical compounds in the extracts. The results showed that the antioxidant activities (IC50) of SS extract, SK extract, and ascorbic acid (reference) were as follows, respectively: 169.8, 79.8, and 71.2 μg mL−1 for ABTS cation radical scavenging and 38.4, 26.2, and 9.3 μg mL−1 for DPPH free radical scavenging. The results imply that SK has a high potential as a natural antioxidant. The phytochemical compositions of extracts (mg g−1) were analyzed as follows: SS extracts, 217.7 phenolics (1.54 catechin, 0.86 syringic acid, 0.46 luteolin, and others) and 5.06 salicin; SK extracts, 71.0 phenolics (0.54 catechin, 0.28 myricetin, 0.12 salicylic acid, and others) and 2.11 salicin. Compared to previous studies, the present findings go further to highlight that SS deserves attention as a novel source of salicin. The present study highlights the need for further studies on the aspects of medicinal functions of the extracts, bioprocess design for efficient phytochemical extraction, and applications of bioactive substances.

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Nutritional Modulators of Pain in the Aging Population

Cited by 7 publications

References 38 publications

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

Balsam Poplar Buds Extracts-Loaded Gels and Emulgels: Development, Biopharmaceutical Evaluation, and Biological Activity In Vitro

Phytochemical and Antioxidant Characterization of Extracts from Unexplored Medicinal Plants Salix schwerinii and Salix kochiana

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