Nutritional modulation of the antioxidant capacities in poultry: the case of vitamin E

Surai, Peter F.; Kochish, Ivan I.; Romanov, Michael N; Griffin, Darren K.

doi:10.3382/ps/pez072

Cited by 90 publications

(73 citation statements)

References 93 publications

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“…On the other hand, regarding the aforementioned commercially relevant stressors, there is a need for additional support for the antioxidant system in poultry. Current research is concentrated on the usage of an optimal dietary Se form [60] or increasing vitamin E supplementation [86]. There are also numerous attempts to use various phytochemicals in poultry diets, but their success is quite variable due to the low rate of the active compounds' absorption and assimilation [286].…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

et al. 2019

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Poultry in commercial settings are exposed to a range of stressors. A growing body of information clearly indicates that excess ROS/RNS production and oxidative stress are major detrimental consequences of the most common commercial stressors in poultry production. During evolution, antioxidant defence systems were developed in poultry to survive in an oxygenated atmosphere. They include a complex network of internally synthesised (e.g., antioxidant enzymes, (glutathione) GSH, (coenzyme Q) CoQ) and externally supplied (vitamin E, carotenoids, etc.) antioxidants. In fact, all antioxidants in the body work cooperatively as a team to maintain optimal redox balance in the cell/body. This balance is a key element in providing the necessary conditions for cell signalling, a vital process for regulation of the expression of various genes, stress adaptation and homeostasis maintenance in the body. Since ROS/RNS are considered to be important signalling molecules, their concentration is strictly regulated by the antioxidant defence network in conjunction with various transcription factors and vitagenes. In fact, activation of vitagenes via such transcription factors as Nrf2 leads to an additional synthesis of an array of protective molecules which can deal with increased ROS/RNS production. Therefore, it is a challenging task to develop a system of optimal antioxidant supplementation to help growing/productive birds maintain effective antioxidant defences and redox balance in the body. On the one hand, antioxidants, such as vitamin E, or minerals (e.g., Se, Mn, Cu and Zn) are a compulsory part of the commercial pre-mixes for poultry, and, in most cases, are adequate to meet the physiological requirements in these elements. On the other hand, due to the aforementioned commercially relevant stressors, there is a need for additional support for the antioxidant system in poultry. This new direction in improving antioxidant defences for poultry in stress conditions is related to an opportunity to activate a range of vitagenes (via Nrf2-related mechanisms: superoxide dismutase, SOD; heme oxygenase-1, HO-1; GSH and thioredoxin, or other mechanisms: Heat shock protein (HSP)/heat shock factor (HSP), sirtuins, etc.) to maximise internal AO protection and redox balance maintenance. Therefore, the development of vitagene-regulating nutritional supplements is on the agenda of many commercial companies worldwide.

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Section: Discussionmentioning

confidence: 99%

“…Vaccinations [70][71][72] Microbial or virus challenges [73][74][75][76][77][78] Gut dis-bacteriosis [79][80][81][82][83] Pipping and hatching [5,84,85] A growing body of evidence clearly indicates that oxidative stress is involved in most of commercially relevant stresses in poultry production (for review see [1,2,15,60,86]).…”

Section: Internal Stressorsmentioning

confidence: 99%

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

et al. 2019

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“…In addition, decreased productive and reproductive performance can cause heavy economic losses for poultry industry. Since it is almost impossible to avoid stresses in commercial poultry production, a search for nutritional means of antioxidant system modulation, including usage of increased doses of vitamin E [22], selenium [23], taurine [24] and polyphenolics [19,25], is on the agenda of many research groups world-wide. It seems likely that vitagene modulation by nutritional means (e.g., carnitine, betaine, silymarin, taurine, vitamin and minerals [7,21]) is a new strategy to prevent commercially relevant stresses and maintain high productive and reproductive performance of commercial poultry.…”

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confidence: 99%

Antioxidants in Poultry Nutrition and Reproduction: An Update

2020

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“…Similarly, Cinar et al (2010) reported that vitamin E attenuated the deleterious effects of the Cadmium-induced oxidative stress and improved the erythrocytes GPx activity. The a-Toc is one of the most essential antioxidants in the poultry nutrition and protects the cells from ROSmediated oxidative damage (Surai et al 2019). It has been reported that the oxidative stress reduces the ratio of reduced glutathione (GSH)/oxidised glutathione (GSSG), indicating higher oxidant production.…”

Section: Discussionmentioning

confidence: 99%

Hydroalcoholic extract of Withania somnifera leaf and α-tocopherol acetate in diets containing oxidised oil: effects on growth performance, immune response, and oxidative status in broiler chickens

Azimi¹,

Mirakzehi²,

Saleh³

2020

Italian Journal of Animal Science

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This study was conducted to evaluate the effects of hydroalcoholic leaf extract of Withania somnifera (WS) and a-tocopherol acetate (a-Toc) in the diets containing oxidised oil on the growth performance, immune response, and oxidative status in the broiler chickens. A 3-way factorial design (2 Â 3 Â 2) was applied consisting of the oxidised oil (0 and 2%), WS (0, 100 and 200 mg/ kg diet), and a-Toc (0 and 200 mg/kg). In total, 600 one-day-old male broilers were randomly subjected to 12 treatments with 5 replicates (10 birds/replicate). Broilers were provided with feed and water ad libitum during the 42-day experimental period. On day 42, one bird per each replicate was killed to measure the lymphoid organ weights, intestinal morphometric parameters, and MDA content in the thigh meat. Dietary oxidised oil reduced the FI, and BWG (p < .05). In contrast, dietary WS at a concentration of 200 mg/kg alleviated the negative effects of the oxidised oil on the BWG. Birds fed with the dietary oxidised oil revealed lower titres of antibody against the SRBC (p < .05). Antibody titres were significantly increased by the supplementary WS (p < .05), except for IgG, and IgM during primary and secondary responses, respectively. Dietary supplementation of WS at the concentrations of 100 or 200 mg/kg resulted in a higher CBH response after 12 h (p < .01). Birds fed with the diet supplemented with WS exhibited significantly higher spleen weight than those fed with the non-WS-supplemented diets (p < .01). Dietary oxidised oil significantly increased the MDA content in thigh meat, and inversely reduced the activity of serum antioxidant enzymes (p < .05). Birds fed with the WS-supplemented diets showed significantly lower levels of MDA content in thigh meat, and conversely higher values of serum GPx and SOD activities (p < .05). The GPx activity values were significantly higher for the birds fed with the dietary a-Toc compared to those fed with the nona-Toc-supplemented diets (p < .05). Our findings showed that the presence of WS in the broilers diets as an alternative to a-Toc could be a good approach to improve the performance, immune response, and meat oxidative stability under oxidative stress conditions. HIGHLIGHTS Dietary oxidised oil reduced the FI, and BWG, and the diets supplemented with WS leaf extract alleviated the deleterious effects of the oxidised oil on the BWG. Dietary WS revealed the immunostimulatory effects. The birds fed with the WS-supplemented diets showed a higher antibody titre against the SRBC. Dietary inclusion of WS in the broilers diets negated the negative effects of the oxidised oil by reducing the MDA content in thigh meat and increasing the activity of the antioxidant enzymes.

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Nutritional modulation of the antioxidant capacities in poultry: the case of vitamin E

Cited by 90 publications

References 93 publications

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

Antioxidants in Poultry Nutrition and Reproduction: An Update

Hydroalcoholic extract of Withania somnifera leaf and α-tocopherol acetate in diets containing oxidised oil: effects on growth performance, immune response, and oxidative status in broiler chickens

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