Nutritional manipulation to combat heat stress in poultry – A comprehensive review

Abdel-Moneim, Abdel-Moneim Eid; Shehata, Abdelrazeq M.; Khidr, R. E.; Paswan, Vinod Kumar; Ibrahim, N. S.; El-Ghoul, Abdelkawy A.; Al-Dhumri, Sami A.; Gabr, Salah A.; Mesalam, Noura M.; Elbaz, Ahmed M.; Elsayed, Mohamed A.; Wakwak, M.M.; Ebeid, Tarek A.

doi:10.1016/j.jtherbio.2021.102915

Cited by 93 publications

(38 citation statements)

References 214 publications

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“…Improving the antioxidant capacity can maintain the redox balance and normal physiological functions of intestinal epithelial cells. According to the available literature, HS has a negative influence on the antioxidant capacity and leads to oxidative stress, which can damage the cells and tissues in broilers [ 10 , 12 , 13 ]. Meanwhile, the Nrf2-mediated antioxidant signaling pathway plays a key role in mitigating oxidative stress [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, using a protective approach against HS-induced impairment of intestinal health is important for broiler production. It is currently believed that nutritional regulation is an effective strategy to protect the broilers against HS-induced intestinal injury [ 12 , 13 ]. In this regard, a variety of natural phytochemicals were used as gut health promoters in broilers, and they showed potential stress-alleviating effects because of the multiple biological activities [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Dietary Supplementation of Algae-Derived Polysaccharides on Morphology, Tight Junctions, Antioxidant Capacity and Immune Response of Duodenum in Broilers under Heat Stress

Li¹,

Zhu²,

Zhao³

et al. 2021

Animals

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To evaluate the ameliorative effect of algae-derived polysaccharide (ADP) supplementation on duodenal injury caused by heat stress (HS) in broilers, a total of 144 male yellow-feathered broilers (56-day-old) were randomly allocated into three groups: The TN group (thermoneutral zone, broilers were raised at 23.6 ± 1.8 °C); HS group (heat stress, broilers were exposed to 33.2 ± 1.5 °C 10 h/day, 8:00 a.m.–18:00 p.m., the temperature in the remaining period was consistent with the TN group); HSA group (heat-stressed broilers were fed with ADP supplemented diet at 1000 mg/kg). There were six replications in each treatment, and eight broilers in each replication. The feeding trial lasted four weeks. The results showed that dietary ADP supplementation tended to increase the villus height (p = 0.077) and villus width (p = 0.062), and decrease the apoptosis rate (p = 0.081) in the duodenum of broilers under HS. Furthermore, dietary ADP increased the relative mRNA and protein (based on immunofluorescence) expression levels of occludin and zonula occludens-1 (ZO-1) in the duodenum of broilers under HS (p < 0.05). In addition, dietary ADP enhanced the total antioxidation capacity (T-AOC) and activity of glutathione-S transferase (GST), while reducing the malondialdehyde (MDA) concentration of the duodenum in broilers under HS (p < 0.05). Moreover, dietary ADP supplementation upregulated the duodenal nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), glutathione peroxidase 1 (GPx1) and glutathione S-transferase theta 1 (GSTT1) mRNA expression levels in heat-stressed broilers (p < 0.05). Furthermore, compared with the HS group, broilers fed with an ADP supplemented diet had a higher relative mRNA expression of inhibitor kappa B alpha (IκBα) (p < 0.05) and a lower relative mRNA expression of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the duodenum (p < 0.05). In summary, dietary ADP supplementation had an ameliorative effect on HS-induced impairment of tight junctions, antioxidant capacity and the immune response of the duodenum in broilers. These beneficial effects might be related to the modulation of Nrf2 and NF-κB signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplementation of Algae-Derived Polysaccharides on Morphology, Tight Junctions, Antioxidant Capacity and Immune Response of Duodenum in Broilers under Heat Stress

Li¹,

Zhu²,

Zhao³

et al. 2021

Animals

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“…However, many studies show that drinking water uptake is only significantly increased in periods of heat stress [20,[32][33][34][35]. Heat stress occurs when the ambient temperature is above the thermal comfort zone of the birds, which for adult broilers is generally above 30 • C [36][37][38]. In commercial broiler farms, the temperature is strictly controlled through ventilation.…”

Section: Discussionmentioning

confidence: 99%

Enrofloxacin Dose Optimization for the Treatment of Colibacillosis in Broiler Chickens Using a Drinking Behaviour Pharmacokinetic Model

et al. 2021

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Enrofloxacin is frequently administered via drinking water for the treatment of colibacillosis in broiler chickens. However, the EMA/CVMP has urged to re-evaluate historically approved doses, especially for antimicrobials administered via drinking water. In response, the objectives of this study were two-fold. First, to evaluate the pharmacokinetics (PK) of enrofloxacin following IV, PO and drinking water administration. Second, to predict the efficacy of a range of doses in the drinking water for the treatment of APEC infections. For the first objective, PK parameters were estimated by fitting a one-compartmental model with a zero-order IV infusion and an oral absorption lag function to the simultaneously modelled IV and PO data. After fixing these parameter values, a drinking behaviour pharmacokinetic (DBPK) model was developed for the description and prediction of drinking water PK profiles by adding three model improvements (different diurnal and nocturnal drinking rates, inter-animal variability in water consumption and taking account of dose non-proportionality). The subsequent simulations and probability of target attainment (PTA) analysis predicted that a dose of 12.5 mg/kg/24 h is efficacious in treating colibacillosis with an MIC up to 0.125 μg/mL (ECOFF), whereas the currently registered dose (10 mg/kg/24 h) reaches a PTA of 66% at ECOFF.

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“…The development of safe and effective strategies against Cd toxicity and oxidative stress (free radical generation) is necessary; previous studies have shown that dietary supplements play an important role in reducing or preventing Cd toxicity and oxidative stress (Ebeid 2009;Al-Waeli et al 2013;Zhang et al 2017a, b;Xiong et al 2020). Free radicals damage cell phospholipid membranes and attack the vital components within the cell such as DNA, mitochondria, lysosomes, etc., which is consequently related with disorders like apoptosis, several diseases and deteriorating muscle membrane integrity (Abdel-Moneim et al 2021). Indeed, all antioxidants within the cell/body collaborate effectively together to preserve the optimum status of redox balance in the cell/body to provide protection against the damaging effects of free radicals (Eid et al 2008;Ebeid et al 2013).…”

Section: Role Of Selenium Against Cadmium Toxicitymentioning

confidence: 99%

Untitled

2022

Czech J. Anim. Sci.

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Cadmium (Cd) is a toxic heavy metal, discharged into environments naturally or anthropogenically, where industrial and agricultural revolutions have led to serious Cd pollution into the environment. Poultry feed may be contaminated by Cd due to its presence in concentrates and supplements, and also in the machinery and equipment used in the feed production and processing. After absorption in the digestive system, Cd largely accumulates in kidneys, liver, bones and other organs and causes irreversible damage to these organs. Higher doses of Cd in poultry diet reduced feed intake, body weight, bone mineral density, egg production and eggshell quality. Selenium (Se) is an essential micronutrient and important component of a variety of antioxidant enzymes, with the ability to antagonize metal toxicity including Cd. Hence, in the current review, we try to summarize recent information about the toxicological effects of Cd and provide updated information about the role of Se as an effective strategy in reducing Cd toxicity in poultry.

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Nutritional manipulation to combat heat stress in poultry – A comprehensive review

Cited by 93 publications

References 214 publications

Effects of Dietary Supplementation of Algae-Derived Polysaccharides on Morphology, Tight Junctions, Antioxidant Capacity and Immune Response of Duodenum in Broilers under Heat Stress

Effects of Dietary Supplementation of Algae-Derived Polysaccharides on Morphology, Tight Junctions, Antioxidant Capacity and Immune Response of Duodenum in Broilers under Heat Stress

Enrofloxacin Dose Optimization for the Treatment of Colibacillosis in Broiler Chickens Using a Drinking Behaviour Pharmacokinetic Model

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