Nutritional iron deficiency

Zimmermann, Michael; Hurrell, Richard F.

doi:10.1016/s0140-6736(07)61235-5

Cited by 1,097 publications

(961 citation statements)

References 127 publications

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“…Various studies have uncovered negative interactions between zinc and iron when administered at the same time (Baqui et al., 2003; Lind, Lönnerdal, & Stenlund, 2003; Penny et al., 2004). It must be stated that, under some situations, micronutrient supplementation can result in dangerous effect on the health dangerous, as reported in the case with supplementation of iron in malaria‐prone areas (Zimmermann & Hurrell, 2007). On the premise of the above‐mentioned concerns, extensive micronutrient supplementation programs become necessary, and alternative approaches, subject to prevailing local conditions, may be a better approach.…”

Section: Strategies To Tackle Micronutrient Deficiencymentioning

confidence: 99%

The suitability of chili pepper (Capsicum annuum L.) for alleviating human micronutrient dietary deficiencies: A review

Olatunji

Afolayan

2018

Food Science & Nutrition

113

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Human micronutrient dietary deficiency remains an enormous global problem and probably accounts for the cause of many chronic health conditions and diseases. Above two (2) billion individuals on the planet today have been estimated to be deficient in major minerals and vitamins, predominantly zinc, iodine, vitamin A, and iron primarily due to inadequate dietary intake. The eradication of deficiencies in micronutrient on a sustainable basis will be conceivable only when diets of vulnerable populace provide all required nutrients in adequate amounts. Among the numerous approaches toward eradicating human dietary deficiency, feeding on a wide range of foods, especially vegetables that have an array of micronutrients, is still perceived as the best sustainable solution. The universal consumption of chili peppers (Capsicum annuum), known for their high nutritional content (which includes a good range of vitamins, minerals, phytochemicals, and dietary fiber), may play a role in decreasing human micronutrient deficiencies. Significant portions of recommended daily nutrients could be supplied by the incorporation of nutrient‐rich chili pepper into human diets which could help in combating nutrient deficiencies. This present review, therefore, gives an overview of the universal occurrence of micronutrient deficiency. It also discusses approaches that have been used to tackle the situation while stressing the potentials of chili pepper as a promising vegetable which could be utilized in alleviating human micronutrient dietary deficiencies. For all available information provided, research databases (Science direct, Academic journals, PubMed, and Google Scholar) were searched independently using keyword search strategy. Titles and abstracts were examined initially, and full papers were retrieved if studies met the inclusion criteria.

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Section: Strategies To Tackle Micronutrient Deficiencymentioning

confidence: 99%

The suitability of chili pepper (Capsicum annuum L.) for alleviating human micronutrient dietary deficiencies: A review

Olatunji

Afolayan

2018

Food Science & Nutrition

113

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“…Disturbances in the supply of iron for erythropoiesis are by far the most common causes of alterations in erythrocyte ZnPP. Iron deficiency, affecting more than two billion people worldwide [5,6], decreases the delivery of iron to ferrochelatase for heme synthesis, resulting in increased formation of ZnPP [2]. In the absence of iron deficiency, disorders such as inflammation, infection and malignancy may limit the delivery of iron for erythropoiesis [7,8], increasing erythrocyte ZnPP [9].…”

Section: Introductionmentioning

confidence: 99%

Dual‐wavelength excitation for fluorescence‐based quantification of zinc protoporphyrin IX and protoporphyrin IX in whole blood

Hennig

Gruber

Vogeser

et al. 2013

Journal of Biophotonics

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Journal of BIOPHOTONICSQuantification of erythrocyte zinc protoporphyrin IX (ZnPP) and protoporphyrin IX (PPIX), individually or jointly, is useful for the diagnostic evaluation of iron deficiency, iron-restricted erythropoiesis, lead exposure, and porphyrias. A method for simultaneous quantification of ZnPP and PPIX in unwashed blood samples is described, using dual-wavelength excitation to effectively eliminate background fluorescence from other blood constituents. In blood samples from 35 subjects, the results of the dualwavelength excitation method and a reference high performance liquid chromatography (HPLC) assay were closely correlated both for ZnPP (r s ¼ 0.943, p < 0.0001; range 37-689 mmol ZnPP/mol heme, 84-1238 nmol/L) and for PPIX (r s ¼ 0.959, p < 0.0001; range 42-4212 mmol PPIX/mol heme, 93-5394 nmol/L). In addition, for ZnPP, the proposed method is compared with conventional single-wavelength excitation and with commercial front-face fluorimetry of washed erythrocytes and whole blood. We hypothesize that dual-wavelength excitation fluorimetry will provide a new approach to the suppression of background fluorescence in blood and tissue measurements of ZnPP and PPIX.

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“…At the same time, the prevalence of anaemia in China is decreasing but remaining high (15?2 % in 2002) (1) . Diet plays an important role in both diseases (2,3) . While Fe deficiency may lead to anaemia (3) , findings from many countries show that high Fe intake, especially haem Fe intake (4) , and high body Fe stores increase the risk of diabetes (5)(6)(7) .…”

mentioning

confidence: 99%

“…Diet plays an important role in both diseases (2,3) . While Fe deficiency may lead to anaemia (3) , findings from many countries show that high Fe intake, especially haem Fe intake (4) , and high body Fe stores increase the risk of diabetes (5)(6)(7) . Possible mechanisms for Fe increasing the risk of diabetes may include oxidative stress, inflammation, free fatty acid oxidation, insulin extraction and secretion (6) .…”

mentioning

confidence: 99%

Iron intake and body iron stores, anaemia and risk of hyperglycaemia among Chinese adults: the prospective Jiangsu Nutrition Study (JIN)

Shi

Zhou

Bao

et al. 2009

Public Health Nutr.

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Objective: Fe supplementation has been used to prevent anaemia in China; however, high Fe intake and body Fe stores may increase diabetes risk. The present study aimed to prospectively examine the association between Fe intake/ stores and hyperglycaemia, and to assess the joint effects on anaemia. Design: We followed 1056 healthy adults aged 20 years and older from 2002 to 2007. Body Fe stores were measured. Dietary data were collected using a 3 d food record and FFQ. Hyperglycaemia was defined as fasting plasma glucose .5?6 mmol/l. Results: Of the participants, 28?8 % were anaemic at baseline. During the 5 years of follow-up, we documented 125 incident cases of hyperglycaemia, among them twenty-three were diabetic. Haem Fe intake was positively associated with the risk of hyperglycaemia in men and women: the OR (95 % CI) across increasing quartiles of haem Fe intake was 1?00 (referent), 1?49 (0?74, 3?01), 2?16 (1?06, 4?42) and 3?48 (1?71, 7?11), respectively (P for trend ,0?001). Comparing the fourth quartile of serum ferritin with the others, the age-and gender-adjusted OR (95 % CI) was 1?54 (1?01, 2?34), P for trend 5 0?043. The association between total Fe intake and the risk of hyperglycaemia was significant in men (P for trend 5 0?002). Anaemia added additional risk of hyperglycaemia on haem Fe intake. Comparing extreme quartiles of haem Fe intake, the OR (95 % CI) was 5?67 (1?43, 22?49) and 3?44 (1?51, 7?85) for hyperglycaemia among anaemic and non-anaemic participants (P for trend 5 0?008 and 0?010, respectively). Conclusions: The present cohort study suggests that high haem Fe intake, anaemia and high ferritin are associated with an increased risk of hyperglycaemia in Chinese men and women. There was a joint effect between anaemia and haem Fe intake on the risk of hyperglycaemia.

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Nutritional iron deficiency

Cited by 1,097 publications

References 127 publications

The suitability of chili pepper (Capsicum annuum L.) for alleviating human micronutrient dietary deficiencies: A review

The suitability of chili pepper (Capsicum annuum L.) for alleviating human micronutrient dietary deficiencies: A review

Dual‐wavelength excitation for fluorescence‐based quantification of zinc protoporphyrin IX and protoporphyrin IX in whole blood

Iron intake and body iron stores, anaemia and risk of hyperglycaemia among Chinese adults: the prospective Jiangsu Nutrition Study (JIN)

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