Nutritional Genetics and Energy Metabolism in Human Obesity

Conn, Carole A.; Vaughan, Roger A.; Garver, William S.

doi:10.1007/s13668-013-0046-2

Cited by 7 publications

(4 citation statements)

References 88 publications

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“…Obesity has been recognized as a heritable disorder in recent decades [ 138 ]. It has become increasingly clear that sedentary lifestyles and an increased availability of inexpensive calorie-dense foods have played a pivotal role in creating an obesogenic environment, which has contributed to the obesity epidemic [ 139 – 141 ].…”

Section: Molecular Connectivity Of Oxidative Stress-induced Diseasmentioning

confidence: 99%

Nutrients and Oxidative Stress: Friend or Foe?

Tan

Norhaizan

Liew

2018

Oxidative Medicine and Cellular Longevity

236

181

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There are different types of nutritionally mediated oxidative stress sources that trigger inflammation. Much information indicates that high intakes of macronutrients can promote oxidative stress and subsequently contribute to inflammation via nuclear factor-kappa B- (NF-κB-) mediated cell signaling pathways. Dietary carbohydrates, animal-based proteins, and fats are important to highlight here because they may contribute to the long-term consequences of nutritionally mediated inflammation. Oxidative stress is a central player of metabolic ailments associated with high-carbohydrate and animal-based protein diets and excessive fat consumption. Obesity has become an epidemic and represents the major risk factor for several chronic diseases, including diabetes, cardiovascular disease (CVD), and cancer. However, the molecular mechanisms of nutritionally mediated oxidative stress are complex and poorly understood. Therefore, this review aimed to explore how dietary choices exacerbate or dampen the oxidative stress and inflammation. We also discussed the implications of oxidative stress in the adipocyte and glucose metabolism and obesity-associated noncommunicable diseases (NCDs). Taken together, a better understanding of the role of oxidative stress in obesity and the development of obesity-related NCDs would provide a useful approach. This is because oxidative stress can be mediated by both extrinsic and intrinsic factors, hence providing a plausible means for the prevention of metabolic disorders.

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Section: Molecular Connectivity Of Oxidative Stress-induced Diseasmentioning

confidence: 99%

Nutrients and Oxidative Stress: Friend or Foe?

Tan

Norhaizan

Liew

2018

Oxidative Medicine and Cellular Longevity

236

181

View full text Add to dashboard Cite

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“…MTIF3 promotes the formation of the initiation complex on the mitochondrial 55S ribosome, which is essential for energy balance in the mitochondria (73) . This gene has also been identified as an obesity susceptibility gene due to its relationship with BMI (74,75) . Papandonatos and colleagues showed that the G allele of the MTIF3 rs1885988 was associated with greater weight loss following lifestyle intervention over 4 years of follow-up (76) .…”

Section: Nutrient Metabolism-related Genes and Their Association Withmentioning

confidence: 99%

The impact of genetic polymorphisms on weight regain after successful weight loss

2020

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Abstract Obesity is associated with an increased risk of various diseases and mortality. Although nearly 50 % of adults have been reported trying to lose weight, the prevalence of obesity has increased. One factor that hinders weight loss-induced decrease in obesity prevalence is weight regain. Although behavioural, psychological and physiological factors associated with weight regain have been reviewed, the information regarding the relationship between weight regain and genetics has not been previously summarised. In this paper, we comprehensively review the association between genetic polymorphisms and weight regain in adults and children with obesity after weight loss. Based on this information, identification of genetic polymorphism in patients who undergo weight loss intervention might be used to estimate their risks of weight regain. Additionally, the genetic-based risk estimation may be used as a guide for physicians and dietitians to provide each of their patients with the most appropriate strategies for weight loss and weight maintenance.

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“…One of the reasons for this difference may be differences in gene expression. About 127 genes have been identified as metabolism-related genes and genome-wide association studies (GWAS) have validated approximately 50 obesity susceptibility genes [10][11][12], and genome-wide association studies (GWAS) revealed the robust association of the gene with adiposity, body weight, BMI or class of obesity, and percent body fat [13].…”

Section: Introductionmentioning

confidence: 99%

The Effect of ω3 Fatty Acids Supplementation on Levels of PPARγ and UCP2 Genes Expression, Serum Level of UCP2 Protein, Metabolic Status, and Appetite in Elite male Athletes: Protocol for a Randomized Control Trial

Moradi

Alivand

Khajebishak

et al. 2021

International Journal of Surgery Protocols

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Some genetic factors may influence body composition, such as PPARγ and UCP2. PPARγ plays an important role in body fat distribution. The objective of the present study is to determine the effects of omega3 fatty acids on the gene expression of PPARγ and UCP2, levels of blood lipid profile, fat mass, and fat-free mass, and appetite.Elite male athlete volunteers of up to 36 subjects were invited to participate in this RCT. Following a public announcement, volunteers were recruited from gyms, teams, and sports medicine boards in Tabriz, Iran. Gene's expression of PPARγ and UCP2, serum levels of blood lipid profile, fat mass, and fat-free mass was collected. Data collection time points include baseline in addition to 3 weeks follow up. The study was approved by the Ethics Committee of the Tabriz University Medical of Sciences (IR.TBZMED.

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Nutritional Genetics and Energy Metabolism in Human Obesity

Cited by 7 publications

References 88 publications

Nutrients and Oxidative Stress: Friend or Foe?

Nutrients and Oxidative Stress: Friend or Foe?

The impact of genetic polymorphisms on weight regain after successful weight loss

The Effect of ω3 Fatty Acids Supplementation on Levels of PPARγ and UCP2 Genes Expression, Serum Level of UCP2 Protein, Metabolic Status, and Appetite in Elite male Athletes: Protocol for a Randomized Control Trial

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