Nutritional Factors Affecting the Activity of Liver Nicotinamide Methyltransferase and Urinary Excretion of TV<sup>1</sup>-Methylnicotinamide in Rats

Shibata, Katsumi

doi:10.1080/00021369.1986.10867603

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“…The resulting homogenate was used as an enzyme source. The methods used to measure the enzyme activities involved in the Nam catabolic pathway, Nam methyltransferase (NMTase) (S-adenosyl-l-methionine: nicotinamide N-methyltransferase, EC 2.1.1.1), 20 2-Py-forming MNA oxidase (aldehyde: oxygen oxidoreductase, EC 1.2.3.1), 21 and 4-Py-forming MNA oxidase (EC number not determined), 21 have been described previously.…”

Section: Introductionmentioning

confidence: 99%

Conversion Percentage of Tryptophan to Nicotinamide is Higher in Rice Protein Diet than in Wheat Protein Diet in Rats

Shibata

Fukuwatari

Kawamura

2015

Int J�Tryptophan�Res

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We reported previously that the pellagragenic property of corn protein is not only low l-tryptophan concentration but also the lower conversion percentage of l-tryptophan to nicotinamide; the amino acid composition greatly affected the conversion percentage. The amino acid value of wheat protein is lower than that of rice protein. In the present study, we compare the conversion percentages of l-tryptophan to nicotinamide between wheat protein and rice protein diets in growing rats. The body weight gain for 28 days in rats fed with a 10% amino acid mixture diet with wheat protein was lower than that of rats fed with a 10% amino acid diet with rice protein (68.1 ± 1.6 g vs 108.4 ± 1.9 g; P < 0.05). The conversion percentage of l-tryptophan to nicotinamide was also lower for the wheat protein diet compared with the rice protein diet (1.44 ± 0.036% vs 2.84 ± 0.19%; P < 0.05). The addition of limiting amino acids (l-isoleucine, l-lysine, l-tryptophan, l-methionine, l-threonine) to the wheat protein diet improved growth and the conversion percentage. In conclusion, our result supports the thinking that the composition of amino acids affects the conversion ratio of l-tryptophan to nicotinamide.

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Section: Introductionmentioning

confidence: 99%

Conversion Percentage of Tryptophan to Nicotinamide is Higher in Rice Protein Diet than in Wheat Protein Diet in Rats

Shibata

Fukuwatari

Kawamura

2015

Int J�Tryptophan�Res

Self Cite

View full text Add to dashboard Cite

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Nutritional Factors Affecting the Activity of Liver Nicotinamide Methyltransferase and Urinary Excretion of TV¹-Methylnicotinamide in Rats

Cited by 1 publication

References 4 publications

Conversion Percentage of Tryptophan to Nicotinamide is Higher in Rice Protein Diet than in Wheat Protein Diet in Rats

Conversion Percentage of Tryptophan to Nicotinamide is Higher in Rice Protein Diet than in Wheat Protein Diet in Rats

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Nutritional Factors Affecting the Activity of Liver Nicotinamide Methyltransferase and Urinary Excretion of TV1-Methylnicotinamide in Rats

Cited by 1 publication

References 4 publications

Conversion Percentage of Tryptophan to Nicotinamide is Higher in Rice Protein Diet than in Wheat Protein Diet in Rats

Conversion Percentage of Tryptophan to Nicotinamide is Higher in Rice Protein Diet than in Wheat Protein Diet in Rats

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Nutritional Factors Affecting the Activity of Liver Nicotinamide Methyltransferase and Urinary Excretion of TV¹-Methylnicotinamide in Rats