Nutritional effects on oocyte and embryo development in mammals: implications for reproductive efficiency and environmental sustainability

Ashworth, Cheryl; Toma, Luiza; Hunter, M. G.

doi:10.1098/rstb.2009.0184

Cited by 174 publications

(127 citation statements)

References 66 publications

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“…Both animal and human studies have shown that the preconception environment may alter oocyte maturation 69 with maternal obesity affecting the metabolism of the developing ova and early offspring growth 70,71 . Because mitochondrial DNA is only passed on through the maternal line, oocyte mitochondrial DNA may provide a further sex-specific intergenerational mechanism.…”

Section: Mechanisms Involving Parental Gametesmentioning

confidence: 99%

Adolescence and the next generation

Patton

Olsson

Skirbekk

et al. 2018

Nature

281

228

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Adolescent growth and social development shape the early development of offspring from preconception through to the post-partum period through distinct processes in males and females. At a time of great change in the forces shaping adolescence, including the timing of parenthood, investments in today’s adolescents, the largest cohort in human history, will yield great dividends for future generations.

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Section: Mechanisms Involving Parental Gametesmentioning

confidence: 99%

Adolescence and the next generation

Patton

Olsson

Skirbekk

et al. 2018

Nature

281

228

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“…Vinsky et al (2006) and Patterson et al (2011) observed similar losses in sows submitted to feed restriction during lactation. Several authors suggest that the nutritional and metabolic changes in lactating sows may have deleterious effects on dam biology, with negative impacts on follicle development, and consequently on embryo development and on the number of piglets born in the next litter (Foxcroft et al, 2007;Ashworth et al, 2009;Quesnel, 2009;Schenkel et al, 2010;Hoving et al, 2011). According to Foxcroft et al (2009), the mechanisms affecting fertility may involve hormonal changes, as well as epigenetic changes and/or changes in the expression of genes related to embryo development.…”

Section: Discussionmentioning

confidence: 99%

Impact of feed restriction on the performance of highly prolific lactating sows and its effect on the subsequent lactation

Bettio

Maiorka

Barrilli

et al. 2016

Animal

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A total of 50 mixed parity sows of a high-prolificacy genetic line were used to evaluate the impact of feed restriction during lactation on their production and reproductive performance and their performance in the subsequent lactation. From day 7 of lactation, sows were distributed according to a completely randomized experimental design into two treatments. In treatment 1, sows were fed 8.0 kg feed/day (control) and in treatment 2, sows were fed 4.0 kg/day. The same suckling pressure was maintained until weaning on day 28 of lactation. Average minimum and maximum temperatures measured during the experimental period were 32.1°C and 16.5°C, respectively. Control sows presented significantly higher feed intake (P<0.001) compared with the restricted sows (6.43 v. 4.14 kg/day, respectively). Treatments influenced BW and backfat thickness losses (P<0.001). Control sows lost less BW than the restricted-fed sows (7.8 v. 28.2 kg). Restricted-fed sows lost more backfat thickness than those in the control group (3.97 v. 2.07 mm; P<0.01). Restricted-fed sows tended (P<0.10) to be lighter at weaning compared with the control sows (211 v. 227 kg). The composition of BW loss was influenced by the treatments (P<0.001), as the restricted-fed sows lost more body protein, lipids and energy compared with the control sows (3.90 v. 0.98 kg, 11.78 v. 4.83 kg and 584 v. 224 MJ, respectively). Litter weight gain was greater (P<0.05) in control sows than in restricted-fed sows (2.70 v. 2.43 kg/day). Daily milk production was 19% higher (P<0.01) in the control sows compared with the restricted-fed sows (8.33 v. 6.99 kg/day). However, restricted-fed sows presented a higher (P<0.05) lactation efficiency than the sows of the control group (82.30% v. 72.93%). No differences were detected (P>0.10) in weaning-to-estrus interval and averaged 4.3 days. No effect of the treatment (P>0.10) was observed on any of the studied performance traits in the subsequent lactation, except for litter size at birth that tended (15.2 v. 14.1; P<0.10) to be lower for the restricted sows. In conclusion, the present study demonstrated that feed restriction during lactation leads to intense catabolism of the body tissues of sows, negatively affecting their milk production, and the litter weight gain and possibly number of piglets born in the next litter. On the other hand, restricted-fed sows are more efficient, producing more milk per amount of feed intake.

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“…One well-known example of this "environmental buffering" is the heat-shock response. Although the influence of diet on reproductive capability has been well demonstrated in Drosophila melanogaster, Caenorhabditis elegans, and mammals (Ashworth et al 2009;Ables et al 2012;Hubbard et al, 2013), to our knowledge, mechanisms by which gametogenesis efficiency is maintained under suboptimal environments have not been explored. Our study suggests the hypothesis that differential partitioning of cell fate within a yeast community provides environmental buffering-here termed the DPEB hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Cell Differentiation and Spatial Organization in Yeast Colonies: Role of Cell-Wall Integrity Pathway

Piccirillo¹,

Morales²,

White³

et al. 2015

Genetics

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Many microbial communities contain organized patterns of cell types, yet relatively little is known about the mechanism or function of this organization. In colonies of the budding yeast Saccharomyces cerevisiae, sporulation occurs in a highly organized pattern, with a top layer of sporulating cells sharply separated from an underlying layer of nonsporulating cells. A mutant screen identified the Mpk1 and Bck1 kinases of the cell-wall integrity (CWI) pathway as specifically required for sporulation in colonies. The CWI pathway was induced as colonies matured, and a target of this pathway, the Rlm1 transcription factor, was activated specifically in the nonsporulating cell layer, here termed feeder cells. Rlm1 stimulates permeabilization of feeder cells and promotes sporulation in an overlying cell layer through a cell-nonautonomous mechanism. The relative fraction of the colony apportioned to feeder cells depends on nutrient environment, potentially buffering sexual reproduction against suboptimal environments.KEYWORDS cell-wall integrity; cell permeability; cell-cell signaling; Saccharomyces cerevisiae; sporulation A S embryos develop, cells of different fates organize into patterns [reviewed in Kicheva et al. (2012) and Perrimon et al. (2012)] . Intriguingly, even unicellular microbial species form communities in which different cell types are organized into patterns [reviewed in Kaiser et al. (2010), Honigberg (2011, and Loomis (2014)]. For example, colonies of the budding yeast Saccharomyces cerevisiae form an upper layer of larger cells (U cells) overlying a layer of smaller cells (L cells). U and L cells differ in their metabolism, gene expression, and resistance to stress, and U and L layers are separated by a strikingly sharp boundary Vachova et al. 2013). Patterns are also observed in yeast biofilms, where cells closest to the plastic surface grow as ovoid cells, whereas cells further from the surface differentiate into hyphae for Candida species [reviewed in Finkel and Mitchell (2011)] or pseudohyphae and eventually asci for S. cerevisiae (White et al. 2011).Sporulation also occurs in patterns within yeast colonies. Specifically, a narrow horizontal layer of sporulated cells forms through the center of the colony early during colony development. As colonies continue to mature, this layer progressively expands upward to include the top of the colony; this wave is driven by progressive alkalization and activation of the Rim101 signaling pathway . In contrast, cells at the bottom of the colony, i.e., directly contacting the agar substrate, also sporulate at early stages of colony development, but this narrow cell layer does not expand as the colony matures . The same colony sporulation pattern is observed in a range of laboratory yeasts as well as in S. cerevisiae and S. paradoxus isolated from the wild. Indeed, in these wild yeasts, the same colony sporulation pattern forms on a range of fermentable and nonfermentable carbon sources .The mechanism of sporulation patterning and its function remai...

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Nutritional effects on oocyte and embryo development in mammals: implications for reproductive efficiency and environmental sustainability

Cited by 174 publications

References 66 publications

Adolescence and the next generation

Adolescence and the next generation

Impact of feed restriction on the performance of highly prolific lactating sows and its effect on the subsequent lactation

Cell Differentiation and Spatial Organization in Yeast Colonies: Role of Cell-Wall Integrity Pathway

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