Nutritional Deficiencies and Excesses

Hurley, Lucille S.

doi:10.1007/978-1-4684-2850-6_7

Cited by 21 publications

(11 citation statements)

References 274 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is always difficult to study the timing of exposure due to the maternal bias. Nevertheless, OR values in the different strata (Table 4 and 5), although not statistically significant (at 5% level), suggest both dose-effect and time-effect relationships, which are consistent with the experimental literature (7).…”

Section: Discussionsupporting

confidence: 79%

“…The Morgagni hernia was very rare in our data (1.5 per 100,000 livebirths). As far as we know, the only reference to a relationship between vitamin A and diaphragmatic hernia is for hypovitaminosis A in animals (7). Nevertheless, according to the studies on retinoids (8,20) there seems to be an optimum concentration of retinoids, below and above which, alterations in cellular differentiation can be produced.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiological aspects of prenatal exposure to high doses of vitamin a in Spain

Martínez‐Frías

Salvador

1990

Eur J Epidemiol

View full text Add to dashboard Cite

Reports of the human teratogenicity of retinoids have raised concern about the potential human teratogenicity of high doses of vitamin A. Nevertheless, there are few human case reports of excess intake of vitamin A during pregnancy and defective outcomes. No epidemiological studies have been carried out on this subject. Here we present the results of an epidemiological study of prenatal exposure to high doses of vitamin A in Spain, using data from the Spanish hospital-based, case-control registry. Although it is difficult to reach conclusions with such a very low exposure level (1.3 per 1,000 livebirths), our results suggest that a teratogenic effect might exist for exposures to high doses of vitamin A (OR = 0.5, p = 0.15 for less than 40,000 IU and OR = 2.7, p = 0.06 for 40,000 IU or more). As we might expect, this effect also seems to be related to the organogenetic status (OR = 5.4, p = 0.1 for 1st-2nd month, OR = 1.8, p = 0.4 for 3rd onwards) at the time of exposure.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Epidemiological aspects of prenatal exposure to high doses of vitamin a in Spain

Martínez‐Frías

Salvador

1990

Eur J Epidemiol

View full text Add to dashboard Cite

show abstract

“…In experimental animals, prenatal zine defieieney is teratogenie. Congenital malformations in zine-defieient embryos may result from impaired synthesis of nucleie acids (Hurley, 1976(Hurley, , 1977. Reeently, Sandstead et al (1977) reported that zine deficieney during the last trimester of pregnaney in rhesus monkeys adversely…”

Section: Trace Mineralsmentioning

confidence: 97%

Association of Fetal Growth with Maternal Nutrition

Metcoff

1978

Principles and Prenatal Growth

View full text Add to dashboard Cite

“…However, many controver sies arise around the possible disorders caused by low-level exposure (not resulting in detectable thermal effects) to MW fields [2,7,17,18,26,29]. There exists a general agree ment that these disorders may involve func tional disintegrations (due to specific action of MWs or to nonspecific stress reactions of the exposed dams), which are manifested only postnatally [13,21], with decreased fetal and neonatal mass being one of the most con sistent effects of the intrauterine exposure [2,3], Therefore, until now, MWs have not gained much interest as a teratogenic agent as neither malformations, increased number of resorptions, nor disorders in development of preimplantation embryos were documented after exposure to nonthermal MW fields [3,5,16,17,22], However, the consistently noted lowering of fetal mass is considered by some authors [15] as an important index of neonatal condition, representing a more se vere demonstration of the teratogenic poten tial of MWs than would only the delayed growth of the fetus [3],…”

mentioning

confidence: 99%

Microwave Radiation Enhances Teratogenic Effect of Cytosine Arabinoside in Mice

Marcickiewicz¹,

B²,

Niemiec³

et al. 1986

Neonatology

View full text Add to dashboard Cite

Impregnated Swiss mice were irradiated 2 h daily on days 1–18 of gestation in nonthermal (1 or 10 mW/cm²) or thermogenic (40 mW/cm²) 2,450-MHz microwave (MW) fields. On the 19th day of pregnancy all dams were killed to check the number of resorptions. Living fetuses were isolated, weighed and checked for the presence of macroscopically visible malformations of skeleton and cleft palate (CP) and/or lip (CLP). Some of the pregnant mice in each group were injected intraperitoneally on the 9th day of gestation with 10 mg/kg of cytosine arabinoside (ara-C), a well-known teratogen resulting under the above conditions in the appearance of about 15% (42 of 354) of resorbed implantation points and the development of CP or CLP in about 30% (96 of 312) of fetuses. Exposure to nonthermal MW fields during pregnancy did not lead to resorptions or detectable malformations; however, the body mass of 19-day fetuses was significantly lower than in sham-irradiated controls. MW hyperthermia (40 mW/cm²) applied during pregnancy led to an increased number of resorptions -about 25% (37 of 157) compared to 2% (6 of 306) in controls. Significant enhancement of the teratogenic potency of ara-C was observed after combined exposure to both ara-C and MWs during pregnancy. In dams treated with ara-C alone about 20% (62 of 358) resorptions and about 30% (91 of 296) fetuses with CL or CLP were found; additional exposure in MW fields (10 mW/cm²), not resulting per se in resorptions or detectable malformations, increased the numbers to 45% (213 of 448) of resorptions and to 70% (167 of 235) fetuses with CL or CLP. In view of results obtained, we conclude that the relatively weak embryotoxic effects of MWs may be revealed and markedly enhanced after combination of radiation with other teratogenic factors.

show abstract

Nutritional Deficiencies and Excesses

Cited by 21 publications

References 274 publications

Epidemiological aspects of prenatal exposure to high doses of vitamin a in Spain

Epidemiological aspects of prenatal exposure to high doses of vitamin a in Spain

Association of Fetal Growth with Maternal Nutrition

Microwave Radiation Enhances Teratogenic Effect of Cytosine Arabinoside in Mice

Contact Info

Product

Resources

About