Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review

Diwan, Bhawna; Sharma, Rohit

doi:10.1007/s10068-022-01114-y

Cited by 15 publications

(5 citation statements)

References 236 publications

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“…Nutrition and a healthy lifestyle are intimately linked and can greatly impact cellular senescence. Nutritional elements can influence cellular senescence, with evidence for VitD from both in vitro and in vivo research [ 39 ]. In preclinical models, interventions targeting senescent cells have been shown to delay, prevent, or alleviate tissue damage and multiple disorders.…”

Section: The Hallmarks Of Agingmentioning

confidence: 99%

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Ruggiero,

Tafaro,

Cianferotti

et al. 2024

Nutrients

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Aging is the result of several complex and multifactorial processes, where several agents contribute to an increased intrinsic vulnerability and susceptibility to age-related diseases. The hallmarks of aging are a set of biological mechanisms that are finely regulated and strictly interconnected, initiating or contributing to biological changes and anticipating several age-related diseases. The complex network of cellular and intercellular connections between the hallmarks might represent a possible target for the research of agents with pleiotropic effects. Vitamin D (VitD) is known to have a positive impact not only on muscle and bone health but also on several extra-skeletal districts, due to the widespread presence of Vitamin D Receptors (VDRs). VitD and VDR could be molecules potentially targeting the hallmarks of the aging network. To date, evidence about the potential effects of VitD on the hallmarks of aging is scarce in humans and mainly based on preclinical models. Although underpowered and heterogeneous, in-human studies seem to confirm the modulatory effect of VitD on some hallmarks of aging and diseases. However, more investigations are needed to clarify the pleiotropic effects of VitD and its impact on the hallmark of aging, hopefully highlighting the courses for translational applications and potential clinical conclusions.

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Section: The Hallmarks Of Agingmentioning

confidence: 99%

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Ruggiero,

Tafaro,

Cianferotti

et al. 2024

Nutrients

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“…Aging is a complex biological process, which is closely related to cell function [200]. Over the past few decades, a growing body of research has found that cellular senescence is a key driver of many age-related diseases.…”

Section: Relationship Between Cellular Senescence and Agingmentioning

confidence: 99%

Molecular mechanisms of aging and anti-aging strategies

Li,

Tian,

Luo

et al. 2024

Cell Commun Signal

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Aging is a complex and multifaceted process involving a variety of interrelated molecular mechanisms and cellular systems. Phenotypically, the biological aging process is accompanied by a gradual loss of cellular function and the systemic deterioration of multiple tissues, resulting in susceptibility to aging-related diseases. Emerging evidence suggests that aging is closely associated with telomere attrition, DNA damage, mitochondrial dysfunction, loss of nicotinamide adenine dinucleotide levels, impaired macro-autophagy, stem cell exhaustion, inflammation, loss of protein balance, deregulated nutrient sensing, altered intercellular communication, and dysbiosis. These age-related changes may be alleviated by intervention strategies, such as calorie restriction, improved sleep quality, enhanced physical activity, and targeted longevity genes. In this review, we summarise the key historical progress in the exploration of important causes of aging and anti-aging strategies in recent decades, which provides a basis for further understanding of the reversibility of aging phenotypes, the application prospect of synthetic biotechnology in anti-aging therapy is also prospected.

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“…One comprehensive review showed the anti-senescence mechanism of nutritional elements such as carbohydrates, proteins, fatty acids, vitamins, minerals, polyphenols, and probiotics. [ 43 ]…”

Section: Senescence Under Control By Different Lifestylesmentioning

confidence: 99%

The ABC-associated immunosenescence and lifestyle interventions in autoimmune disease

Ruan

Wang

Yang

et al. 2022

Rheumatology and Immunology Research

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Aging-associated immune changes, termed immunosenescence, occur with impaired robust immune responses. This immune response is closely related to a greater risk of development of autoimmune disease (AID), which results in increased levels of autoantibodies and increased morbidity and mortality. In addition, lifestyle-related risk factors play a pivotal role in AID, which may be probable via senescence-related immune cell subsets. Age-associated B cell (ABC) subsets have been observed in those who have rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and multiple sclerosis (MS). Here, this review aims to highlight the mechanisms of ABCs with lifestyle interventions in AID, especially how immunosenescence affects the pathogenesis of AID and the future of aging-associated lifestyle interventions in immunosenescence of AID.

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Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review

Cited by 15 publications

References 236 publications

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Molecular mechanisms of aging and anti-aging strategies

The ABC-associated immunosenescence and lifestyle interventions in autoimmune disease

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