Nutritional Characterization, Antioxidant, and Lipid-Lowering Effects of Yellow Mombin (Spondias mombin) Supplemented to Rats Fed a High-Fat Diet

Abstract

The aim of this study was to evaluate the effects of supplementing yellow mombin (YM) on the oxidative, somatic, and lipid parameters in rats fed a high-fat diet. A total of 24 adult Wistar rats were randomized into three groups: normal-fat diet (NF), high-fat diet (HF), and high-fat diet with YM supplementation (HFYM). Diets were administered for four weeks, and YM (400 mg/kg) was supplemented via gavage in the last two weeks of the experiment. After the four-week period, the somatic, serum biochemical, and liver oxidative parameters were evaluated. YM has a high antioxidant activity and significant amounts of phenolic compounds, carotenoids, vitamin C, dietary fibre, and minerals. The HFYM group had the lowest body weight (18.75%), body mass index (17.74%), and adiposity (31.63%) compared with the HF group. YM supplementation reduced low-density lipoprotein by 43.05% and increased high-density lipoprotein by 25.73%, but did not improve the triglyceride levels in the serum. YM treatment improved glucose tolerance and lipid peroxidation, and also enhanced the antioxidant capacity, superoxide dismutase, and glutathione peroxidase activities in the liver. These results indicate the lipid-lowering property and potential antioxidant activity of YM against liver oxidative damage caused by a high-fat diet intake, which may be associated with the bioactive compounds present in this fruit.

Phytopharmacological Activities of Spondias mombinLinn: A Review

“…24,[51][52][53] Several researches have been done on the antioxidant efficacy of S. mombin. 24,54,55 A study evaluated the protective actions of the leaf and stem methanol extracts of S. mombin in rat model of carbon tetrachloride (CCl4)-induced hepatotoxicity. Pretreatment with 1000 mg/kg of the extracts markedly increased glutathione, catalase and superoxide dismutase levels.…”

Spondias tuberosa and Spondias mombin: Nutritional Composition, Bioactive Compounds, Biological Activity and Technological Applications

“…According to Table 1, carbohydrates are the major nutrient present in S. mombin fruit [18,48,49,56]. Concerning the organic acids, Lucena et al [24] identified acetic acid (3.34 ± 0.21 mg/g dw) and malic acid (6.00 ± 0.12 mg/g dw) in the S. mombin fruit.…”

“…Lucena et al [24] evaluate the effects of supplementing S. mombin (pulp and peel) on the oxidative, somatic, and lipid parameters of rats fed a high-fat diet. A portion of 400 mg/kg of body weight was supplemented via gavage for 14 days.…”

“…Moreover, several studies have documented health benefits associated with the fruit and their components. Antioxidant and antibacterial actions, acetylcholinesterase inhibition, and cancer chemopreventive activity have already been reported [20][21][22][23][24].…”

Functional Foods with Modulating Action on Metabolic Risk Factors

“…Xu et al [8] showed that administration of hydroxyl-α-sanshool, a long-chain unsaturated fatty acid amide extracted from Zanthoxylumbungeanum Maxim fruit (0.8 mg/kg for 28 days), improved the richness and diversity of gut microbiota, decreased the Firmicutes/Bacteroidetes ratio, and reduced glycosylated hemoglobin and diabetic dyslipidemia in streptozotocin-induced insulin resistance in rats. Lucena et al [9], investigating the functional properties of yellow mombin (Spondias mombin), showed that yellow mombin supplementation (400 mg/kg for two weeks) decreased dyslipidemia and oxidative stress in rats fed a high-fat diet. Cheng et al [10] developed an herbal formula consisting of three ingredients (bainiku-ekisu, black garlic, and Mesona procumbens Hemsl), named Mei-Gin formula.…”