Nutritional Challenges in Metabolic Syndrome

Hoyas, Irene; León‐Sanz, Miguel

doi:10.3390/jcm8091301

Cited by 77 publications

(63 citation statements)

References 73 publications

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“…A recent review showed that moderate weight loss (between 5 and 10% of one’s initial body weight) resulted in a significant reduction in glucose, triglycerides, and total cholesterol and improved insulin sensitivity by between 30 and 60%, which are effects greater than those seen with insulin-sensitizing drugs [ 66 ]. In the CD group, a significant reduction in fasting plasma glucose, insulin resistance that was assessed using the HOMA-IR index, and total cholesterol and LDL-C was observed, while the level of HbA1c remained almost the same.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of an Energy-Restricted Anti-Inflammatory Diet for the Management of Obesity in Younger Adults

et al. 2020

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There is growing evidence of the dietary impact on obesity-induced low-grade chronic inflammation and the associated chronic non-communicable diseases modification. We determined changes in body composition and cardiometabolic and inflammatory status of participants with obesity after 24 weeks of a dietary intervention based on an energy-reduced anti-inflammatory diet and examined the relationship of these changes with changes in the inflammatory potential of the diet. The anthropometric and body composition parameters of 81 participants (average age of 43 years, 74 women) were assessed. Metabolic status was determined using the glycemic and lipid statuses, and the cardiometabolic index and inflammatory status were determined using the concentration of high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α). The inflammatory potential of the diet was assessed using the Dietary Inflammatory Index (DII®). Intervention with an anti-inflammatory diet resulted in a significant reduction in body weight and visceral adipose tissue and caused improvements in the participants’ cardiometabolic and inflammatory statuses. The anti-inflammatory diet was shown to be effective regarding obesity management. The study data could advance current scientific knowledge in the field of inflammation and diet, provide guidelines for obesity management, and find its application in routine clinical practice.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of an Energy-Restricted Anti-Inflammatory Diet for the Management of Obesity in Younger Adults

et al. 2020

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“…The increased intake of carbohydrates with a high glycemic Index (GI) is known to directly induce insulin resistance and contribute to the development of type 2 diabetes in MetS patients. On the other hand, diets with a low GI, high in fiber, increase the feeling of satiety and reduce insulin resistance and the risk of type 2 diabetes [29]. It is also suggested that people's health may be influenced by the local environment.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between the IFNG (rs2430561) Polymorphism and Metabolic Syndrome in Perimenopausal Women

et al. 2020

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Background and Objectives: Metabolic syndrome (MetS) is a multiple risk factor for atherosclerosis, cardiovascular disease, type 2 diabetes and strokes. One-third of middle-age women are at risk of MetS, which predisposes them to type 2 diabetes and cardiovascular disease. Changes in the regulation of anti-inflammatory cytokines―which play an important role in pathologic processes―may contribute to inflammatory disorders. Cytokine polymorphisms are known to have an impact on gene expression. The purpose of this study was to search for the relationship between the IFNG polymorphisms and the levels of proinflammatory cytokines. Materials and Methods: This study, conducted in West Pomeranian Voivodeship, Poland, involved 416 women. Of these women, 33.6% of them had primary education, 44.8% lived in cities with a population of over 100,000, and 82.7% were married. Of the participants, 28.4% met the criteria for MetS. The study involved: interview performed to collect sociodemographic and medical data, anthropometric measurements, as well as venous blood collection for biochemical analysis, genetic testing and the measurement of inflammatory markers. Results: The link between the IFNG (rs2430561) polymorphism and serum PIC (proinflammatory cytokines) levels was tested with regard to MetS. In the MetS+ subgroup, the T/T and A/T genotypes of the IFNG gene were accompanied by higher IL-6 levels than in the MetS− subgroup. Conclusion: Our study has not confirmed a direct link between the IFNG polymorphisms and the levels of inflammatory biomarkers. Nevertheless, the T/T and A/T genotypes of the IFNG gene may predispose to elevated IL-6 levels.

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“…Long-term adherence to a healthy lifestyle is the key of lifestyle management for patients with metabolic syndrome. Several dietary patterns have been proved to ameliorate insulin resistance and MetS including Mediterranean-style, dietary approaches to stop hypertension (DASH), low-carbohydrate, and low-fat diets [ 37 ]. Neurohormonal activation is one of the mechanisms involved in MetS.…”

Section: Management Of the Metabolic Syndrome In Preventing Heart Faimentioning

confidence: 99%

Metabolic syndrome and heart failure: mechanism and management

Laksono

Prawara

2021

Medicine and Pharmacy Reports

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Heart failure (HF) and metabolic syndrome (MetS) are syndromes that affect a large proportion of the world population. MetS is known to be one of the risk factors of HF, and it can also act as comorbidity in HF. This review aims to further discuss the mechanism of MetS in causing HF, the management of MetS in order to prevent HF, and the management of MetS in HF patients. Visceral adiposity is the primary trigger of MetS which is followed by chronic inflammation, insulin resistance, and neurohormonal activation. All the mechanisms causing MetS play also an important role in the progression of HF. The MetS approach can be achieved by managing its components according to the current guidelines and careful management of MetS should be done in patients with HF. MetS is closely related to the progression of HF so that comprehensive management which involves a multidisciplinary team is necessary for managing patients with metabolic syndrome and heart failure.

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Nutritional Challenges in Metabolic Syndrome

Cited by 77 publications

References 73 publications

The Efficacy of an Energy-Restricted Anti-Inflammatory Diet for the Management of Obesity in Younger Adults

The Efficacy of an Energy-Restricted Anti-Inflammatory Diet for the Management of Obesity in Younger Adults

The Relationship between the IFNG (rs2430561) Polymorphism and Metabolic Syndrome in Perimenopausal Women

Metabolic syndrome and heart failure: mechanism and management

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