“…Subsequent studies found that individuals with hypercholesterolemia exhibit a greater susceptibility to AD [2,3,4]. Further, abnormalities of cholesterol levels in AD patients have been noted both in serum and in the brain [5,6,7,8,9,10]. Some studies implicated high-density lipoprotein (HDL) as the central agent in AD development, with AD patients having lower HDL levels and the extent of decrease being associated with AD severity [8].…”