Nutritional Biomarkers as Predictors of Dysphonia Severity in Patients with Ischemic Stroke

Kim, Ji Min; Yoo, Seung Don; Park, Eo Jin

doi:10.3390/nu15030652

Cited by 3 publications

(3 citation statements)

References 64 publications

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“…Together with malnutrition, dysphonia is a major problem in patients who have experienced an ischemic stroke. The study conducted by Kim and colleagues [2] found that serum levels of transferrin, albumin, and prealbumin were significantly correlated with the dysphonia severity index and maximum phonation time levels. In a multiple regression analysis, prealbumin and transferrin were found to be significant predictors of the dysphonia severity index, whereas prealbumin alone was a significant predictor of the maximum phonation time.…”

Section: Nutrition In Post-stroke Subjects During Rehabilitation Mari...mentioning

confidence: 97%

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Nutrition in Post-Stroke Subjects during Rehabilitation

Siotto

Aprile

2023

Nutrients

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Section: Nutrition In Post-stroke Subjects During Rehabilitation Mari...mentioning

confidence: 97%

“…Two of three studies analyzed albumin, prealbumin, and transferrin as nutritional biomarkers in post-stroke patients. Park et al studied these nutritional biomarkers in association with heart rate variability [1], while Kim et al examined them as predictors of dysphonia severity [2].…”

Section: Nutrition In Post-stroke Subjects During Rehabilitation Mari...mentioning

confidence: 99%

Nutrition in Post-Stroke Subjects during Rehabilitation

Siotto

Aprile

2023

Nutrients

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“…On the other hand, prealbumin (PA), synthesized in the liver, plays a crucial role in blood transport [ 8 ]. With a shorter half-life compared to albumin, PA provides a rapid reflection of the patient's nutritional status [ 9 ]. Low PA levels indicate malnutrition and compromised liver function.…”

Section: Introductionmentioning

confidence: 99%

Predictive nomograms based on gamma-glutamyl transpeptidase to prealbumin ratio for prognosis of hepatocellular carcinoma patients without microvascular invasion

Ma,

Xie,

Jin

et al. 2024

BMC Cancer

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Background Hepatocellular carcinoma (HCC) presents a significant threat to individuals and healthcare systems due to its high recurrence rate. Accurate prognostic models are essential for improving patient outcomes. Gamma-glutamyl transpeptidase (GGT) and prealbumin (PA) are biomarkers closely related to HCC. This study aimed to investigate the predictive value of the GGT to PA ratio (GPR) and to construct prognostic nomograms for HCC patients without microvascular invasion. Methods We retrospectively analyzed data from 355 HCC patients who underwent radical hepatectomy at Shengjing Hospital of China Medical University between December 2012 and January 2021. Patients were randomly assigned to a training cohort (n = 267) and a validation cohort (n = 88). The linearity of GPR was assessed using restricted cubic spline (RCS) analysis, and the optimal cut-off value was determined by X-tile. Kaplan–Meier survival curves and log-rank tests were used to investigate the associations between GPR and both progression-free survival (PFS) and overall survival (OS). Cox multivariate regression analysis identified independent risk factors, enabling the construction of nomograms. Time-dependent receiver operating characteristic (ROC) and calibration curves were used to evaluate the accuracy of the nomograms. Decision curve analysis (DCA) assessed the predictive value of the models. Results Patients were categorized into GPR-low and GPR-high groups based on a GPR value of 333.33. Significant differences in PFS and OS were observed between the two groups (both P < 0.001). Cox multivariate analysis identified GPR as an independent risk factor for both PFS (OR = 1.80, 95% CI: 1.24–2.60, P = 0.002) and OS (OR = 1.87, 95% CI: 1.07–3.26, P = 0.029). The nomograms demonstrated good predictive performance, with C-index values of 0.69 for PFS and 0.76 for OS. Time-dependent ROC curves and calibration curves revealed the accuracy of the models in both the training and validation cohorts, with DCA results indicating notable clinical value. Conclusions GPR emerged as an independent risk factor for both OS and PFS in HCC patients without microvascular invasion. The nomograms based on GPR demonstrated relatively robust predictive efficiency for prognosis.

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Gender differences in Nutritional Status, Food consumption and Oxidative Stress in Post-Stroke patients during Rehabilitation

SIOTTO,

Cocco,

Guerrini

et al. 2023

Preprint

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Objectives This study aimed to clarify the gender differences in nutritional status, food consumption and oxidative stress and in post-stroke patients during rehabilitation treatment. Design A longitudinal observational study. Methods Patients with first stroke were sequentially enrolled, evaluated at admission (T0), and again after a 6-week rehabilitation program (T1). The rehabilitation regimen included traditional and robotic physical therapy. Functional independence in Activity of Daily Living (ADL) was evaluated with modified Barthel Index assesment (mBI T0 and mBI T1) and calculating its change after rehabilitation (∆BI= mBIT1- mBI T0). Patients were screened for malnutrition at admission, following the GLIM criteria, by the Mini Nutritional Assessment Short-form (MNA-SF®) and the assessment of the nutritional status during the study was performed by means of: i) anthropometric measurements ii) the Geriatric Nutritional Risk assessment (GNRI), and iii) daily estimation of food consumption (plate waste). An Analysis of blood parameters at T0 and at T1 was performed including: albumin, glucose, lipidic panel, calcium, magnesium and iron. Systemic Oxidative stress status was evaluated at T0 and at T1 measuring: hydroperoxides (dROMs), total antioxidants (BAP), thiols (-SHp) and calculating the antioxidant capacity (OSI index). Results We finally included 87 patients in this study (42 women, 45 men mean age 69 ± 12 years). The sample was homogeneous and the whole group was at highly risk of malnutrition at admission with 44 subjects clearly malnurished (score lower than 7). Women wasted 23% of total plate consumed respect to 17% wasted from men. Hydroperoxides levels were very high in the whole groupat T0 and T1, but men after rehabilitation had lower values of dROMs, while women did not. Men reached higher value of mBI T1 respect to women (67.1 ± 21.9 vs 55.3 ±26.1; p = 0.032), moreover only 36% of women ameliorated their mBI of at least ten point, respect to 64% of men. MNA-SF® correlated with mBI T0, mBI T1 and ∆BI, but in women this correlation was higher [mBI T0 (rho = 0.506 p<0.001); with mBI T1 (rho = 0.527; p<0.001); with ∆BI (rho = 0.394; p = 0.001)], suggesting a relationship between their nutritional status at admission and their performance in functional recovery. Conclusions. Among subacute post stroke patients hospitalized for rehabilitation treatment, women appeared to have lower rehabilitation outcome, to waste more food and to have higher oxidative stress even after six-week of hospitalization. So, especially in consideration of the advanced age, women should be carefully monitored forn nutritional status during hospitalization for rehabilitation; future studies should clarify if a better nutrition, which includes the right dose of antioxidants, can improve their recovery after stroke.

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Nutritional Biomarkers as Predictors of Dysphonia Severity in Patients with Ischemic Stroke

Cited by 3 publications

References 64 publications

Nutrition in Post-Stroke Subjects during Rehabilitation

Nutrition in Post-Stroke Subjects during Rehabilitation

Predictive nomograms based on gamma-glutamyl transpeptidase to prealbumin ratio for prognosis of hepatocellular carcinoma patients without microvascular invasion

Gender differences in Nutritional Status, Food consumption and Oxidative Stress in Post-Stroke patients during Rehabilitation

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