Nutritional assessment of somatolactin function in gilthead sea bream (Sparus aurata): concurrent changes in somatotropic axis and pancreatic hormones

Celis, Silvia Vega-Rubı́n de; Rojas, Pablo A.; Gómez‐Requeni, Pedro; Albalat, Amaya; Gutiérrez, Joaquím; Médale, Françoise; Kaushik, Sadasivam; Navarro, Isabel; Pérez‐Sánchez, Jaume

doi:10.1016/j.cbpb.2004.06.007

Cited by 51 publications

(26 citation statements)

References 41 publications

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“…Combined data on plasma GH and SL levels have not been included in this article, although previous studies clearly proved in gilthead sea bream a specific seasonal pattern for each GH/PRL family member . Furthermore, opposite trends for circulating GH and SL have been reported with advancing age and changes in nutritional condition, arising from shifts in ration size, dietary composition, and secretagog effects of arginine (Company et al 2001, Vega-Rubín de Celis et al 2004b.…”

Section: Discussionmentioning

confidence: 99%

Co-expression of IGFs and GH receptors (GHRs) in gilthead sea bream (Sparus aurata L.): sequence analysis of the GHR-flanking region

Saera-Vila¹,

Calduch-Giner²,

Pérez‐Sánchez

2007

Journal of Endocrinology

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The tissue-specific expression of IGFs and GH receptors (GHRs) was analyzed in gilthead sea bream (Sparus aurata L.) as an attempt to understand the functional partitioning of duplicated GHRs on the regulation of fish growth by season and aging. Gene transcripts were measured in liver, muscle, and adipose tissue by means of quantitative real-time PCR assays. In juvenile fish, concurrent increases in circulating levels of GH and IGF-I and hepatic mRNA levels of IGF-I and GHR-I were evidenced with the summer growth spurt. Conversely, muscle and adipose tissue expression of GHR-I and IGF-II were significantly upregulated by overwintering. The aging decrease of growth rates was accompanied by a reduced activity of the liver GH/IGF axis, and parallel increases in muscle IGF expression would be dictated at the local tissue level by the enhanced expression of GHR-I. Extra-hepatic expression of IGFs and GHR-II did not correlate seasonally in juvenile fish, and nonsignificant effects of aging were found on the summer expression of GHR-II in any analyzed tissue. One transcription start site was identified by RLM-RACE in GHR-I and GHR-II. Sequence analyses indicated that both genes have TATA-less promoters containing consensus initiator sequences and downstream promoter elements surrounding the transcription start site. Conserved CCAAT-boxes and GC-rich regions were retrieved in the GHR-I promoter, whereas stress-and redoxsequence elements (cAMP-responsive element-binding protein, activator proteins; AP-1, and AP-4) were characteristic features of GHR-II. All this supports the functional partitioning of fish GHRs regardless of fish species differences.

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Section: Discussionmentioning

confidence: 99%

Co-expression of IGFs and GH receptors (GHRs) in gilthead sea bream (Sparus aurata L.): sequence analysis of the GHR-flanking region

Saera-Vila¹,

Calduch-Giner²,

Pérez‐Sánchez

2007

Journal of Endocrinology

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“…Prolactin (PRL), growth hormone (GH) and somatolactin (SL) belong to an identical hormone family because of their structural similarities but have different functions related to diverse physiological processes (Manzon, 2002;Pérez-Sánchez and Le Bail, 1999;Vega-Rubin de Celis et al, 2004). PRL is essential for acclimation to hyposmotic environments and is also related to processes such as reproduction, stress and metabolism (Laiz-Carrión et al, 2009;Mancera and McCormick, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, GH regulates growth and intermediary metabolism and has osmoregulatory effects in some species (Mancera and McCormick, 2007;Sakamoto and McCormick, 2006). SL is related to different physiological processes, including stress response, reproduction, acid-base regulation, growth and reproduction (Fukamachi and Meyer, 2007;Vega-Rubin de Celis et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

The influence of stocking density and food deprivation in silver catfish (Rhamdia quelen): A metabolic and endocrine approach

et al. 2015

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The influence of stocking density and food deprivation on energy metabolism, stress processes and the pituitary endocrine system of silver catfish (Rhamdia quelen) was investigated after a period of 14 days, in which plasmatic and hepatic parameters and the mRNA expression of prolactin (PRL), growth hormone (GH) and somatolactin (SL) were assessed. The fish were subjected to four experimental conditions: (1) fed under high stocking density (32 kg/m 3 , HSD); (2) fed under mean stocking density (16 kg/m 3 , MSD); (3) fed under low stocking density (8 kg/m 3 , LSD); and (4) food-deprived under low stocking density (8 kg/m 3 , LSD-FD). After 14 days, plasma and liver samples were obtained to analyze the metabolite levels and enzymatic activities related to metabolism, and pituitary glands were obtained to analyze hormone expression (PRL, GH and SL). Liver weight and the hepato-somatic index (HSI) revealed that specimens maintained at HSD and/or MSD had higher hepatic stores, which were observed in the triglyceride and glycogen levels in this tissue, than animals submitted to the LSD and LSD-FD groups. Triglyceride levels in the plasma and liver revealed the consumption of fatty acid reserves in the fasting group. Enzymatic activities, such as glutamate dehydrogenase (GDH), phosphorylase (GPase), pyruvate kinase (PK), aspartate transaminase (AST) and glycerol-3-phosphate dehydrogenase (G3PDH), indicated an increase in gluconeogenic pathways in the HSD group and an increase in glycolitic metabolism in the LSD groups. The expression of PRL was not affected by stocking density and/or food deprivation and GH decreased with increased density and increased in fasting conditions. A negative effect of density and fasting was observed on the expression of SL. Overall, the data suggested that juvenile silver catfish reared at stocking densities of 16 to 32 kg/m 3 were better maintained than those maintained at the lowest density.

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“…Prolactin and growth hormone, together with somatolactin belong to the same family of adenohypophyseal hormones and are released from the pituitary to exert endocrine control of a very diverse array of physiological processes (Zhu et al, 2007). In fish, somatolactin has been shown to be required for normal control of pigmentation (Fukamachi et al, 2004(Fukamachi et al, , 2009) and may also play roles in osmoregulation (Kaneko, 1996), stress (Rand-Weaver et al, 1993, acid-base regulation (Kakizawa et al, 1996) and metabolism (Vega-Rubin de Celis et al, 2004). Prolactin is mainly implicated in osmoregulation, having a role in fresh to salt water adapatation (Manzon, 2002;Sakamoto and McCormick, 2006), but various other stressors have also been shown to increase plasma prolactin levels in salmonids (Avella et al, 1991;Auperin et al, 1995;Weber and Grau, 1999).…”

Section: Discussionmentioning

confidence: 96%

The antidepressant drug Carbamazepine induces differential transcriptome expression in the brain of Atlantic salmon, Salmo salar

et al. 2014

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Nutritional assessment of somatolactin function in gilthead sea bream (Sparus aurata): concurrent changes in somatotropic axis and pancreatic hormones

Cited by 51 publications

References 41 publications

Co-expression of IGFs and GH receptors (GHRs) in gilthead sea bream (Sparus aurata L.): sequence analysis of the GHR-flanking region

Co-expression of IGFs and GH receptors (GHRs) in gilthead sea bream (Sparus aurata L.): sequence analysis of the GHR-flanking region

The influence of stocking density and food deprivation in silver catfish (Rhamdia quelen): A metabolic and endocrine approach

The antidepressant drug Carbamazepine induces differential transcriptome expression in the brain of Atlantic salmon, Salmo salar

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