Nutritional Aspects of Alcoholic Liver Disease

Leevy, Carroll M.; Moroianu, Şerban A.

doi:10.1016/j.cld.2004.11.003

Cited by 75 publications

(74 citation statements)

References 45 publications

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“…Avoidance of alcohol intake is required to eliminate progressive liver disease in alcoholics. This is best achieved by using educational and social programs to convince patients and their caretakers of the great necessity to eliminate alcohol intake (Leevy and Moroianu, 2005).…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Mota¹,

Guedes²,

Areias³

et al. 2010

Alcohol

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Alcohol abuse is an important public health problem. In Portugal with a population of 10 millions of inhabitants, there are around 10% of alcoholics or excessive alcohol drinkers and 1% of chronically infected patients with hepatitis B virus (HBV). To examine the characteristics of patients with higher levels of alcohol consumption and to investigate the association between alcohol consumption and liver damage a total of 298 chronically infected individuals, with HBV genotyped and submitted to liver biopsy, were classified with Child's grading and separated by habits of alcohol intake, less and greater than 20 g/day. No significant differences were observed about genotype but genotypes A and D were predominant in both of them. A higher percentage of males (P ! .001) were observed in the group with alcohol intake above 20 g/day, as well a lower proportion of patients with HBeAg negativity (P #.035). In this group, biochemistry parameters, such as alanine aminotransferase (P 5 .006), aspartate aminotransferase (P 5 .001), gamma-glutamyl transferase (P ! .001) were elevated in a significantly higher proportion than in the other group. The analysis of hematological parameters showed significantly lower values of platelets (P 5 .042) and mean corpuscular volume (P ! .001) and significantly higher values of prothrombin time (P ! .001) in the group with higher levels of alcohol consumption. The characteristics of biopsy (P ! .001) and ChildePhug's classification (P 5 .002) revealed more severe results in this group. Logistic regression showed a positive association between liver damage and alcohol intake, increasing with age. In female patients, a strong positive association between alcohol intake and liver damage was also found (odds ratio: 9.379; 95% confidence interval: 0.859e468.422; P 5 .037); however, the most severe cases were only observed in women older than 45 years. In patients with HBV infection, alcohol is associated with a more severe liver disease. No evidence was found concerning association with HBV genotype. Ó

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Section: Discussionmentioning

confidence: 99%

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Mota¹,

Guedes²,

Areias³

et al. 2010

Alcohol

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show abstract

“…The enzymes involved in the conversion of retinol to its active form are the same as those used to metabolize ethanol, suggesting a possible disruption in Vitamin A metabolism with chronic alcoholics. Deficiency can result in eye disorders, such as night blindness, and impaired immune function [48]. Excess Vitamin A can also have harmful consequences for chronic alcoholics.…”

Section: Alcoholism and Micronutrient Deficiencymentioning

confidence: 99%

“…Thiamin deficiency is the most common vitamin deficiency seen in chronic alcoholics, and may be the most important cause of tissue damage [48]. It occurs as a result of decreased intake, reduced absorption, and malutilization [50] and affects the cardiovascular (wet beriberi) and nervous (dry beriberi and Wernicke-Korsakoff syndrome) systems.…”

Section: Alcoholism and Micronutrient Deficiencymentioning

confidence: 99%

“…Levels of Vitamin B12 are often normal in chronic alcoholics until development of pancreatic insufficiency and/or liver disease due to the large body stores of the vitamin [48].…”

Section: Alcoholism and Micronutrient Deficiencymentioning

confidence: 99%

“…Vitamin B6 deficiency can be partly responsible for neurologic, hematologic, and dermatologic disorders in alcoholics. Alcoholics may be deficient in Vitamin B6 but not exhibit hematological or abnormal liver function [48].…”

Section: Alcoholism and Micronutrient Deficiencymentioning

confidence: 99%

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