Nutritional Approaches to Treating Sarcopenia

Effect of whey protein supplementation after resistance exercise on the muscle mass and physical function of healthy older women: A randomized controlled trial

“…Future exercise and nutritional supplementation studies will need to include measurements of vitamin D status. There is current evidence of a positive effect of a supplementation of approximately 2500–2800 mg of leucine in increasing the rate of muscle protein synthesis in healthy older individuals . In the present study, we used a high dose of leucine supplementation of 2975 mg; however, a recent study reported an increase in muscle protein synthesis in healthy older women at a smaller amount of leucine supplementation .…”

“…There is current evidence of a positive effect of a supplementation of approximately 2500-2800 mg of leucine in increasing the rate of muscle protein synthesis in healthy older individuals. [4][5][6][7][8] In the present study, we used a high dose of leucine supplementation of 2975 mg; however, a recent study reported an increase in muscle protein synthesis in healthy older women at a smaller amount of leucine supplementation. 30 In the present study, the EX + PRO group and EX group that should have a greater amount of exercise than the PRO group had greater bodyweight gain, even though the energy intakes were identical.…”

“…The postprandial muscle protein synthesis response is modulated by the type and amount of total protein of the supplement . There is current evidence of a positive effect of a supplementation of approximately 20–25 g of whey protein or daily total protein intake of at least of 1.2 g/kg bodyweight/day during resistance exercise training in older individuals . Leucine contained in whey protein has been reported to stimulate muscle protein synthesis by activating the mammalian target of the rapamycin signaling pathway .…”

“…3 There is current evidence of a positive effect of a supplementation of approximately 20-25 g of whey protein or daily total protein intake of at least of 1.2 g/kg bodyweight/day during resistance exercise training in older individuals. [4][5][6][7][8] Leucine contained in whey protein has been reported to stimulate muscle protein synthesis by activating the mammalian target of the rapamycin signaling pathway. [4][5][6][7][8] As muscle protein synthesis peaks after exercise, followed by a gradual time-dependent decrease, providing whey protein after exercise in a supplement form that is quickly digested and absorbed could be important in optimizing muscle protein accumulation.…”

“…[4][5][6][7][8] Leucine contained in whey protein has been reported to stimulate muscle protein synthesis by activating the mammalian target of the rapamycin signaling pathway. [4][5][6][7][8] As muscle protein synthesis peaks after exercise, followed by a gradual time-dependent decrease, providing whey protein after exercise in a supplement form that is quickly digested and absorbed could be important in optimizing muscle protein accumulation. 9,10 However, previous studies have not identified a benefit of protein supplementation after resistance exercise in enhancing muscle mass among older individuals.…”